Positron emission tomography/computed tomography with ¹⁸fluoro‐deoxyglucose in the detection of local recurrence and distant metastases of pediatric sarcoma

Abstract

FDG-PET/CT may be useful and complementary to other imaging modalities for the detection of recurrent pediatric sarcomas, especially at the primary site. Its potential advantages and limitations compared with conventional imaging modalities need to be further investigated in larger homogenous patient groups.

Positron emission tomography for the evaluation of soft-tissue sarcomas and bone sarcomas

“…This was demonstrated by Arush et al [12] on a series of 19 patients, who presented a FDG-PET scan that helped in the correct interpretation of conventional imaging findings and was able to detect otherwise unknown metastasis in two patients. Some groups, however, tested different radiopharmaceuticals to understand if there may be somehow an added value in comparison to FDG.…”

Value of18F-FDG PET and PET/CT for Evaluation of Pediatric Malignancies

“…Arush et al reported a high accuracy of 18 F-FDG PET/CT in the detection of local recurrence (95%) of Ewing sarcomas, osteosarcomas, and rhabdomyosarcomas on follow-up scans (Fig. 4B) (95). In the case of a new soft-tissue lesion on conventional imaging scans, which is of low suspicion for residual or recurrent disease, an 18 F-FDG PET/CT examination may be reassuring to exclude disease and avoid biopsy.…”

Imaging Osteosarcoma

“…FDG-PET scanning depicts significant additional information in staging of pediatric sarcoma, which has a relevant impact on treatment planning when compared with other conventional imaging modalities [52]. FDG-PET/CT has a complementary role in the establishment of local recurrence and distant metastases in pediatric sarcomas [53].…”