Positron Emission Tomography Imaging Demonstrates Correlation between Behavioral Recovery and Correction of Dopamine Neurotransmission after Gene Therapy

Abstract

In vivo gene transfer using viral vectors is an emerging therapy for neurodegenerative diseases with a clinical impact recently demonstrated in

Imaging DA release in a rat model of L-DOPA-induced dyskinesias: A longitudinal in vivo PET investigation of the antidyskinetic effect of MDMA

“…These results were confirmed by Doudet et al (2002), in a study on MPTP-treated monkeys, in which the increase in [ 11 C]raclopride BP ND was due to an increase in B avail without affecting appK d . However, in two other studies, changes in [ 11 C]raclopride BP ND in 6-OHDA lesioned rats were explained by changes in the appK d and not by B avail (Hume et al, 1995;Leriche et al, 2009). …”

In vivoQuantification of Monoamine Oxidase A in Baboon Brain: A PET Study Using [11C]befloxatone and the Multi-Injection Approach

“…We used the multi-injection approach that has proved to be a suitable method to estimate the binding site concentrations in vivo using PET: dopamine D2/D3 with fallypride and with FLB-457, benzodiazepine with flumazenil, DAT with CFT, 5-HT1A with MPPF (for review see Morris et al, 2009), neuronal nicotinic acetylcholine receptors with fluoro-A-85380 (Gallezot et al, 2008), myocardial muscarinic receptors with MQNB (Delforge et al, 1993 Leriche et al, 2009), which are more appropriate for clinical research in humans. For the above-mentioned radioligands, it was possible to estimate B max and K d separately using a multipleinjection strategy.…”

Imagerie cérébrale : outils, principes et utilisations de la clinique aux sciences cognitives comparatives

“…L'IRM et la TEP sont également utilisées chez des animaux de rente ou des primates, modèles de maladies neurodégénératives (figure 2 H-I) (Leriche et al 2009;Morton et al 2014). (Sawiak et al 2014).…”