Positron Emission Tomography Is Superior to Computed Tomography Scanning for Response-Assessment After Radical Radiotherapy or Chemoradiotherapy in Patients With Non–Small-Cell Lung Cancer

Abstract

In NSCLC, a single, early, posttreatment PET scan is a better predictor of survival than CT response, stage, or pretreatment performance status.

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

“…In a prospective study, PET and CT assessments performed at a median of 70 days after RT, were concordant in only 40% of cases [81]. PET response was the best predictor of survival, was strongly-correlated with patterns of failure [82] and was not confounded by normal tissue reactions [83] .…”

Prognostic stratification using F-18 FDG PET/CT in patients with advanced stage (Stage III and IV) non-small cell lung cancer

“…Traditionally, morphologic imaging modalities had been used in the tumor response evaluation. However, morphologic imaging modalities have limitations in differentiating necrotic tumor or fibrotic tissue from residual tumor tissue [10]. Metabolic tumor response using F-18 FDG PET after chemotherapy has a significant correlation with survival in NSCLC [11].…”

The role of 18F-FDG PET/CT before and after the treatment of multiple myeloma: Our clinical experience

“…After treatment, the response evaluation by the FDG PET and FDG PET/CT has been used for many years. In 2003, in the study by Mac Manus et al [18] , each patient with non-small cell lung cancer had determinations of response to therapy made with FDG PET and CT, categorized as complete response (CR) with threshold of activity in the mediastinum, partial response (PR), no response (NR), progressive disease (PR), or non-assessable. These categories were created using the qualitative reading of the FDG PET, and with some corrections they are also …”