Positron Emission Tomography Study of the Effects of Tryptophan Depletion on Brain Serotonin<sub>2</sub>Receptors in Subjects Recently Remitted From Major Depression

Yatham, Lakshmi N.; Liddle, Peter F.; Sossi, Vesna; Erez, Jonathan; Vafai, Nasim; Lam, Raymond W.; Blinder, Stephan

doi:10.1001/archgenpsychiatry.2011.1493

Cited by 21 publications

(20 citation statements)

References 35 publications

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“…28 In recovered depressed patients who showed no lowering of mood after ATD, there was an ATD-induced reduction of serotonin 2 receptors. This change did not occur in patients who showed a lowering of mood.…”

Section: Recommendations For Future Researchmentioning

confidence: 99%

“…When the authors performed a similar study with an infusion of m-chlorophenylpiperazine instead of tryptophan, the results were similar, suggesting that serotonin 2A/2C receptors were upregulated. 27 Yatham and colleagues 28 followed this up by investigating whether alterations of serotonin 2 receptors might explain differences in response to ATD. They measured serotonin 2 receptors after ATD and control amino acid mixtures in newly recovered depressed patients who were being treated with selective serotonin reuptake inhibitors.…”

Section: Does Atd Lower Serotonin Function?mentioning

confidence: 99%

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Acute tryptophan depletion in humans: a review of theoretical, practical and ethical aspects

Young

2013

J Psychiatry Neurosci

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Section: Recommendations For Future Researchmentioning

confidence: 99%

Section: Does Atd Lower Serotonin Function?mentioning

confidence: 99%

Acute tryptophan depletion in humans: a review of theoretical, practical and ethical aspects

Young

2013

J Psychiatry Neurosci

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“…These data suggest that the presence of genetic factors that modify 5-HT neurotransmission may contribute to a greater likelihood of having a mood response to ATD, a finding supported by a retrospective study showing that subjects with an increased number of proposed risk genotypes for MDD have a greater chance of having the disorder [50]. Other studies in healthy subjects [8] and SSRI-treated MDD patients [9] have shown that mood response to ATD was associated with a failure to show a decrease in PET measures of 5-HT2 receptor binding during the procedure.…”

Section: Introductionmentioning

confidence: 73%

Association Study of Genotype by Depressive Response during Acute Tryptophan Depletion in Subjects Recovered from Major Depression

et al. 2015

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Purpose: To study the brief and reversible mood response to acute tryptophan depletion (ATD) as a trait marker in subjects considered at risk for major depressive disorder (MDD). Procedures: ATD was administered to 64 subjects (54 European-Americans and 10 from other races) with a personal and family history of MDD. They were in remission and had been medication-free for at least 3 months. Subjects were randomly assignment to an active or sham condition in a double-blind crossover design. They were genotyped for serotonin-related candidate genes, and mood response was quantified with the Hamilton Depression Rating Scale (HDRS). Data were analyzed using Poisson regression with repeated measures and latent trajectory models. Results: Compared to the sham controls, active ATD caused modest depressive changes showing significant main effects of test condition (χ² = 5.14, d.f. = 1, p = 0.023) and time (χ² = 12.22, d.f. = 3, p = 0.007), but no significant interaction of time and test condition. Latent trajectory analysis revealed two groups, identified as depletion responders and non-responders. Those with the HTR2A rs6313 CC genotype had significantly higher HDRS scores during ATD (χ² = 11.72, d.f. = 1, p = 0.0006). Conclusions: ATD may help identifying the biological subtypes of MDD. These data are consistent with imaging reports implicating 5-HT_2A receptor function in ATD phenotypes.

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“…neurotrophic hypothesis, etc. (Mao et al,2007;Yatham et al, 2000). Chinese medicine believes that the heart governs blood vessels, and houses the mind.…”

Section: Discussionmentioning

confidence: 99%

Study On The Anti-Depressant Effect Of Chaihu Guizhi Decoction And Its Mechinisims Of Actions

Liu¹,

Cao²,

Ding³

2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Chaihu Guizhi has the effects of treating exogenous wind-cold; alternating episodes of chills and fever; noisy nose and retching; strong headache; chest and rib-side pain, and fullness, in clinical practice, it can also be used for the treatment of depression. The objective of this paper was to study the anti-depressant effect of Chaihu Guizhi decoction and its mechanism. Materials and Methods: The anti-depressant effect of Chaihu Guizhi decoction was investigated by forced swimming test, tail suspension test and antagonism of reserpine hypothermia test in mice. Results: Chaihu Guizhi decoction could significantly shorten immobility time of mice in the forced swimming test, and dose-dependence significantly shorten immobility time of mice in the tail suspension test, after administration of 50, 100, and 200mg/kg, Chaihu Guizhi decoction, a significant dose-dependent antagonism of reserpine-induced hypothermia was observed in mice of each treatment group. Conclusion: Chaihu Guizhi decoction has an antidepressant effect.

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Positron Emission Tomography Study of the Effects of Tryptophan Depletion on Brain Serotonin₂Receptors in Subjects Recently Remitted From Major Depression

Abstract: Reduction in brain serotonin(2) receptors might be a potential compensatory mechanism to prevent tryptophan depletion-induced depressive relapse.

Cited by 21 publications

References 35 publications

Acute tryptophan depletion in humans: a review of theoretical, practical and ethical aspects

Acute tryptophan depletion in humans: a review of theoretical, practical and ethical aspects

Association Study of Genotype by Depressive Response during Acute Tryptophan Depletion in Subjects Recovered from Major Depression

Study On The Anti-Depressant Effect Of Chaihu Guizhi Decoction And Its Mechinisims Of Actions

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Positron Emission Tomography Study of the Effects of Tryptophan Depletion on Brain Serotonin2Receptors in Subjects Recently Remitted From Major Depression

Abstract: Reduction in brain serotonin(2) receptors might be a potential compensatory mechanism to prevent tryptophan depletion-induced depressive relapse.

Cited by 21 publications

References 35 publications

Acute tryptophan depletion in humans: a review of theoretical, practical and ethical aspects

Acute tryptophan depletion in humans: a review of theoretical, practical and ethical aspects

Association Study of Genotype by Depressive Response during Acute Tryptophan Depletion in Subjects Recovered from Major Depression

Study On The Anti-Depressant Effect Of Chaihu Guizhi Decoction And Its Mechinisims Of Actions

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Positron Emission Tomography Study of the Effects of Tryptophan Depletion on Brain Serotonin₂Receptors in Subjects Recently Remitted From Major Depression