Possibilities of pH impedance and high-resolution manometry in managing patients with refractory gastroesophageal reflux disease

Маев, И. В.; Barkalova, E. V.; Ovsepyan, M. A.; Kucheryavyi, Yu A; Andreev, D. N.

doi:10.17116/terarkh201789276-83

Cited by 20 publications

(5 citation statements)

References 31 publications

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“…Также доказано по результатам рН-импедансометрии, что частота возникновения кислых и некислых рефлюксов прямо коррелирует с показателем ИМТ [27,28].…”

Section: взаимосвязь гэрб и компонентов мс ожирениеunclassified

The relationship between gastroesophageal pathogenic reflux and metabolic syndrome

Bulgakova,

Shrayner,

Khavkin

et al. 2024

ECG

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Currently, special attention is drawn to the phenomenon of comorbidity of chronic non-infectious diseases. The emergence of comorbidity is facilitated by the high incidence of coexisting diseases. One such combination is GERD and metabolic syndrome (MS). GERD and MS are multifactorial diseases, the pathogenesis of which is intertwined and mutually aggravates each other. Every year throughout the world and the Russian Federation, there is a clear trend towards an increase in the incidence of pathology of the upper gastrointestinal tract, namely gastroesophageal reflux disease (GERD). The prevalence of obesity in Russia over 40 years of observation has increased 4 times among men and 1.5 times among women. Despite the high incidence, to date there is no diagnosis of “metabolic syndrome” (MS) in ICD-10. MS is coded based on its constituent pathologies (obesity, dyslipidemia, insulin resistance, arterial hypertension). Treatment of this comorbid pathology requires a multidisciplinary approach, thereby placing a high burden on the healthcare system. This article displays the features of the pathogenesis and clinical picture of GERD, as well as the combination of this pathology with the components of MS.

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Section: взаимосвязь гэрб и компонентов мс ожирениеunclassified

The relationship between gastroesophageal pathogenic reflux and metabolic syndrome

Bulgakova,

Shrayner,

Khavkin

et al. 2024

ECG

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“…Лише пацієнти із важкою дисплазією були включені в групу дослідження. Усім пацієнтам проводили внутрішньостравохідну рН-та імпедансометрію, а також контрастне дослідження верхнього відділу шлунково-кишкового тракту для оцінки рефлюксу в стравохід та наявності діафрагмальної грижі [4].…”

Section: матеріали та методиunclassified

Correction of cardioesophageal transition as a stage of treatment after endoscopic welding of esophageal metaplasia

Tyselskyi¹,

Кебкало²

2021

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. Barrett’s esophagus is an acquired condition that develops as a result of the replacement of normal stratified squamous epithelium in the lower part of the esophagus by columnar epithelium. Barrett’s esophagus is considered a complication of gastroesophageal reflux disease (GERD). It has been shown and proven that various endoscopic methods are successful in treating this condition. However, long-term success in preventing further metaplasia and dysplasia is incompletely studied. Biological welding – controlled action of high frequency current on living tissues. It is used to stop gastrointestinal bleeding, ablation of small intestinal metaplasia of the esophageal mucosa. The aim of this study was to evaluate the success of endoscopic treatments for Barrett's esophagus and the need for further surgery in patients with GERD complicated by Barrett’s esophagus. Patients with Barrett’s esophagus C1-3M2-4 (Prague classification 2004) and severe dysplasia without nodule, as well as confirmed GERD without esophageal hernia were included. A total of 98 patients were included in the study, of whom 89 were re-consulted and examined after primary Barrett's esophageal ablation. Endoscopic treatment was performed by argon-plasma coagulation (APC) and high-frequency welding of living tissues (HFW). In the dynamics of patients were re-examined. Patients with recurrent metaplasia and a high DeMeester index (˃100) underwent antireflux surgery – crurography (if necessary) and Nissen fundoplication with a soft and short cuff. Recurrence of small bowel metaplasia was recorded in 15 patients. 12 patients underwent a two-stage treatment: first a second session of esophageal ablation, and in the second stage - antireflux surgery. 2 patients refused surgical treatment and underwent only the second session of ablation. All patients received drug therapy – prokinetics and proton pump inhibitors. Three months after surgery, pH metry was performed again, which showed normalization of the DeMeester index, as a result of which patients had no complaints such as heartburn, chest pain, dysphagia, which significantly improved their quality of life. Esophagogastroduodenoscopy and biopsy of the mucous membrane of the lower third of the esophagus according to the Seattle protocol was also performed. After examination of the histological material of metaplasia zones were not recorded. It is concluded that antireflux surgery is required as part of Barrett’s esophageal treatment to prevent further dysplasia and the development of esophageal cancer.

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“…Диагностика большинства случаев ГЭРБ, как правило, не представляет проблем -типичная клиническая картина, особенно оптимизированная валидированными опросниками, данные эндоскопии и хороший ответ на стартовую терапию делают диагноз высоковероятным [2,5]. Рефрактерность к стандартным подходам лечения является показанием к использованию функциональных методов исследования для подтверждения ГЭРБ и изучению эффективности фармакотерапии [6], что особенно актуально ввиду неопределенных перспектив расширения портфеля средств для лечения ГЭРБ [7], за исключением, пожалуй, единственного инновационного направления последних лет -эзофагопротекции [8].…”

Section: ââåäåíèåunclassified

Development of the Russian version of quality of life questionnaire in patients with GERD – GERD-HRQL

Ionova

Nikitina

Mayevskaya

et al. 2020

Terapevticheskii arkhiv

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Gastroesophageal reflux disease (GERD) is a common chronic disease of the upper gastrointestinal tract with long course of the disease and followed by different symptoms significantly reducing quality of life (QoL) in pts. Assessment of QoL in pts with GERD may be of value for comprehensive evaluation of treatment effect as well as for monitoring of pts during treatment course in a real clinical practice. Aim. Development of the Russian version of GERD-HRQL questionnaire to assess symptomatic outcomes of GERD in research and real clinical practice. Materials and methods. GERD-HRQL questionnaire (V. Velanovich, USA) consists of 11 items: 10 items for assessment of the most frequent symptoms/problems related with QoL in pts with GERD and 1 item for assessment of patient-reported global satisfaction with health condition. Results. In accordance with international guidelines, the new language version of the tool may be used in research and clinical practice after cross cultural adaptation, linguistic validation and psychometric testing. This paper presents the results of cross-cultural adaptation and linguistic validation of the Russian version of GERD-HRQL. The following steps of linguistic and cultural adaptation of GERD-HRQL for Russia were conducted after the permission from the author of GERD-HRQL was obtained: forward translation with creation of two forward translations of GERD-HRQL in Russian, reconciliation and expert evaluation of translations of GERD-HRQL in Russian and creation of the preliminary version of GERD-HRQL in Russian, back translation, harmonization, creation of the first test-version of GERD-HRQL in Russian, cognitive debriefing and decentering, creation of the second test-version of GERD-HRQL in Russian, final expert evaluation and development of the final test-version of GERD-HRQL in Russian. Satisfactory face validity of the Russian test-version of GERD-HRQL was shown: face validity indices were 0.98, 0.95, 0.92, and 0.97. Conclusion. As the result of translation, cross cultural adaptation and linguistic validation, the Russian version of GERD-HRQL for the use in pts with GERD in Russia was developed. The Russian version of GERD-HRQL may be used in research studies and clinical practice after testing its psychometric properties.

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Possibilities of pH impedance and high-resolution manometry in managing patients with refractory gastroesophageal reflux disease

Cited by 20 publications

References 31 publications

The relationship between gastroesophageal pathogenic reflux and metabolic syndrome

The relationship between gastroesophageal pathogenic reflux and metabolic syndrome

Correction of cardioesophageal transition as a stage of treatment after endoscopic welding of esophageal metaplasia

Development of the Russian version of quality of life questionnaire in patients with GERD – GERD-HRQL

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