Possibilities and perspectives of chitosan scaffolds and composites for tissue engineering

Kumar, Manish; Brar, A. S.; Vivekanand, Vivekanand; Pareek, Nidhi

doi:10.1016/b978-0-12-816909-4.00007-5

Cited by 6 publications

(8 citation statements)

References 169 publications

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“…Raman spectra registered for raw material (rGO-TEPA) and ultrasonicated rGO-TEPA after 1 and 2 h (Figure 5a), as well as the Raman spectra recorded for composite nanofibrous membranes (Figure 5b), are characterized by four specific signals: D (~1350 cm −1 ), G (~1580 cm −1 ), 2D (~2700 cm −1 ), and (D + G) (~2900 cm −1 ). The D band is associated with the occurrence of structural defects of the rGO-TEPA sheet caused by the attachment of CsA and PEO to the surface of rGO-TEPA, generating the sp 3 -carbon atoms as a result of rGO-TEPA structure modification. The G band is attributed to the stretching vibrations of sp 2 -hybridized carbon atoms from the planar structure of rGO-TEPA.…”

Section: Raman Spectrometry Resultsmentioning

confidence: 99%

“…The antibacterial activity of chitosan (CS) is provided by the presence of protonated amino (-NH 2 ) groups in acidic medium and plentiful hydroxyl (-OH) functionalities [3].…”

Section: Introductionmentioning

confidence: 99%

“…The antibacterial activity of chitosan (CS) is provided by the presence of protonated amino (-NH2) groups in acidic medium and plentiful hydroxyl (-OH) functionalities [3]. Furthermore, this biopolymer exhibits several essential characteristics which make it an appropriate material for applications in the wound dressings field, such as hemostatic activity, muco-adhesion, biocompatibility, and biodegradability, as well as low toxicity [4].…”

Section: Introductionmentioning

confidence: 99%

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Electrospun Nanofibrous Membranes Based on Citric Acid-Functionalized Chitosan Containing rGO-TEPA with Potential Application in Wound Dressings

et al. 2022

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The present research work is focused on the design and investigation of electrospun composite membranes based on citric acid-functionalized chitosan (CsA) containing reduced graphene oxide-tetraethylene pentamine (CsA/rGO-TEPA) as materials with opportune bio-properties for applications in wound dressings. The covalent functionalization of chitosan (CS) with citric acid (CA) was achieved through the EDC/NHS coupling system and was checked by 1H-NMR spectroscopy and FTIR spectrometry. The mixtures to be electrospun were formulated by adding three concentrations of rGO-TEPA into the 1/1 (w/w) CsA/poly (ethylene oxide) (PEO) solution. The effect of rGO-TEPA concentration on the morphology, wettability, thermal stability, cytocompatibility, cytotoxicity, and anti-biofilm activity of the nanofibrous membranes was extensively investigated. FTIR and Raman results confirmed the covalent and non-covalent interactions that appeared between the system’s compounds, and the exfoliation of rGO-TEPA sheets within the CsA in the presence of PEO (CsA/P) polymer matrix, respectively. SEM analysis emphasized the nanofibrous architecture of membranes and the presence of rGO-TEPA sheets entrapped into the CsA nanofiber structure. The MTT cellular viability assay showed a good cytocompatibility with the highest level of cell development and proliferation registered for the CsA/P composite nanofibrous membrane with 0.250 wt.% rGO-TEPA. The designed nanofibrous membranes could have potential applications in wound dressings, given that they showed a good anti-biofilm activity against Gram-negative Pseudomonas aeruginosa and Gram-positive Staphylococcus aureus bacterial strains.

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Section: Raman Spectrometry Resultsmentioning

confidence: 99%

“…The antibacterial activity of chitosan (CS) is provided by the presence of protonated amino (-NH 2 ) groups in acidic medium and plentiful hydroxyl (-OH) functionalities [3].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Electrospun Nanofibrous Membranes Based on Citric Acid-Functionalized Chitosan Containing rGO-TEPA with Potential Application in Wound Dressings

et al. 2022

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“…7,34 Chitosan is readily used in tissue engineering because it is characterised by features desired in biomaterials: biocompatibility, non-toxicity, the ability to biodegrade into non-toxic compounds and bioactivity. [50][51][52] It also demonstrates osteocompatibility (the presence of chitosan does not adversely affect bone regeneration) and osteoconduction (the ability to connect with bone tissue and stimulate its growth). 13 CS also has mucoadhesive properties, i.e.…”

Section: Physicochemical Propertiesmentioning

confidence: 99%

“…The antibacterial properties of chitosan may also result from the interaction with the DNA of the bacterial cell, which results in inhibition of RNA synthesis. 50,59,63…”

Section: Physicochemical Propertiesmentioning

confidence: 99%

Biomimetic scaffolds based on chitosan in bone regeneration. A review.

Kołakowska

Gadomska‐Gajadhur

Ruśkowski³

2021

Preprint

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The article focuses on a polysaccharide of natural origin – chitosan and its application in tissue engineering. The preparation process and physicochemical properties of the saccharide are described. The degradation of chitosan and the properties influencing the process both outside and in living organism were examined. Four applications in bone tissue engineering can be distinguished: preparation of cell scaffolds exclusively from chitosan, from a chitosan composite or from a chitosan polyelectrolyte complex. The fourth way is to modify the surface of scaffolds made of other materials by covering them with a layer of chitosan. At the end of the article, the processes taking place after placing the implant inside the body are described, how the structure of chitosan affects the behaviour of bone cells in the adhesion process and life processes.

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Insect Chitin and Chitosan: Structure, Properties, Production, and Implementation Prospective

Kumar

Vivekanand

Pareek

2020

Natural Materials and Products From Insects: Chemistry and Applications

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Possibilities and perspectives of chitosan scaffolds and composites for tissue engineering

Cited by 6 publications

References 169 publications

Electrospun Nanofibrous Membranes Based on Citric Acid-Functionalized Chitosan Containing rGO-TEPA with Potential Application in Wound Dressings

Electrospun Nanofibrous Membranes Based on Citric Acid-Functionalized Chitosan Containing rGO-TEPA with Potential Application in Wound Dressings

Biomimetic scaffolds based on chitosan in bone regeneration. A review.

Insect Chitin and Chitosan: Structure, Properties, Production, and Implementation Prospective

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