Possibilities of dispensary observation in reducing mortality from coronary heart disease

Boytsov, S. А.; Проваторов, С И

doi:10.26442/00403660.2023.01.202038

Cited by 7 publications

(3 citation statements)

References 25 publications

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“…Совершенствование организации медицинской помощи пациентам с инфарктом миокарда (ИМ) с подъемом сегмента ST (ИМпST) электрокардиограммы (ЭКГ), широкое внедрение современных методов реваскуляризации миокарда привели к значительному снижению смертности в данной группе пациентов [1,2]. В настоящее время госпитальная летальность пациентов с ИМпST ЭКГ в странах Европы составляет 6-14% [3,4], в РФ -10,7-13,5% [5,6].…”

Section: Introductionunclassified

Prediction of in-hospital mortality in patients aged 75 years and older with acute ST-segment elevation myocardial infarction using logistic regression and classification tree

Pereverzeva,

Yakushin

2024

Cardiovasc Ther Prev

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Aim. To study risk factors for in-hospital mortality in patients with acute myocardial infarction (MI) with ST-segment elevation (STEMI) aged ≥75 years.Material and methods. This retrospective analysis analyzed medical records of 174 patients aged ≥75 years hospitalized at the regional cardiology clinic due to STEMI in 2020-2021. There were 52 (29,9%) men. The median age for all patients was 81 [79; 85] year.Results. Inhospital mortality was 24,1%. Binary logistic regression revealed the following factors increasing the risk of inhospital mortality: cardiogenic shock (CS) — odds ratio (OR) 39,04; 95% confidence interval (CI): 8,87-171,74 (p<0,001); ventricular tachycardia (VT) — OR=60,52; 95% CI: 5,21-703,45 (p=0,001); white blood cell (WBC) count — for each increase by 1×109/l — OR=1,15; 95% CI: 1,05-1,26 (p=0,002). At the same time, history of heart failure (CHF) reduced the death risk (OR=0,04; 95% CI: 0,009-0,21 (p<0,001)). Classification tree found that 100% mortality was predicted in patients with CS and without diabetes and a history of MI and in patients with pulmonary edema and without CS, VT and HF. Mortality of 83,3% was predicted in patients without CS and without VT with a history of HF, WBC count ≥14,5×109/L and body mass index ≤23,7 kg/m2. In addition, mortality of 75,0% was predicted in patients without CS, but with VT, as well as in patients with CS without diabetes and with a history of MI. In patients with CABG and diabetes, the predicted mortality rate was 50,0%.Conclusion. The strongest factors associated with the risk of inhospital death were CS, VT, and high WBC count. The positive effect on the prognosis of pre-existing diseases, in particular HF, is apparently associated with the protective effect of previously taken therapy. This assumption needs to be confirmed based on prospective studies.

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Section: Introductionunclassified

Prediction of in-hospital mortality in patients aged 75 years and older with acute ST-segment elevation myocardial infarction using logistic regression and classification tree

Pereverzeva,

Yakushin

2024

Cardiovasc Ther Prev

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“…В настоящее время не вызывает сомнений, что дислипидемия -один из наиболее значимых модифицируемых факторов риска развития сердечнососудистых заболеваний (ССЗ) и сердечно-сосудистых осложнений (ССО) [1,2]. Отечественные и зарубеж ные кли нические рекомендации весьма конкретно определяют ключевые позиции по коррекции нарушений липидного обмена как в общей популяции, так и в отдельных клинических ситуациях [3,4].…”

Section: Introductionunclassified

New possibilities for lipid level control using inclisiran — prospects for interaction between a cardiologist and a neurologist

Skiba,

Menzorov,

Puchek

et al. 2023

Racionalʹnaâ farmakoterapiâ v kardiologii

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Dyslipidemia is one of the most significant modifiable cardiovascular risk factors. The change in the modern paradigm for dyslipidemia treatment from high-intensity statin therapy to high-intensity lipid-lowering therapy makes it possible to more often use new drug classes to achieve the target level of low-density lipoprotein cholesterol. The article presents two case reports on the use of inclisiran as part of combination lipid-lowering therapy for secondary prevention in patients at very high cardiovascular risk. Based on the presented cases, following clinical aspects of the management of cardiovascular patients are discussed: the safety of achieving low-density lipoprotein cholesterol levels below 1 mmol/l in a patient with asymptomatic cerebral infarction, the need for adequate dyslipidemia treatment after revascularization, the strategic importance of prescribing lipid-lowering therapy in patients with cerebrovascular disease to reduce the cardiovascular risk, adherence to therapy as a significant aspect of effective dyslipidemia control.

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“…населения, первичная заболеваемость -806,6 случаев на 100 тыс. человек, при этом 146,5 случаев приходится на инфаркт миокарда, а 293,6 случаев -на стенокардию напряжения [2].…”

Section: Introductionunclassified

Modern possibilities of antihypertensive and lipid-lowering therapy in the treatment of comorbid patients with a very high risk of cardiovascular events

Подзолков

Тарзиманова

Брагина

et al. 2023

Cardiovasc Ther Prev

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Hypertension and dyslipidemia are key risk factors for cardiovascular disease. Despite the currently existing possibilities for the combined use of various classes of antihypertensive and lipid-lowering drugs, the problem of treating patients with a high risk of cardiovascular events has not lost its significance and its solution in a specific clinical situation often remains very difficult. The review analyzes current data on the efficacy and safety of the fixed-dose combination of lisinopril, amlodipine and rosuvastatin to solve the problem of a personalized approach in the treatment of comorbid patients with a high risk of cardiovascular events.

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Possibilities of dispensary observation in reducing mortality from coronary heart disease

Cited by 7 publications

References 25 publications

Prediction of in-hospital mortality in patients aged 75 years and older with acute ST-segment elevation myocardial infarction using logistic regression and classification tree

Prediction of in-hospital mortality in patients aged 75 years and older with acute ST-segment elevation myocardial infarction using logistic regression and classification tree

New possibilities for lipid level control using inclisiran — prospects for interaction between a cardiologist and a neurologist

Modern possibilities of antihypertensive and lipid-lowering therapy in the treatment of comorbid patients with a very high risk of cardiovascular events

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