Positron emission tomography using fluorine-18 deoxyglucose in evaluation of coronary artery bypass grafting

Tamaki, Nagara; Yonekura, Yoshiharu; Yamashita, Keiji; Saji, Hideo; Magata, Yasuhiro; Senda, Michio; Konishi, Yutaka; Hirata, Kazuo; Ban, Toshihiko; Konishi, Junji

doi:10.1016/0002-9149(89)90832-1

Cited by 347 publications

(68 citation statements)

References 22 publications

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“…On the other hand, PPV derived from previous studies (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) that verified that the diagnostic ability of this modality was 72%.…”

Section: F-fdg Pet For Diagnosis Of Myocardial Viabilitysupporting

confidence: 52%

A Post-marketing Clinical Study to Confirm the Efficacy of <sup>18</sup>F-fluorodeoxyglucose for the Diagnosis of Myocardial Viability

Matsunari

Tamaki

Ikeda

et al. 2016

Annals of Nuclear Cardiology

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“…On the other hand, PPV derived from previous studies (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) that verified that the diagnostic ability of this modality was 72%.…”

Section: F-fdg Pet For Diagnosis Of Myocardial Viabilitysupporting

confidence: 52%

A Post-marketing Clinical Study to Confirm the Efficacy of <sup>18</sup>F-fluorodeoxyglucose for the Diagnosis of Myocardial Viability

Matsunari

Tamaki

Ikeda

et al. 2016

Annals of Nuclear Cardiology

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“…Careful analysis of myocardial perfusion in combination with viability and function can guide patienttailored therapeutic strategies (2). PET using 18 F-FDG combined with the flow tracer 13 N-ammonia is an accurate, noninvasive diagnostic technique to assess myocardial viability and ischemia in patients with chronic IHD (3,4) It has been shown that not only the extent of PET-based viable myocardium but also the extent of infarcted myocardium is an important predictor of left ventricular function recovery after revascularization (5). Most PET studies for analysis of patient survival after treatment have been based on semiquantitative scoring of myocardial perfusion and 18 F-FDG distribution.…”

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confidence: 99%

Comparison Between the Prognostic Value of Left Ventricular Function and Myocardial Perfusion Reserve in Patients with Ischemic Heart Disease

Tio¹,

Dabeshlim²,

Siebelink³

et al. 2009

J Nucl Med

178

123

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The purpose of this study was to compare the prognostic value of left ventricular ejection fraction (LVEF) and myocardial perfusion reserve (MPR) assessed with PET in patients with ischemic heart disease (IHD). Myocardial perfusion is the main determinant of left ventricular function in patients with IHD. The prognostic value of LVEF has been widely established. In addition, MPR determines survival in patients with hypertrophic and dilated cardiomyopathies. In the present study, we evaluated whether MPR also determines survival in patients with IHD. Methods: Between 1995 and 2003, 480 consecutive patients with chronic IHD underwent dipyridamole stress and rest 13 N-ammonia PET to determine MPR. Additionally, 18 F-FDG PET was performed for viability (mismatching defects), infarction (matching defects), and left ventricular function assessment. Patients were followed for all causes of mortality and major cardiovascular events. Results: In 463 of the 480 patients, valid MPR could be measured (368 men; mean age, 66 6 11 y; LVEF, 35% 6 15%). One hundred nineteen patients underwent a PET-driven revascularization (67 through percutaneous coronary intervention and 52 through coronary artery bypass grafting). The remaining 344 patients were the subject of this study. The overall MPR was 1.71 6 0.50 (intertertile boundaries, 1.49 and 1.84). After adjustment for age and sex, MPR was associated with a hazard ratio for cardiac death of 4.11 (95% confidence interval, 2.98-5.67) per SD decrease, whereas the risk for LVEF was 2.76 (2.00-3.82) per SD decrease. Conclusion: Patients with IHD with a low MPR are at high risk of cardiac death. MPR is a more sensitive predictor for cardiac death than is LVEF.

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“…The present study was designed to (1) compare the regional Tl uptake between glucose -insulinTl (GI-Tl) infusion SPECT and reinjection imaging; and (2) compare the accuracy of predicting of functional recovery by GI-Tl SPECT, reinjection imaging and low-dose dobutamine echocardiography in the same patients.…”

mentioning

confidence: 99%

Comparison of Glucose - Insulin - Thallium-201 Infusion Single Photon Emission Computed Tomography (SPECT), Stress-Redistribution - Reinjection Thallium-201 SPECT and Low Dose Dobutamine Echocardiography for Prediction of Reversible Dysfunction

et al. 2001

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ccurate detection of dysfunctional but viable myocardium has become an important component of the clinical assessment of patients with ischemic left ventricular dysfunction. Several noninvasive modalities, including positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose 1,2 thallium-201 (Tl) singlephoton emission computed tomography (SPECT) and dobutamine echocardiography, [3][4][5][6][7][8] have been developed during the past decade to detect myocardial viability, but recent studies have suggested that stress-redistribution-reinjection imaging, 7-10 rest-redistribution imaging, 6,11-14 rest technetium-99m sestamibi 12 and tetrofosmin SPECT 13 identify viable myocardium better than stress redistribution imaging. PET is still recognized as a more reliable method to evaluate myocardial viability than SPECT, but because PET is not commonly available, it is necessary to develop a more accurate and convenient method for detecting viable myocardium using SPECT. In 1993, Tartagni et al found that continuous infusion of Tl with a low dose of insulin in a glucose -potassium solution enhanced the cellular uptake Japanese Circulation Journal Vol.65, December 2001 of the radiotracer in severely ischemic regions, 15 but little is known about the usefulness of this method in predicting functional recovery. The present study was designed to (1) compare the regional Tl uptake between glucose -insulinTl (GI-Tl) infusion SPECT and reinjection imaging; and (2) compare the accuracy of predicting of functional recovery by GI-Tl SPECT, reinjection imaging and low-dose dobutamine echocardiography in the same patients. Methods PatientsPatients with coronary artery disease and resting regional left ventricular dysfunction were screened for enrolment in the study. Patients with unstable angina, uncontrolled heart failure, atrial fibrillation, and technically inadequate echocardiographic images were excluded. Twenty patients (17 men, 3 women; mean age, 66 years; Table 1) constituted the final study group. All patients had regional wall motion abnormalities on rest echocardiography: 14 patients had acute myocardial infarction (AMI <4 weeks before the study), 6 had stable angina pectoris with (n=3) or without (n=3) a previous (>6 months) MI. Of the 14 patients with AMI, 10 underwent primary percutaneous transluminal coronary angioplasty within 12 h of the onset of symptoms. Repeat angiography in the chronic phase revealed significant (≥75%) restenosis in 1 of the 10 patients, who then The usefulness of glucose -insulin -thallium-201 (GI-Tl) infusion single photon emission computed tomography (SPECT) in predicting reversible dysfunction has not been evaluated, so the present study recruited 20 patients with regional ischemic dysfunction for investigation. All patients underwent GI-Tl SPECT, post-stress Tl reinjection imaging and low dose dobutamine echocardiography. The diagnostic accuracy of these 3 techniques in predicting functional recovery was evaluated by receiver operating characteristic (ROC) analysis. In segments ...

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Positron emission tomography using fluorine-18 deoxyglucose in evaluation of coronary artery bypass grafting

Cited by 347 publications

References 22 publications

A Post-marketing Clinical Study to Confirm the Efficacy of <sup>18</sup>F-fluorodeoxyglucose for the Diagnosis of Myocardial Viability

A Post-marketing Clinical Study to Confirm the Efficacy of <sup>18</sup>F-fluorodeoxyglucose for the Diagnosis of Myocardial Viability

Comparison Between the Prognostic Value of Left Ventricular Function and Myocardial Perfusion Reserve in Patients with Ischemic Heart Disease

Comparison of Glucose - Insulin - Thallium-201 Infusion Single Photon Emission Computed Tomography (SPECT), Stress-Redistribution - Reinjection Thallium-201 SPECT and Low Dose Dobutamine Echocardiography for Prediction of Reversible Dysfunction

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