Positron emission tomography-computed tomography and 4-hydroxynonenal-histidine immunohistochemistry reveal differential onset of lipid peroxidation in primary lung cancer and in pulmonary metastasis of remote malignancies

Živković, Nevenka Piskač; Petrovečki, Mladen; Lončarić, Čedna Tomasović; Nikolić, Igor; Waeg, Georg; Jaganjac, Morana; Žarković, Kamelija; Žarković, Neven

doi:10.1016/j.redox.2017.01.005

Cited by 20 publications

(16 citation statements)

References 43 publications

(49 reference statements)

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“…In support of this is the recent finding that 4-HNE production is increased in non-malignant cells in the vicinity of human hepatocellular carcinoma or lung metastases of remote cancer. This highlights the possible role of 4-HNE as a natural anti-cancer substance as well as a detrimental factor in (neuro) degenerative and inflammatory processes [64][65][66][67][68]. Finally, the quantities of 4-HNE protein adducts are of high importance for the cytotoxic/apoptotic effects of 4-HNE since they represent a reservoir for the persistent presence of 4-HNE, even in the absence of oxidative stress [65,69].…”

Section: Ros-dependent Lipid Peroxidation Productsmentioning

confidence: 99%

Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis

et al. 2020

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Apoptosis is the physiological mechanism of cell death and can be modulated by endogenous and exogenous factors, including stress and metabolic alterations. Reactive oxygen species (ROS), as well as ROS-dependent lipid peroxidation products (including isoprostanes and reactive aldehydes including 4-hydroxynonenal) are proapoptotic factors. These mediators can activate apoptosis via mitochondrial-, receptor-, or ER stress-dependent pathways. Phospholipid metabolism is also an essential regulator of apoptosis, producing the proapoptotic prostaglandins of the PGD and PGJ series, as well as the antiapoptotic prostaglandins of the PGE series, but also 12-HETE and 20-HETE. The effect of endocannabinoids and phytocannabinoids on apoptosis depends on cell type-specific differences. Cells where cannabinoid receptor type 1 (CB1) is the dominant cannabinoid receptor, as well as cells with high cyclooxygenase (COX) activity, undergo apoptosis after the administration of cannabinoids. In contrast, in cells where CB2 receptors dominate, and cells with low COX activity, cannabinoids act in a cytoprotective manner. Therefore, cell type-specific differences in the pro- and antiapoptotic effects of lipids and their (oxidative) products might reveal new options for differential bioanalysis between normal, functional, and degenerating or malignant cells, and better integrative biomedical treatments of major stress-associated diseases.

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Section: Ros-dependent Lipid Peroxidation Productsmentioning

confidence: 99%

Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis

et al. 2020

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“…Such an increased resistance to oxidative stress could be one of the major advantages acquired by the transforming cells allowing them more efficient bypass of ROS damage while also giving them an important leverage compared to normal cells in the fighting chances for survival [45] . On the other hand, cancer invasion as well as inflammatory response to cancer can also induce lipid peroxidation in adjacent non-malignant tissue that can response by increased lipid peroxidation generating cytotoxic lipid peroxidation product HNE to defend themselves and the organism against invading cancer even by formation of the protein adducts of HNE [61] , [62] . Hence, it is not surprising that among common metabolic features of cancer cells is alteration of the biomembrane lipid profile by reducing PUFAs to prevent lipid peroxidation, since thus generated HNE can exert more potent cytotoxic, pro-necrotic and pro-apoptotic effects for cancer than for nonmalignant cells, also regulating activities of numerous genes, enzymes and cytokines involved in the growth regulation and oxidative homeostasis [63] , [64] .…”

Section: Oxidative Stress and Cancer Metabolic Switchmentioning

confidence: 99%

Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer

et al. 2018

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Association of oxidative stress with carcinogenesis is well known, but not understood well, as is pathophysiology of oxidative stress generated during different types of anti-cancer treatments. Moreover, recent findings indicate that cancer associated lipid peroxidation might eventually help defending adjacent nonmalignant cells from cancer invasion. Therefore, untargeted metabolomics studies designed for advanced translational and clinical studies are needed to understand the existing paradoxes in oncology, including those related to controversial usage of antioxidants aiming to prevent or treat cancer. In this short review we have tried to put emphasis on the importance of pathophysiology of oxidative stress and lipid peroxidation in cancer development in relation to metabolic adaptation of particular types of cancer allowing us to conclude that adaptation to oxidative stress is one of the main driving forces of cancer pathophysiology. With the help of metabolomics many novel findings are being achieved thus encouraging further scientific breakthroughs. Combined with targeted qualitative and quantitative methods, especially immunochemistry, further research might reveal bio-signatures of individual patients and respective malignant diseases, leading to individualized treatment approach, according to the concepts of modern integrative medicine.

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“…Such a confusing findings indicating possible negative association of oxidative protein modifications and no MDA and 8-OHdG changes in PTSD indicate the need to study in particular the metabolism of HNE and the levels of HNE-His adducts in PTSD patients. Namely, the association of HNE and in particular its adducts to proteins, such as albumin, were found to be potentially very reliable biomarker of tissue specific and systemic lipid peroxidation associated with metabolic disorders, cancer and inflammatory processes including neuroborreliosis and encephalitis, which were found to be associated with systemic metabolic alterations, both reflecting like HNE-His disease progression and the efficacy of therapies used [19] , [25] , [36] , [50] , [51] , [58] , [77] , [97] .…”

Section: Depressionmentioning

confidence: 99%

Short overview on metabolomic approach and redox changes in psychiatric disorders

et al. 2018

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Schizophrenia, depression and posttraumatic stress disorder (PTSD) are severe mental disorders and complicated diagnostic entities, due to their phenotypic, biological and genetic heterogeneity, unknown etiology, and poorly understood alterations in biological pathways and biological mechanisms. Disturbed homeostasis between overproduction of oxidant species, overcoming redox regulation and a lack of cellular antioxidant defenses, resulting in free radical-mediated pathology and subsequent neurotoxicity contributes to development of depression, schizophrenia and PTSD, their heterogeneous clinical presentation and resistance to treatment. Metabolomics is a discipline that combines different strategies with the aim to extract, detect, identify and quantify all metabolites that are present in a biological sample and might provide mechanistic insights into the etiology of various psychiatric disorders. Therefore, oxidative stress research combined with metabolomics might offer a novel approach in dissecting psychiatric disorders, since these data-driven but not necessarily hypothesis-driven methods might identify new targets, molecules and pathways responsible for development of schizophrenia, depression or PTSD. Findings from the oxidative research in psychiatry together with metabolomics data might facilitate development of specific and validated prognostic, therapeutic and clinical biomarkers. These methods might reveal bio-signatures of individual patients, leading to individualized treatment approach. In reviewing findings related to oxidative stress and metabolomics in selected psychiatric disorders, we have highlighted how these novel approaches might make a unique contribution to deeper understanding of psychopathological alterations underlying schizophrenia, depression and PTSD.

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Positron emission tomography-computed tomography and 4-hydroxynonenal-histidine immunohistochemistry reveal differential onset of lipid peroxidation in primary lung cancer and in pulmonary metastasis of remote malignancies

Cited by 20 publications

References 43 publications

Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis

Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis

Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer

Short overview on metabolomic approach and redox changes in psychiatric disorders

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