Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems

Vaquero, J.J.; Kinahan, Paul E.

doi:10.1146/annurev-bioeng-071114-040723

Cited by 280 publications

(212 citation statements)

References 107 publications

(118 reference statements)

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“…The formation of a semi-stable zincblende structure is possible through epitaxial growth on a substrate with a cubic lattice, while a stable rocksalt structure is only achievable at pressures greater than 9 GPa 37 . The material density of ZnO is 5.61 g/cm 3 , which is substantially less than that of conventional heavy-metal oxide scintillators, but is greater than that of plastic scintillators 38 .…”

Section: Zno Propertiesmentioning

confidence: 88%

“…Anatomical imaging of the physical structures within the human body has now reached unparalleled precision with submillimeter spatial resolution for both magnetic resonance imaging (MRI) 1 and computerized tomography (CT) 2 . However, the highest spatial resolution currently possible for visualizing metabolic processes is approximately 3 cm with positron emission tomography (PET) 3 . Furthermore, PET scans are much blurrier and exhibit more poorly defined boundaries than conventional imaging systems 4 , and if combined with the lack of clearly defined anatomical landmarks, the clinical usefulness of PET scans can be greatly reduced 5 .…”

Section: Motivationmentioning

confidence: 99%

“…The most commonly used radioactive glucose analog is [ 18 F-2-fluoro-2-deoxyglucose], or FDG 3 . This compound contains the radioactive isotope fluorine-18 that has a half-life of 110 minutes.…”

Section: Overview Of Scintillation In Pet Scansmentioning

confidence: 99%

“…As the fluorine-18 decays into a stable oxygen-18 atom, it emits a positron that annihilates with a localized electron, generating two 511 keV gamma rays 180 degrees apart. The detectors then localize the annihilation event along the line of response based on the difference in timing between the two gamma-ray detections 3 .…”

Section: Overview Of Scintillation In Pet Scansmentioning

confidence: 99%

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Zinc oxide nanowire gamma ray detector with high spatiotemporal resolution

et al. 2016

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To my mom, Linda.iii ACKNOWLEDGEMENTSThere are no words to express how grateful I am for all the people that have been part of my life during this journey. I could not have completed my PhD without their help, and I would first like to thank the two advisors that guided me through my graduate career.Professor Richard Mu accepted me as an REU student during my final summer as an undergraduate. After interacting with his group and getting a chance to do actual research in a lab, I changed my graduate path from computational physics to experimental physics and never looked back. Professor Mu's group has always felt like an extended family, where the members worked hard and helped each other without question. I also learned humility in his groupcelebrate the victories in the lab, but be mindful of the people and path that led to that point. I honestly can't begin to express how much I appreciate everything he has done to help me and my family over the years. He has been there through all of the ups and downs in my personal and professional life, and I am honored for the chance to continue to work with him in the future.Professor Richard Haglund accepted me into his group at Vanderbilt after I finished my Master's at Fisk University. I struggled at the beginning while trying to balance course work with research and family, and he gave me some of the best advice I've ever received. He told me that my future was in my hands and that I would fail or succeed based on my own actions. That motivated me to work harder than I had ever worked and is something I still carry with me today.I also want to thank Professor Haglund for instilling within me a deeper appreciation for the elegance of physics, from cascade lasers to perturbation theory. His depth of knowledge and work-life balance are inspiring, and I look forward to working with him in future projects. My mom and dad worked extremely hard to provide a solid foundation for me and my brother. I couldn't ask for better parents. My dad worked to provide for our family, and my mom put her career on hold to stay home with me and my brother. They encouraged us to reach for the stars and to always choose the right path, even if it was the more difficult one. I am who I am today due in large part to the sacrifices, encouragement, and love that my parents provided.

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Section: Zno Propertiesmentioning

confidence: 88%

Section: Motivationmentioning

confidence: 99%

Section: Overview Of Scintillation In Pet Scansmentioning

confidence: 99%

Section: Overview Of Scintillation In Pet Scansmentioning

confidence: 99%

See 2 more Smart Citations

Zinc oxide nanowire gamma ray detector with high spatiotemporal resolution

et al. 2016

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“…For a recent comprehensive review of PET technology, image reconstruction, and applications, see Ref. 3.…”

Section: Introductionmentioning

confidence: 99%

History and future technical innovation in positron emission tomography

2017

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Abstract. Instrumentation for positron emission tomography (PET) imaging has experienced tremendous improvements in performance over the past 60 years since it was first conceived as a medical imaging modality. Spatial resolution has improved by a factor of 10 and sensitivity by a factor of 40 from the early designs in the 1970s to the high-performance scanners of today. Multimodality configurations have emerged that combine PET with computed tomography (CT) and, more recently, with MR. Whole-body scans for clinical purposes can now be acquired in under 10 min on a state-of-the-art PET/CT. This paper will review the history of these technical developments over 40 years and summarize the important clinical research and healthcare applications that have been made possible by these technical advances. Some perspectives for the future of this technology will also be presented that promise to bring about new applications of this imaging modality in clinical research and healthcare.

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Chemical Reaction Engineering Methodologies for Biomedical Imaging Analysis

Kawahara

2018

Biomedical Engineering Challenges

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Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems

Cited by 280 publications

References 107 publications

Zinc oxide nanowire gamma ray detector with high spatiotemporal resolution

Zinc oxide nanowire gamma ray detector with high spatiotemporal resolution

History and future technical innovation in positron emission tomography

Chemical Reaction Engineering Methodologies for Biomedical Imaging Analysis

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