Possibilities of using thoracoscopy under local anesthesia and proteolytic enzymes in the removal of coagulated hemothorax

Зайцев, Д. А.; Мовчан, К. Н.; Lyshenko, Viktor V.; Slobodkina, Anna S.; Kochetkov, A. V.; Русакевич, К. И.

doi:10.21638/11701/spbu11.2018.304

Cited by 2 publications

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“…Залишається актуальною проблема раннього виявлення і профілактики ускладнень гострої деструктивної пневмонії, що супроводжуються піофібринотораксом [1,3,4,9]. Це пов'язано з несвоєчасною діагностикою ускладнень запальних захворювань бронхолегеневої системи, труднощами діагностики на початкових етапах формування ускладнень у вигляді піофібринотораксу, тривалим і не завжди адекватним амбулаторним лікуванням [2,5,6,8].…”

Section: вступunclassified

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Êë³í³÷íà ïåä³àòð³ÿ / Clinical Pediatrics

ВступЗалишається актуальною проблема раннього виявлення і профілактики ускладнень гострої деструктивної пневмонії, що супроводжуються піофібринотораксом [1,3,4,9]. Це пов'язано з несвоєчасною діагностикою ускладнень запальних захворювань бронхолегеневої системи, труднощами діагностики на початкових етапах формування ускладнень у вигляді піофібринотораксу, тривалим і не завжди адекватним амбулаторним лікуванням [2,5,6,8].Добре відомо, що в діагностиці плеврального випоту основне значення має комплексна діагностика: рентгенологічне й ультразвукове дослідження (УЗД), мультиспіральна комп'ютерна томографія [5].

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The importance of ultrasound in the diagnosis of pleura complications of acute destructive pneumonia in children

Dihtiar¹,

Halahan²,

Lukianenko³

2022

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Background. The problem of timely diagnosis of complications of acute destructive pneumonia accompanied by pyofibrothorax remains relevant. The study was aimed to investigate the features of ultrasound diagnosis (ultrasound) of the condition of the visceral and parietal pleural lamina in acute destructive pneumonia in children at different stages of the disease. Materials and methods. In the departments of purulent surgery and pulmonology of the Regional Children’s Hospital of Dnipro for the period of 5 years, there were observed about 475 children aged from 1 to 17 years with pneumonia, purulent-destructive changes in the lungs and pleura. For analysis and further study, we choose a group of 50 patients of different age groups, who underwent ultrasound in real time without prior preparation of patients. The condition of the parietal and visceral pleural lamina at the different stages of diagnosis and treatment was studied. Results. A group of patients aged from 4 to 10 years was performed an ultrasound of the pleural cavities in real time without prior preparation on the paraspinal, scapular, axillary, midclavicular, and thoracic lines when admitted to the hospital and on the first day of treatment. Ultrasound was used to determine the structure and volume of free fluid as well as the condition of the parietal and visceral pleural lamina, their thickness, and other features. The use of ultrasound allowed diagnosing the early manifestations of pyofibrothorax and determining the condition of the parietal and visceral pleural lamina in the children with destructive pneumonia. Conclusion. Further improvement of the algorithm of ultrasound diagnosis of acute destructive pneumonia in children with pyofibrothorax will reduce radiation exposure to a child’s body, increase the efficiency of the development and improvement of treatment methods at the stages of pyofibrotorax, reduce the duration of inpatient treatment.

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Section: вступunclassified

“…

Êë³í³÷íà ïåä³àòð³ÿ / Clinical Pediatrics

…”

unclassified

The importance of ultrasound in the diagnosis of pleura complications of acute destructive pneumonia in children

Dihtiar¹,

Halahan²,

Lukianenko³

2022

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The Possibilities of Using Proteolytic Enzymes in Lymphotropic Therapy

G.V.,

M.V.,

D.E.

2024

Vestnik "Biomedicina i sociologiya"

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Proteolytic enzymes have a variety of pharmacological effects, which determines their important role and place in clinical medicine. The aim of this study was to confirm the lymphostimulating effect of terrilytin, an integral part of the drug terridecase, and to study its effect on the pharmacokinetic parameters of cefotaxime. Materials and methods of research. Assessment of the rate of lymphatic drainage in the mesentery of mice by the time of removal of lymphotropic dye from it; determination of the concentration of the antibiotic cephalosporin antibiotic of the third generation cefotaxime in rabbit blood plasma during the day, blood plasma, intestinal tissues and liver of white mongrel mice after 1.5 and 24 hours of experiment by high-performance liquid chromatography. Results. It has been confirmed that terrilytin has a lymphostimulating effect. It has been established that this proteolytic enzyme has the properties of an endolymphatic conductor. Its preliminary administration increases the concentration of cefotaxime in the blood plasma of rabbits and mice compared with monovision of the antibiotic at all time points of the study, up to a day, and increases its content in the intestinal tissue of mice, both 1.5 hours and 24 hours after injection of drugs. Terrilytin does not affect the level of cefotaxime in the liver tissue of mice, but reduces the ratio of its concentrations "liver tissue/blood", which indirectly indicates a decrease in liver extraction of the antibiotic. Conclusion. Terrilytin in clinical practice was used topically (externally or electrophoretically), whereas our studies were conducted against the background of its parenteral administration. This obstacle can be overcome by using a polyglucine–modified form of terrilytin – terridecase, which is allowed for parenteral administration. In this regard, it is advisable to continue studying the combined drug terridecase in order to identify its ability to direct water-soluble antibiotics into the lymphatic system.

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Possibilities of using thoracoscopy under local anesthesia and proteolytic enzymes in the removal of coagulated hemothorax

Cited by 2 publications

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The importance of ultrasound in the diagnosis of pleura complications of acute destructive pneumonia in children

The importance of ultrasound in the diagnosis of pleura complications of acute destructive pneumonia in children

The Possibilities of Using Proteolytic Enzymes in Lymphotropic Therapy

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