Positron Emission Tomography Prospects for Clinical Utility

Rm, Kessler; Cl, Partain; Rr, Price; Ae, James

doi:10.1097/00004424-198707000-00001

Cited by 13 publications

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“…Both these techniques provide high-quality but static pictures of living tissues. Functional information about the brain can be obtained with single-photon-emission computed tomography (SPECT; Knoll, 1983) and with positronemission tomography (PET; see ter-Pogossian et , Kessler et al , 1987, and Jaszczak, 1988. A newly developed echo-planar technique allows functional imag-ing with MRI as well, with one-second time resolution (Belliveau et al , 1991;Stehling et al , 1991;Ogawa et al , 1992).…”

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Magnetoencephalography—theory, instrumentation, and applications to noninvasive studies of the working human brain

et al. 1993

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Magnetoencephalography(MEG) is a noninvasive technique for investigating neuronal activity in the living human brairi. The time resolution of the method is better than 1 ms and the spatial discrimination is, under favorable circumstances, 2 -3 mm for sources in the cerebral cortex. In MEG studies, the weak 10 fT -1 pT magnetic fields produced by electric currents fiowing in neurons are measured with multichannel SQUID {superconducting quantum interference device) gradiometers. The sites in the cerebral cortex that are activated by a stimulus can be found from the detected magnetic-field distribution, provided that appropriate assumptions about the source render the solution of the inverse problem unique. Many interesting properties of the working human brain can be studied, including spontaneous activity and signal processing following external stimuli. For clinical purposes, determination of the locations of epileptic foci is of interest. The authors begiri with a general introduction and a short discussion of the neural basis of MEG. The mathematical theory of the method is then explained in detail, followed by a thorough description of MEG instrumentation, data analysis, and practical construction of multi-SQUID devices. Finally, several MEG experiments performed in the authors laboratory are described, covering studies of evoked responses and of spontaneous activity in both healthy and diseased brains. Many MEG studies by other groups are discussed briefiy as well.

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Magnetoencephalography—theory, instrumentation, and applications to noninvasive studies of the working human brain

et al. 1993

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Positronenemissionstomographie (PET)

Hämisch¹

1997

Medizintechnik — Verfahren, Systeme Und Informationsverarbeitung

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Regional distribution of 2-deoxy-2[18F]-fluoro-D-glucose for metabolic imaging using positron emission tomography

1994

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Radiopharmaceutical availability is one of the reasons dissemination and growth of clinical PET imaging remains problematic. A 'regional' cyclotron-radiopharmacy facility for the production of the positron emitting radionuclide 2-deoxy-2[18F]-fluoro-D-glucose (FDG), has been operational for over 2 years and supplies this radiopharmaceutical to five camera facilities, four distant and one on-site. The RDS 11 MeV cyclotron is capable of dual bombardment of targets yielding 60 GBq (1600 mCi) of F-18 in a 90 minute period. F-18 labelled FDG is produced by an automated synthesis module yielding 22.2 GBq (600 mCi) FDG. The PET radiopharmacy is required to perform extensive quality assurance activities including a number of tests to insure final product and safety. [18F]FDG is shipped in unit dose vials, 6 ml, two per shielded container, meeting Department of Transportation (DOT) specifications (43 x 43 cm cubes, styrofoam packing, 22 lb. lead shield). This adheres to regulations requiring no more than 200 millirem per hour (mR/Hr) exposure at the container surface, and 10 mR/hr at a distance of 1 meter. Total transport time, utilizing private air and ground couriers, to distant facilities is approximately 100-120 minutes. Based on patient scheduling and protocol used, allowing 45-60 minutes between dose administrations, and availability of 22.2 GBq (600 mCi), 20-22 unit doses can be supplied, divided and shipped in a number of ways. The regional-commercial distribution of PET radiopharmaceuticals, specifically [18F]FDG, is feasible. This provides availability of metabolic imaging at sites distant to radiopharmaceutical production.

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Positron Emission Tomography Prospects for Clinical Utility

Cited by 13 publications

References 0 publications

Magnetoencephalography—theory, instrumentation, and applications to noninvasive studies of the working human brain

Magnetoencephalography—theory, instrumentation, and applications to noninvasive studies of the working human brain

Positronenemissionstomographie (PET)

Regional distribution of 2-deoxy-2[18F]-fluoro-D-glucose for metabolic imaging using positron emission tomography

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