Positron Emission Tomography/Computed Tomography for Gynecologic Malignancies

Oldan, Jorge; Patel, Parth

doi:10.1097/ogx.0000000000000345

Cited by 12 publications

(3 citation statements)

References 87 publications

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“…18 F-FDG PET/CT is useful for the assessment ovarian cancer recurrence [18]. It is able to find lesions in many instances in which CT alone is negative, and it is able to detect disease recurrence 6 months before findings can be seen on CT [19].…”

Section: Discussionmentioning

confidence: 99%

Leptomeningeal carcinomatosis and bilateral internal auditory canal metastases from ovarian carcinoma

Krupa

Byun

2017

Radiology Case Reports

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Ovarian cancer, a leading cause of death in women, typically spreads locally and rarely metastasizes to the brain or seeds the leptomeninges. We present a case of a 62-year-old woman with a history of treated ovarian cell carcinoma who developed bilateral sensorineural deafness and right-sided facial weakness and on imaging was found to have bilateral internal auditory canal (IAC) masses and leptomeningeal carcinomatosis, pathologically proven by cerebrospinal fluid cytology. We discuss her magnetic resonance imaging and positron emission tomography-computed tomography findings and review the imaging characteristics of IAC metastases. Finally, we review the literature on leptomeningeal carcinomatosis from ovarian cancer and discuss the high incidence of bilateral IAC metastases in patients with leptomeningeal carcinomatosis.

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Section: Discussionmentioning

confidence: 99%

Leptomeningeal carcinomatosis and bilateral internal auditory canal metastases from ovarian carcinoma

Krupa

Byun

2017

Radiology Case Reports

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“…Given that these techniques can be used to visualize vascularization and glucose transport, which are characteristics of malignant cells, they are useful (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Gliomatosis peritonei with 18F-fluorodeoxyglucose accumulation and contrast enhancement secondary to immature teratoma: A case report

et al. 2018

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Abstract. Gliomatosis peritonei (GP) is a rare condition characterized by mature glial tissue implants widespread in the peritoneum, which is occasionally followed by treatment for immature teratoma (IM). The present study reported a case of GP with fluorodeoxyglucose (FDG) accumulation and contrast enhancement followed by treatment for IM. A 30-year-old female, 2-gravida and 0-para, underwent laparotomy with hysterectomy, bilateral salpingo-oophorectomy, and partial omentectomy followed by four cycles of chemotherapy with bleomycin, etoposide, and cisplatin for IM (Grade 2) of stage IIIC. At the 6-month follow-up, computed tomography (CT) revealed a 1-cm mass with contrast enhancement on splenic flexure. Positron-emission tomography (PET)/CT revealed intense FDG accumulation at the same site. Although α-fetoprotein, which was elevated preoperatively, remained normal, she was diagnosed with IM recurrence. The patient underwent three cycles of chemotherapy with paclitaxel, ifosfamide, and cisplatin, but the size, the degree of contrast enhancement and FDG accumulation of the mass did not change after chemotherapy. A diagnostic laparoscopy was performed. which revealed multiple small peritoneal implants, including a 1-cm mass at the splenic flexure. The 1-cm mass was dissected at the splenic flexure and some other implants. Mature well-differentiated glial tissue with non-atypia was identified in all tissue, and a diagnosis of GP was made. The patient is currently undergoing regular follow-up. Few reports are available regarding FDG-PET/CT imaging of GP. GP should be considered as the differential diagnosis of FDG-avid mass followed by IM therapy. A laparoscopic diagnosis is useful to obtain an accurate diagnosis of GP.

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“…Therefore, early diagnosis and treatment of an ovarian tumor is very important. For the differentiation of ovarian masses and the decision to apply surgery, the diagnostic methods to be used include physical examination, biochemical markers (5), ultrasonography (US) (6,7), magnetic resonance imaging (MRI) (8), positron emission tomography (PET) (9) and computed tomography (CT) (8,9). In previous studies, it has been reported that MRI is superior to CT and US in the differential diagnosis of ovarian masses but that there was no difference between these methods in malignantbenign differentiation (10).…”

Section: Introductionmentioning

confidence: 99%

Value of Multiple Computed Tomography Criteria for Prediction of Malignancy in Patients with Ovarian Mass

Öztoprak

Karakuş

2018

Gynecol Obstet Reprod Med

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OBJECTIVE:Computed tomography can be used as a safe, accurate and noninvasive technique for the prediction of ovarian malignancy with several criteria. We aimed to determine the sensitivity and specificity of presence of multiple computed tomography malignancy criteria for the prediction of ovarian malignancy in patients with ovarian mass.STUDY DESIGN: From a total of 734 patients diagnosed with an adnexal mass, ovarian mass was determined in 91 contrast-enhanced abdominopelvic computed tomography images were examined for the presence of tumoral diameter (>50 mm), thick septa, wall thickness, solid component, contrast involvement, invasion, ascites, and bilaterality. The ratios of these parameters and the value of their combined use for the prediction of ovarian malignancy was assessed. RESULTS:Of the 91 patients included in the study, in patients with benign [in 66 (72.5%) patients] and malign [(in 25 (27.5%) patients] ovarian mass, the mean (range) ages were 43.5 (17-82) and 58.0 (34-88) years, respectively. A statistically significant relationship was determined between ovarian malignancy and all the computed tomography criteria (p<0.05) except the tumoral diameter (>50 mm) and wall thickness (p>0.05). The ROC analysis revealed that with the presence of 3 or more criteria among the 8 computed tomography criteria, the ovarian mass can be predicted as malignant at least with a sensitivity of 76% and specificity of 70%. CONCLUSION:The presence of 3 or more parameters among the 8 selected computed tomography criteria, the ovarian malignancy can be predicted at least with a sensitivity of 76% and specificity of 70% in patients with ovarian mass.

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Positron Emission Tomography/Computed Tomography for Gynecologic Malignancies

Abstract: PET/CT plays an important role in detection of initial disease and recurrence of gynecologic malignancies.

Cited by 12 publications

References 87 publications

Leptomeningeal carcinomatosis and bilateral internal auditory canal metastases from ovarian carcinoma

Leptomeningeal carcinomatosis and bilateral internal auditory canal metastases from ovarian carcinoma

Gliomatosis peritonei with 18F-fluorodeoxyglucose accumulation and contrast enhancement secondary to immature teratoma: A case report

Value of Multiple Computed Tomography Criteria for Prediction of Malignancy in Patients with Ovarian Mass

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