Positron Emission Tomography-Based Molecular Imaging in Human Cancer

Larson, Steven M.

doi:10.1158/1078-0432.ccr-0002-4

Cited by 31 publications

(18 citation statements)

References 19 publications

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“…Since hypoxia in tumours and internalization of high levels of glucose into tumours are considered to be indicators of more aggressive tumours, and thus of poor patient prognosis [48], attempts to detect these characteristics in patients' tumours have been developed using positron emission tomography (PET). Hypoxic zones are detected after injection of [fluorine-18] misonidazole (FMISO), while tumours that capture glucose can be detected after injection of [fluorine-18] deoxyglucose (FDG), a non- Fig.…”

Section: Clinical Significance Of Hypoxia Hif and Hif Downstream Genmentioning

confidence: 99%

Hypoxia and cancer

2007

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A major feature of solid tumours is hypoxia, decreased availability of oxygen, which increases patient treatment resistance and favours tumour progression. How hypoxic conditions are generated in tumour tissues and how cells respond to hypoxia are essential questions in understanding tumour progression and metastasis. Massive tumour-cell proliferation distances cells from the vasculature, leading to a deficiency in the local environment of blood carrying oxygen and nutrients. Such hypoxic conditions induce a molecular response, in both normal and neoplastic cells, that drives the activation of a key transcription factor; the hypoxia-inducible factor. This transcription factor regulates a large panel of genes that are exploited by tumour cells for survival, resistance to treatment and escape from a nutrient-deprived environment. Although now recognized as a major contributor to cancer progression and to treatment failure, the precise role of hypoxia signalling in cancer and in prognosis still needs to be further defined. It is hoped that a better understanding of the mechanisms implicated will lead to alternative and more efficient therapeutic approaches.

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Section: Clinical Significance Of Hypoxia Hif and Hif Downstream Genmentioning

confidence: 99%

Hypoxia and cancer

2007

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“…Increased FDG-PET uptake can also reflect increased glycolysis due to focal ischemia. 12,34,35 In high-grade glial tumors, the areas of ischemia would be located where the increasing metabolic demands of rapidly growing cells are outstripping the vascular supply, causing the cells to switch to glycolysis.…”

Section: Possible Explanationsmentioning

confidence: 99%

Apparent Diffusion Coefficient of Glial Neoplasms: Correlation with Fluorodeoxyglucose–Positron-Emission Tomography and Gadolinium-Enhanced MR Imaging

Holodny¹,

Makeyev²,

Beattie³

et al. 2010

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Gd-enhancement provides essential information in the assessment of brain tumors. However, enhancement does not always correlate with histology or disease activity, especially in the setting of current therapies. Our aim was to compare FDG-PET scans to ADC maps and Gd-enhanced MR images in patients with glial neoplasms to assess whether DWI might offer information not available on routine MR imaging sequences and whether such findings have prognostic significance.

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“…The higher metabolic rate could be routinely measured by positron emission tomography (PET) [110]. The reaction rate of the simple fermentative reaction could be 100 times quicker (approximated from the positron annihilation data) [111] than the oxidative way. However, the oxidative way has an at least 18 times higher efficacy due to the ATP amount at the end.…”

Section: Transport Propertiesmentioning

confidence: 99%

Connections between Warburg’s and Szentgyorgyi’s Approach about the Causes of Cancer

Gp¹,

Szász²,

Hegyi³

2016

J Neoplasm

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Numerous theories and hypotheses are published about the causes of cancer and its hallmarks. Two remarkable principles were established and debated for a long time. The first is the Warburg-effect, which based on mitochondrial dysfunction, connected to the intensive metabolic activity of the malignancy. The other is the Szentgyorgyi's effect which describes the malignancy by changing of the cellular state (α ↔ β) explained by evolutional biology and supported by definitely improved dielectric properties of the malignant tissue from their normal counterpart while these theories have stable explanations, developed many controversies. Both are partial of completely revised time-by-time, showing new insights with new evidence as additions to these old ideas. Our objective is to demonstrate connections between these theories and start new considerations in the actual debates.

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Positron Emission Tomography-Based Molecular Imaging in Human Cancer

Cited by 31 publications

References 19 publications

Hypoxia and cancer

Hypoxia and cancer

Apparent Diffusion Coefficient of Glial Neoplasms: Correlation with Fluorodeoxyglucose–Positron-Emission Tomography and Gadolinium-Enhanced MR Imaging

Connections between Warburg’s and Szentgyorgyi’s Approach about the Causes of Cancer

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