Possibilities of application of regenerative technologies in gynecology

Abstract

The article presents a review of publications devoted to the use of regenerative technologies in the treatment of gynecological pathologies. The authors describe possible ways to solve these problems by analyzing the experimental studies conducted in the world. Identified the main indications for tissue engineering: Ashermans syndrome, primary ovarian failure, infertility caused by chemotherapy, a niche in the uterus, endometrial pathology (endometriosis, endometrial problems, etc.), cervical pathology, female genital tract abnormalities, pelvic organ prolapse. The results of clinical trials of cell therapy aimed at treating infertility caused by Asherman syndrome and primary ovarian failure, female genital tract abnormalities, as well as such rare pathology as a niche of the uterus. At the preclinical stage, in addition to the above, considered cellular therapy of cervical pathologies, endometrial diseases and pelvic organ prolapse. Eximined cell cultures and the level of their influence on the regeneration of the female reproductive system structures, presented the biological scaffolds that stimulate the growth of stem cells, their effectiveness and shortcomings are covered.