Positron emission tomography for the early postsurgical evaluation of pediatric brain tumors

Pirotte, Benoît; Levivier, Marc; Morelli, Daniele; Bogaert, Patrick Van; Detemmerman, Dominique; David, Philippe; Balériaux, Danielle; Brotchi, Jacques; Goldman, Serge

doi:10.1007/s00381-004-1071-7

Cited by 44 publications

(23 citation statements)

References 20 publications

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“…These results suggested that MET-PET scanning is a better tool for tumor delineation than MR imaging, with not only T 1 Ϯ Gd-DTPA but also with other imaging modalities. 61 Also in the present series, the signal on FLAIR images did not correspond to accurate tumor delineation, 23 although it provided the greatest MR volume, which was more extended than the MET-PET-based volume (Class I).…”

Section: Interest In Pet Scanning-guided Neuronavigationmentioning

confidence: 93%

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Integrated positron emission tomography and magnetic resonance imaging–guided resection of brain tumors: a report of 103 consecutive procedures

Pirotte

Goldman

Dewitte

et al. 2006

JNS

Self Cite

135

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Object. The aim of this study was to evaluate the integration of positron emission tomography (PET) scanning data into the image-guided resection of brain tumors.Methods. Positron emission tomography scans obtained using fluorine-18 fluorodeoxyglucose (FDG) and L-[methyl-11C]methionine (MET) were combined with magnetic resonance (MR) images in the navigational planning of 103 resections of brain tumors (63 low-grade gliomas [LGGs] and 40 high-grade gliomas [HGGs]). These procedures were performed in 91 patients (57 males and 34 females) in whom tumor boundaries could not be accurately identified on MR images for navigation-based resection. The level and distribution of PET tracer uptake in the tumor were analyzed to define the lesion contours, which in turn yielded a PET volume. The PET scanning-demonstrated lesion volume was subsequently projected onto MR images and compared with MR imaging data (MR volume) to define a final target volume for navigation-based resection-the tumor contours were displayed in the microscope's eyepiece. Maximal tumor resection was accomplished in each case, with the intention of removing the entire area of abnormal metabolic activity visualized during surgical planning. Early postoperative MR imaging and PET scanning studies were performed to assess the quality of tumor resection. Both pre-and postoperative analyses of MR and PET images revealed whether integrating PET data into the navigational planning contributed to improved tumor volume definition and tumor resection.Metabolic information on tumor heterogeneity or extent was useful in planning the surgery. In 83 (80%) of 103 procedures, PET studies contributed to defining a final target volume different from that obtained with MR imaging alone. Furthermore, FDG-PET scanning, which was performed in a majority of HGG cases, showed that PET volume was less extended than the MR volume in 16 of 21 cases and contributed to targeting the resection to the hypermetabolic (anaplastic) area in 11 (69%) of 16 cases. Performed in 59 LGG cases and 23 HGG cases, MET-PET demonstrated that the PET volume did not match the MR volume and improved the tumor volume definition in 52 (88%) of 59 and 18 (78%) of 23, respectively. Total resection of the area of increased PET tracer uptake was achieved in 54 (52%) of 103 procedures.Conclusions. Imaging guidance with PET scanning provided independent and complementary information that helped to assess tumor extent and plan tumor resection better than with MR imaging guidance alone. The PET scanning guidance could help increase the amount of tumor removed and target image-guided resection to tumor portions that represent the highest evolving potential. KEY WORDS • neuronavigation • image-guided neurosurgery • positron emission tomography • brain tumor • stereotaxy J. Neurosurg. / Volume 104 / February, 2006HE increasing availability and routine application of image-guided neurosurgery, or neuronavigation, improves the accuracy and safety of neurosurgical interventions. It may help to optimize tumor resectio...

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Section: Interest In Pet Scanning-guided Neuronavigationmentioning

confidence: 93%

“…Therefore, MET-PET scanning was the preferred method for nonenhanced lesions suggesting LGG. Indeed, the margins of infiltrating LGGs, which are usually ill defined on MR or CT imaging, might be better visualized with MET-PET scanning 58,61 and integrated into the neuronavigational planning.…”

Section: Positron Emission Tomography Scanning Guidance For Neuronavimentioning

confidence: 99%

Integrated positron emission tomography and magnetic resonance imaging–guided resection of brain tumors: a report of 103 consecutive procedures

Pirotte

Goldman

Dewitte

et al. 2006

JNS

Self Cite

135

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“…Among amino acid PET tracers, the clinical value of MET was investigated for the early postsurgical evaluation in 20 pediatric brain tumors [34]. PET scans were typically done between 2 to 7 days after surgery.…”

Section: Pet Imaging In Pretreatment Evaluation Of Pediatric Gliomasmentioning

confidence: 99%

PET and SPECT studies in children with hemispheric low-grade gliomas

Juhász

Bosnyák

2016

Childs Nerv Syst

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Molecular imaging is playing an increasing role in the pre-treatment evaluation of low-grade gliomas. While glucose positron emission tomography (PET) can be helpful to differentiate low-grade from high-grade tumors, PET imaging with amino acid radiotracers has several advantages, such as better differentiation between tumors and non-tumorous lesions, optimized biopsy targeting and improved detection of tumor recurrence. This review provides a brief overview of single photon emission computed tomography (SPECT) studies followed by a more detailed review of clinical applications of glucose and amino acid PET imaging in low-grade hemispheric gliomas. We discuss key differences in the performance of the most commonly utilized PET radiotracers and highlight the advantage of PET/MRI fusion to obtain optimal information about tumor extent, heterogeneity and metabolism. Recent data also suggest that simultaneous acquisition of PET/MR images and the combination of advanced MRI techniques with quantitative PET can further improve the pre- and post-treatment evaluation of pediatric brain tumors.

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“…Nur wenige Arbeiten untersuchten eher beiläufig die Bedeutung von AS-PET bei Hirntumoren im Kindes-und Jugendalter. Diese, im Grunde Einzelfallbeschreibungen, weisen jedoch bereits darauf hin, dass die AS-PET auch bei pädiatrischen Patienten in der Lage ist, Hirntumoren zu detektieren, deren Ausdehnung zu bestimmen [24,31,51] und residuelles Tumorgewebe nach stattgehabter Operation zu identifizieren [33]. Die AS-PET liefert entscheidende zusätzliche Informationen zur Planung von stereotaktischen Biopsien oder navigierter Resektionen [34,42].…”

Section: Rolle Der Pet In Der Diagnostik Von Hirntumoren Im Kindes-ununclassified

Rolle der PET in der Diagnostik von Hirntumoren im Kindes- und Jugendalter

et al. 2014

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Zusammenfassung ▼Der Stellenwert der PET mit radioaktiv markierten Aminosäuren in der neuroonkologischen Diagnostik ist in vielen Studien validiert. Die Methode kann auch bei pädiatrischen Patienten zur Früherkennung von Rezidiv-/Resttumoren und vor allem zur Differenzierung eines vitalen Tumors von therapiebedingten Veränderungen eingesetzt werden. lm Rahmen einer prospektiven, multizentrischen Studie (FET PET 2010) soll die Genauigkeit der FET-PET in der Nachsorge von kindlichen Hirntumoren im Vergleich zum gegenwärtigen diagnostischen "Goldstandard" MRT vergleichen werden. Abstract ▼The value of amino acid PET in neurooncology was validated by numerous studies. This method might be useful in paediatric patients for early diagnosis of residual/recurrent tumours and especially for differentiation of the viable tumour from therapy-induced tissue changes. The aim of a multicentre prospective study (FET PET 2010) is to estimate the accuracy of FET-PET in the follow-up of paediatric brain tumours in comparison to the current diagnostic "gold standard" MRI.Heruntergeladen von: University of Florida. Urheberrechtlich geschützt. Pädiatrische Nuklearmedizin 255Plotkin M et al. Rolle der PET in … Der Nuklearmediziner 2014; 37: 254-257

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Positron emission tomography for the early postsurgical evaluation of pediatric brain tumors

Abstract: The early postoperative PET, especially with (11)C-methionine, appears to be a valid basis for complementary therapeutic decisions, especially second-look surgery, in glial tumors for which a radical resection is a key factor for prognosis.

Cited by 44 publications

References 20 publications

Integrated positron emission tomography and magnetic resonance imaging–guided resection of brain tumors: a report of 103 consecutive procedures

Integrated positron emission tomography and magnetic resonance imaging–guided resection of brain tumors: a report of 103 consecutive procedures

PET and SPECT studies in children with hemispheric low-grade gliomas

Rolle der PET in der Diagnostik von Hirntumoren im Kindes- und Jugendalter

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