Positron Emission Tomography of the Equine Distal Limb: Exploratory Study

Spriet, Mathieu; Espinosa, Patricia; Kyme, Andre; Stepanov, Pavel; Zavarzin, Val; Schaeffer, Stephen W.; Katzman, Scott A.; Galuppo, Larry D.; Beylin, David

doi:10.1111/vru.12430

Cited by 26 publications

(30 citation statements)

References 30 publications

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“…Studies in humans and equines comparing MRI findings and various joint lesions with FDG PET‐CT imaging have found associations between higher FDG avidity and MRI cartilage loss, effusion, and synovitis within symptomatic painful joint cohorts . In our study, FDG PET did not detect eight lesions of elbow osteoarthritis due to medial coronoid disease in six dogs that were diagnosed based on CT.…”

Section: Discussioncontrasting

confidence: 60%

Fluorine‐18‐fluoro‐2‐deoxy‐d‐glucose PET‐CT aids in detection of soft‐tissue injuries for dogs with thoracic or pelvic limb lameness

Frank

Mann

Duerr

2019

Vet Radiology Ultrasound

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Fluorine-18-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) provides physiologic images of tissues based on their glucose metabolism. The combination of FDG PET and CT (FDG PET-CT) has been utilized in human musculoskeletal imaging to localize soft tissue lesions, however, this modality has not been thoroughly investigated for the diagnosis of canine lameness. This prospective, descriptive study evaluated FDG PET-CT findings in 25 client-owned dogs with inconclusive origin of thoracic or pelvic limb lameness (thoracic limb n = 15/25, 60%; pelvic limb n = 6/25, 24%; and combination of both limbs n = 4/25, 16%). We hypothesized that FDG PET-CT would aid the detection of soft tissue lesions not visible with other imaging modalities. Combined FDG PET-CT detected soft tissue lesions in 40% (n = 10/25) and osteoarthritis in 64% (n = 16/25) of the patients. FDG PET detected more soft tissue lesions than contrastenhanced CT (n = 15/15, 100% and n = 12/15, 80%, respectively), while CT identified more osteoarthritis lesions than FDG PET (n = 26/26, 100% and n = 18/26, 69%, respectively). The three imaging-diagnoses based on the FDG PET component included the following: flexor carpi ulnaris muscle tear, psoas major myopathy, and tarsal desmopathy. No diagnosis for the lameness was obtained in three dogs. Findings supported FDG PET-CT as a useful adjunct imaging modality for detection of certain soft tissue injuries of the musculoskeletal system. Combined FDG PET-CT should be considered for cases where the cause of lameness is thought to be of soft tissue origin and cannot be diagnosed by conventional means. K E Y W O R D S functional imaging, myopathy, PET tracer, SUVmax, tendinopathy

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Section: Discussioncontrasting

confidence: 60%

Fluorine‐18‐fluoro‐2‐deoxy‐d‐glucose PET‐CT aids in detection of soft‐tissue injuries for dogs with thoracic or pelvic limb lameness

Frank

Mann

Duerr

2019

Vet Radiology Ultrasound

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“…An additional notable volumetric imaging modality that is receiving increasing attention as a developing technology for assessment of subchondral bone is positron emission computed tomography (PET). Recent work has demonstrated that PET is able to identify lesions that were not visible using other imaging modalities, and furthermore to distinguish between active and inactive lesions (48). As PET gains further justification, the potential applications for evaluation of subchondral bone injury will likely warrant further discussion.…”

Section: Principles Of Diagnosis and Diagnostic Imagingmentioning

confidence: 99%

The Importance of Subchondral Bone in the Pathophysiology of Osteoarthritis

2018

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Subchondral bone plays a critical role in the pathogenesis of osteochondral disease across veterinary species. The subchondral bone is highly adaptable, with the ability to model and remodel in response to loading stresses experienced by the joint. Repetitive stress injuries within the joint can result in primary or secondary pathologic lesions within the subchondral bone, which have been recognized to contribute to the development and progression of osteoarthritis. Recent advances in diagnostic imaging, particularly volumetric imaging modalities have facilitated earlier identification of subchondral bone disease. Despite these advancements, limitations in our knowledge about subchondral bone makes treatment and prevention of these conditions challenging. The purpose of this report is to review our current understanding of subchondral bone and its relationship to osteoarthritis across veterinary species, with a specific focus in the research that has been performed in horses. It can be concluded that our current understanding of subchondral bone is advancing, and future experimental, clinical and pathologic studies will provide additional insight about subchondral bone and its relationship to joint disease.

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“…Other adjunctive methods have been explored to overcome the insensitivity of soft tissue evaluation with CT: contrast-enhanced CT (CECT), positron emission tomography, spectral CT, phase contrast x-ray computed tomography and dual energy CT [49][50][51][52][53][54][55][56]. These methods improve upon and expand the physiological information usually limited with standard CT.…”

Section: Computed Tomographymentioning

confidence: 99%

Recent advances in articular cartilage evaluation using computed tomography and magnetic resonance imaging

Nelson

Kawcak

Barrett

et al. 2018

Equine Veterinary Journal

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Articular cartilage is a critical joint tissue and its evaluation remains a diagnostic challenge in horses. Coupled with a poor capacity for healing, early degenerative changes in articular cartilage are difficult to characterise using routine diagnostic imaging evaluations. Both computed tomography (CT) and magnetic resonance imaging (MRI) provide volumetric joint assessment and highlight morphological and quantitative properties of articular cartilage, improving assessment of this essential tissue. While the use of CT and MRI for joint evaluation is not new, there still remains a shortage of literature and scientific studies on the ability of these methods to evaluate articular cartilage in the horse. This review article summarises current CT and MRI techniques capable of characterising equine articular cartilage, highlights recent advances in these techniques and discusses the numerous methods studied in human subjects that have been minimally investigated in horses. Imaging techniques are presented in terms of their capabilities of offering morphological and quantitative evaluation along with a discussion of their benefits and limitations. Finally, it summarises the current state-of-the-art approaches and identifies unmet clinical imaging needs to propel the advancement of articular cartilage and joint imaging in the horse.

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Positron Emission Tomography of the Equine Distal Limb: Exploratory Study

Cited by 26 publications

References 30 publications

Fluorine‐18‐fluoro‐2‐deoxy‐d‐glucose PET‐CT aids in detection of soft‐tissue injuries for dogs with thoracic or pelvic limb lameness

Fluorine‐18‐fluoro‐2‐deoxy‐d‐glucose PET‐CT aids in detection of soft‐tissue injuries for dogs with thoracic or pelvic limb lameness

The Importance of Subchondral Bone in the Pathophysiology of Osteoarthritis

Recent advances in articular cartilage evaluation using computed tomography and magnetic resonance imaging

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