Possibility of Local Allergic Rhinitis in Japan

Abstract

Background The concept of local allergic rhinitis (LAR) has been advocated recently. Allergic rhinitis in Japan is characterized by house dust mites (HDMs) and Japanese cedar pollen (JCP). To investigate LAR in Japan, total IgE and antigen-specific IgE (sIgE) were measured in inferior turbinate mucosa and their relationships with skin test (ST) and nasal allergen provocation test (NAPT) and as well as serum IgE levels were examined. Methods Subjects were 50 rhinosinusitis patients for surgery. ST was performed and serum total IgE and sIgE levels were measured preoperatively. Patients with class-0 serum anti-HDM or anti-JCP sIgE levels were subjected to NAPT with HDM or JCP, respectively, or both. In all patients, inferior turbinate mucosa was weighed and mashed, and total IgE and sIgE levels were then measured as local mucosal date per gram and per milligram. Because there is no clinical consensus how to evaluate nasal sIgE yet, both positive NAPT and detectable sIgE in obtained nasal mucosa were adopted as the diagnostic criteria of LAR in order to strictly elucidate the possibility of presence of LAR in Japan. Results JCP LAR was definitely diagnosed in 2 of 14 patients (14.3%) and HDM LAR in 5 of 21 (23.8%) in cases with rhinosinusitis symptoms in the absence of positive ST nor serum sIgE. Conclusion The present results positively support LAR by HDM or JCP being present in Japan.

Nasal IgE in subjects with allergic and non-allergic rhinitis

“…15 Demographical differences might be attributable as a study group in China found a prevalence of LAR in only 7.7% of patients in a cohort of 195 individuals whilst Ishida et al recently published data suggesting a prevalence of LAR in 2 of 14 patients (14.3%) and HDM LAR in 5 of 21 (23.8%) in a study of 50 highly selected Japanese patients suffering from chronic rhinosinusitis. 16,17 Contrary to these conclusions others found no prevalence of nasal IgE in patients with nonallergic rhinitis. 18 Such discrepant data was obtained in selected populations of subjects suffering from rhinitis.…”

Factors associated with generalized pustular psoriasis progression among patients with psoriasis vulgaris in Japan: Results from a claims database study

“…However, allergic rhinitis and asthma are heterogeneous disorders with multiple immunological phenotypes, including a Th2/Th17 reaction 29,31,33–35 ; therefore, clinical linkage with psoriasis may be possible via the Th17 pathway 29 . It should also be noted that allergic rhinitis is a common disease among the Japanese population, with a prevalence of approximately 40% 36 . The low risk of allergic rhinoconjunctivitis, asthma, and obesity‐associated patients with GPP requires further research.…”

“…29 It should also be noted that allergic rhinitis is a common disease among the Japanese population, with a prevalence of approximately 40%. 36 The low risk of allergic rhinoconjunctivitis, asthma, and obesity-associated patients with GPP requires further research.…”

Editorial

“…In addition, allergic rhinitis may also contribute to lingual tonsil hypertrophy as suggested by Coban et al 14 Yet, establishing a diagnosis of allergic rhinitis may be elusive. This is underscored by Ishida et al 15 who identified that many patients undergoing surgery for CRS were identified to have elevated nasal antibodies to house dust mites and Japanese cedar pollen despite negative blood and skin allergy tests. The difficulty of identifying the underlying pathogenesis of CRS can also be perplexing.…”

“…This is underscored by Ishida et al. 15 who identified that many patients undergoing surgery for CRS were identified to have elevated nasal antibodies to house dust mites and Japanese cedar pollen despite negative blood and skin allergy tests. The difficulty of identifying the underlying pathogenesis of CRS can also be perplexing.…”