Positron emission tomography/computed tomography as a clinical diagnostic tool for anterior mediastinal tumors

Watanabe, Tatsuaki; Sasaki, Hideo; Mutoh, Tatsushi; Saito, Ryoko; Goto, Ryoi; Yamada, Takehiro; Notsuda, Hirotsugu; Matsuda, Yasushi; Noda, Masafumi; Sakurada, Akira; Taki, Yasuyuki; Okada, Yoshinori

doi:10.1007/s00595-018-1712-1

Cited by 28 publications

(20 citation statements)

References 22 publications

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“…Furthermore, the opinion of Ito et al ( 15 ) is that there is a statistically significant difference in the SUVmax between thymic carcinoma and high-grade thymoma, among high-grade and low-grade thymomas, and that the 18 FDG PET/CT scan could predict tumor invasion into pericardium, lungs, and brachiocephalic vein ( 15 ). Watanabe et al ( 16 ) presented that the 18 FDG PET scan can differentiate thymoma from thymic cancer, diffuse large B-cell lymphoma, and Hodgkin's lymphoma, whereas the SUVmax of the lesion cannot predict the histological diagnosis of thymoma ( 16 ). Terzi et al ( 11 ) evaluated the SUVmax of the lesion, the SUVmax of the mediastinum, and the ratio of these two variables.…”

Section: Discussionmentioning

confidence: 99%

Can the Ratio SUVmax of the Lesion/SUVmax of Mediastinal Tissues Guide the Choice of Surgical Access for the Resection of Thymic Epithelial Tumors?

Moraitis¹,

Agrafiotis

Skoura³

et al. 2022

Front. Surg.

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BackgroundThere are studies showing the utility of the 18-fluorodeoxyglucose positron emission tomography (18FDG PET) scan in the management of patients with thymic epithelial tumors. It seems to be a correlation between the standard uptake value (SUVmax) of thymic epithelial tumors and the histological type and the stage. This study aims to use the ratio of the SUVmax of the lesion to the SUVmax of the adjacent mediastinal tissues in order to guide the choice of the surgical access.MethodsAll patients who presented an anterior mediastinal lesion with a high suspicion of being of thymic origin were included in a prospective database. A ratio inferior to 1 could predict a benign nature and less aggressive behavior, and a minimally invasive approach was performed. A ratio superior to 1 suggested a malignant and aggressive behavior, and a median sternotomy (or a thoracotomy) was performed.ResultsThere were 15 male (mean age 44.6 ± 16.26 years, range 25–73) and 15 female patients (mean age 50.1 ± 16.94 years, range 25–76). When the ratio is inferior to 1, it predicts benign disease in 80% of cases. When it is superior to 1, it predicts in half of cases advanced histological types (high risk thymomas and thymic carcinomas). On the contrary, it can quite accurately predict advanced Masaoka–Koga stages.ConclusionsThe protocol of this study is in accordance with the current literature showing the utility of 18FDG PET scan in the treatment of thymic epithelial tumors. This study goes one step further since the choice of surgical access is based on the SUVmax values. The ratio SUVmax of the lesion/SUVmax of the mediastinal tissues could be a new marker, more pertinent than absolute SUVmax values.

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Section: Discussionmentioning

confidence: 99%

Can the Ratio SUVmax of the Lesion/SUVmax of Mediastinal Tissues Guide the Choice of Surgical Access for the Resection of Thymic Epithelial Tumors?

Moraitis¹,

Agrafiotis

Skoura³

et al. 2022

Front. Surg.

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“…Somatostatin single-photon emission computerized tomography may also be used. PET/CT findings provide useful information for the differential diagnosis of anterior mediastinal masses [5] .…”

Section: Discussionmentioning

confidence: 99%

Carcinoid tumor of the anterior mediastinum in a 38-year-old woman

Abelian

Akano

Penha

et al. 2020

Radiology Case Reports

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Mediastinal neuroendocrine tumors (NETs) are very rare. They have been estimated to account for approximately 2%-4% of all anterior mediastinal neoplasms. Carcinoid tumors are a type of NET that can occur in a number of locations. They arise from endocrine amine precursor uptake and decarboxylation cells that can be found in organs such as the lungs. In general, they are slow growing tumors but are nevertheless capable of metastasizing. We present the case of a carcinoid tumor of the anterior mediastinum in a 38-year-old woman presented to our hospital with a 4-month history of worsening breathless and cough. Definitive diagnosis was based on histopathological examination and immunophenotypic markers.

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“…[ 7 ] Considering the increasing prevalence of isolated single lobe hyperplasia of the thyroid gland, might be consider as a new entity. PET/CT findings provide useful information for the differential diagnosis of anterior mediastinal masses[ 8 ] and might help in diagnosing the isolated single lobe hyperplasia of the thyroid gland.…”

Section: Discussionmentioning

confidence: 99%

Isolated single lobe hyperplasia of the thyroid gland, presenting as anterior mediastinal mass, detected on positron emission tomography-computed tomography scan

et al. 2020

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We report a case who presented with facial swelling and breathlessness. Recent chest X-ray was suggestive of soft-tissue in the mediastinum. In view of the suspicion of mass being neoplastic, the patient was referred for positron emission tomography-computed tomography (PET-CT) scan. Whole-body fluorodeoxyglucose (FDG) PET-CT scan revealed a mildly FDG-avid large lobulated soft-tissue mass in the anterior mediastinum, seen to arising from right lobe of the thyroid gland, extending into the right hemithorax. Histopathological examination of the mass was compatible with adenomatous hyperplasia of the thyroid. Here, we report an unusual case of isolated single lobe hyperplasia of the thyroid gland, masquerading as an anterior mediastinal mass.

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Positron emission tomography/computed tomography as a clinical diagnostic tool for anterior mediastinal tumors

Abstract: Although the SUVmax of each disease overlapped, PET/CT findings provided useful information for the differential diagnosis of anterior mediastinal masses.

Cited by 28 publications

References 22 publications

Can the Ratio SUVmax of the Lesion/SUVmax of Mediastinal Tissues Guide the Choice of Surgical Access for the Resection of Thymic Epithelial Tumors?

Can the Ratio SUVmax of the Lesion/SUVmax of Mediastinal Tissues Guide the Choice of Surgical Access for the Resection of Thymic Epithelial Tumors?

Carcinoid tumor of the anterior mediastinum in a 38-year-old woman

Isolated single lobe hyperplasia of the thyroid gland, presenting as anterior mediastinal mass, detected on positron emission tomography-computed tomography scan

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