Positron-Emission Tomography for Surveillance of Head and Neck Cancer

Ryan, William R.; Fee, Willard E.; Le, Quynh‐Thu; Pinto, Harlan A.

doi:10.1097/01.mlg.0000161345.23128.d4

Cited by 128 publications

(94 citation statements)

References 10 publications

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“…[3][4][5] On the basis of previously published data suggesting that 18 F-fluorodeoxyglucose (FDG)-PET offers a more accurate assessment of therapy response and earlier detection of recurrent disease than conventional imaging, our group instituted a protocol incorporating PET/CT in the follow-up of patients with head and neck cancers in July, 2005. [6][7][8][9][10][11] The goals of this study were 1) to establish the diagnostic accuracy of follow-up PET/CT in the detection of locoregional recurrence, distant metastases, and second primary tumors; and 2) to determine the impact of PET/CT on the prognosis and management of suspected disease recurrence.…”

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confidence: 99%

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

Kao

Genden

et al. 2009

Cancer

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Nitroxyl radicals were used as functionalizing agents during the free radical postreactor modification process of polyolefins carried out in the melt. The 4‐hydroxy‐2,2,6,6‐tetramethylpiperidine‐1‐oxyl (HO‐TEMPO) and the 4‐benzoyloxy‐2,2,6,6‐tetramethylpiperidine‐1‐oxyl (BzO‐TEMPO) free radicals were successfully grafted onto a polyethylene‐based material (ethylene‐co‐1‐octene copolymer) by coupling reaction with polymer macroradicals; these last were formed by H‐abstraction through peroxide addition. The macromolecular structure of the functionalized polyolefins was assessed by 1H‐NMR, FTIR spectroscopy, and SEC measurements which were used to evidence the grafting site, to evaluate the grafting level and to highlight the occurrence of chain extension through crosslinking side reactions. Indeed the use of proper model compounds allowed the preparation of accurate FTIR calibration curves for the quantitative determination of the functionalization degree. Besides the high temperature SEC analysis highlighted that this fast and simple coupling reaction between macroradicals and nitroxyl free radicals grants the grafting of functionalities onto the polyolefin backbone by contemporarily preventing the side reactions liable of the structure and MW modification of the pristine polymer. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011

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confidence: 99%

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

Kao

Genden

et al. 2009

Cancer

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“…Cela explique la différence de performances retrouvées dans la littérature entre la TEP et l'imagerie radiologique. Ainsi, pour l'évaluation de l'extension ganglionnaire, de nombreuses études ont montré les avantages de la TEP-FDG par rapport à l'imagerie classique lors du bilan d'extension initial ; cette supériorité est encore plus évidente avec les appareillages hybrides TEP-TDM [10].…”

Section: Lors Du Bilan Initialunclassified

“…Ainsi des métastases à distance, méconnues par les techniques d'imagerie, sont découvertes avec la TEP-FDG dans 10 à 20 % des cas [10]. La technique présente un intérêt pour la recherche, dans le même temps, d'une deuxième lésion maligne synchrone éventuellement due aux mêmes facteurs de risque (poumons, oesophage.…”

Section: Lors Du Bilan Initialunclassified

“…Elle est réalisée trois mois après la fin du traitement, délai nécessaire pour éviter un trop grand nombre de faux positifs induits par la cicatrisation des lésions radiques, et de faux négatifs liés au caractère microscopique de certaines lésions résiduelles. Ce délai est suffisant pour permettre la reprise du développement du cancer persistant après le traitement [10].…”

Section: Détection Précoce Des Récidivesunclassified

“…Elle permet d'identifier les patients ne présentant pas de récidive et, dans ce cas, on se limite à une surveillance clinique du patient, sans avoir à refaire une panendoscopie. Elle permet aussi d'éviter une nouvelle biopsie, souvent peu contributive, qui peut de plus favoriser le développement d'une radionécrose [10,12].…”

Section: Détection Précoce Des Récidivesunclassified

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Tomographie par émission de positrons dans la prise en charge des carcinomes épidermoïdes des VADS

Kerrary

Bertrand

Ernenwein

2010

Med Buccale Chir Buccale

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Mots clés : TEP-TDM / carcinomes des voies aérodi-gestives supérieuresRésumé -Le carcinome épidermoïde représente la forme la plus fréquente des cancers des voies aérodi-gestives supérieures (VADS). L'anatomie complexe de la région cervicofaciale rend son exploration assez difficile. Si l'imagerie conventionnelle permet d'obtenir des informations topographiques intéressantes, la médecine nucléaire avec la tomographie par émission de positrons (TEP) au [ 18 F]-fluoro-2-désoxy-Dglucose ( 18 F-FDG) constitue un progrès pour le bilan d'extension dans les aires ganglionnaires et la dé-tection de néoplasies synchrones. Sa place est appelée à devenir primordiale pour la recherche de lésions résiduelles et la détection précoce des récidives. L'évaluation de la réponse à la chimiothérapie et l'optimisation de la radiothérapie (champs et dosimétrie) constituent également des applications prometteuses car la technique de la TEP est en évolution constante. Key words: PET-CT / head and neck carcinomasAbstract -Positron emission tomography in head and neck squamous cell carcinomas. Squamous cell carcinoma is the most frequent of head and neck cancers. The complex anatomy of head and neck areas makes more difficult its exploration. If the conventional imaging provides interesting topographic informations, the contribution of the nuclear medicine through positron emission tomography (PET) with [ 18 F]-fluoro-2-deoxy-D-glucose is efficient for staging lymph nodes and detection of synchronous neoplasias. Besides, its place is also known to be essential for detecting residual lesions and early detection of recurrences. Assessment of tumor response to treatment with chemotherapy and optimization fields and dosimetry in radiotherapy are also proving to be full of promising applications especially because the technique by PET is in constant evolution. Généralités et épidémiologie

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Ability of Positron Emission Tomography to Detect Residual Neck Node Disease in Patients With Head and Neck Squamous Cell Carcinoma After Definitive Chemoradiotherapy

Tan¹,

Adelstein²,

Rybicki³

et al. 2007

Arch Otolaryngol Head Neck Surg

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To report our experience using the neck examination, computed tomography (CT), and positron emission tomography (PET) to clinically evaluate nodepositive patients with head and neck squamous cell cancer for residual neck node disease after definitive chemoradiotherapy. Design: Retrospective review of all Cleveland Clinic patients with head and neck squamous cell cancer and N2 or N3 neck node involvement at presentation who were treated with definitive concurrent chemoradiotherapy and who underwent clinical restaging after treatment using the neck examination, CT, and PET. Setting: Tertiary care referral institution. Patients: Forty-eight patients with 72 positive necks at diagnosis were followed up for a median of 20 months. Main Outcome Measures: Palpable nodes on examination, nodes larger than 1 cm, nodes with central necrosis on CT, or any hypermetabolic lymph nodes on PET were considered clinical evidence of residual nodal disease. The true rate of pathologic involvement was determined by histologic examination after planned neck dissection or if regional recurrence developed. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated for all 3 clinical assessment tools.

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Positron-Emission Tomography for Surveillance of Head and Neck Cancer

Cited by 128 publications

References 10 publications

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

Tomographie par émission de positrons dans la prise en charge des carcinomes épidermoïdes des VADS

Ability of Positron Emission Tomography to Detect Residual Neck Node Disease in Patients With Head and Neck Squamous Cell Carcinoma After Definitive Chemoradiotherapy

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