Positron emission tomography and positron emission tomography‐CT evaluation for recurrent papillary thyroid carcinoma: Meta‐analysis and literature review

Miller, M. David; Chen, Qiaolin; Elashoff, David; Abemayor, Elliot; John, Maie St.

doi:10.1002/hed.21492

Cited by 42 publications

(22 citation statements)

References 21 publications

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“…In children, the neck and chest are the most likely sites of persistent disease, and contrast-enhanced imaging of these areas with CT or MRI is favored when US cannot identify disease. 18 FDG-PET/CT has become a commonly used tool in the evaluation of adults with persistent non-iodine-avid thyroid cancer (3,(321)(322)(323)(324)(325)(326) and appears to offer prognostic information that might change clinical management (327)(328)(329)(330). However, there are extremely limited data regarding the use of 18 FDG-PET/CT in children except for a case report (331), isolated pediatric subjects embedded within adult studies, and unpublished data that suggest low sensitivity of 18 FDG-PET/CT to identify residual disease in children that otherwise cannot be identified via cervical US and crosssectional imaging of the neck and chest (personal communication, SGW).…”

Section: Recommendation Rating: C and Recommendation 25(b)mentioning

confidence: 99%

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Francis

Waguespack

Bauer

et al. 2015

Thyroid

973

1,365

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Background: Previous guidelines for the management of thyroid nodules and cancers were geared toward adults. Compared with thyroid neoplasms in adults, however, those in the pediatric population exhibit differences in pathophysiology, clinical presentation, and long-term outcomes. Furthermore, therapy that may be recommended for an adult may not be appropriate for a child who is at low risk for death but at higher risk for long-term harm from overly aggressive treatment. For these reasons, unique guidelines for children and adolescents with thyroid tumors are needed. Methods: A task force commissioned by the American Thyroid Association (ATA) developed a series of clinically relevant questions pertaining to the management of children with thyroid nodules and differentiated thyroid cancer (DTC). Using an extensive literature search, primarily focused on studies that included subjects £ 18 years of age, the task force identified and reviewed relevant articles through April 2014. Recommendations were made based upon scientific evidence and expert opinion and were graded using a modified schema from the United States Preventive Services Task Force. Results: These inaugural guidelines provide recommendations for the evaluation and management of thyroid nodules in children and adolescents, including the role and interpretation of ultrasound, fine-needle aspiration cytology, and the management of benign nodules. Recommendations for the evaluation, treatment, and follow-up of children and adolescents with DTC are outlined and include preoperative staging, surgical management, postoperative staging, the role of radioactive iodine therapy, and goals for thyrotropin suppression. Management algorithms are proposed and separate recommendations for papillary and follicular thyroid cancers are provided.

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Section: Recommendation Rating: C and Recommendation 25(b)mentioning

confidence: 99%

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Francis

Waguespack

Bauer

et al. 2015

Thyroid

973

1,365

View full text Add to dashboard Cite

show abstract

“…However, both imaging procedures have limitation: US cannot image lesions outside the neck and may not detect lymph node micrometastases, and 131 I-WBS has poor accuracy when progressive dedifferentiation of tumour cells has occurred [2]. In the latter cases 18 F-FDG PET/CT has been shown to improve detection and localization of tumour foci [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 97%

Thyroglobulin levels and thyroglobulin doubling time independently predict a positive 18F-FDG PET/CT scan in patients with biochemical recurrence of differentiated thyroid carcinoma

Giovanella

Trimboli

Verburg

et al. 2013

Eur J Nucl Med Mol Imaging

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“…The early detection of iodinenegative DTC lesions is important, because it triggers an adjustment in the treatment strategy: surgical resection, external-beam radiation therapy (EBRT), or multikinase inhibitor therapy will be selected rather than 131 I treatment. 18 F-FDG PET/CT is useful for the detection of recurrent DTC lesions, especially in patients with iodine-negative tumors and elevated serum thyroglobulin levels (6)(7)(8)(9)(10). Furthermore, recent studies showed that 18 F-FDG PET can detect DTC lesions more accurately under thyroid-stimulating hormone (TSH) stimulation than under TSH suppression (11)(12)(13).…”

mentioning

confidence: 99%

Clinical Utility of ¹⁸F-FDG PET/CT Concurrent with ¹³¹I Therapy in Intermediate–to–High-Risk Patients with Differentiated Thyroid Cancer: Dual-Center Experience with 286 Patients

Lee

et al. 2013

J Nucl Med

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Patients with differentiated thyroid carcinoma (DTC) are treated with 131 I therapy after total thyroidectomy or surgical resection of recurrent tumor. However, some recurrent DTC lesions are not iodineavid, which affects further treatment planning. The aim of this study was to evaluate the clinical benefit of 18 F-FDG PET/CT performed concurrently with 131 I therapy in DTC patients with intermediate to high risk. Methods: We retrospectively enrolled 286 DTC patients at 2 Korean medical centers who comprised 2 different patient groups: 28 patients who underwent adjuvant 131 I treatment after curative surgical resection of recurrent tumor and 258 patients with intermediate to high risk who underwent 131 I ablation after total thyroidectomy. 131 I therapy and 18 F-FDG PET/CT scanning were performed on the same day. Administration of L-thyroxine was withheld from all enrollees for 4 wk before 131 I treatment. Results: In 39 patients (14%), 18 F-FDG PET/CT detected additional recurrent or metastatic lesions that were not detected on the posttherapy 131 I scan, and the treatment plan was changed for 30 patients (10%) based on such findings. Among the 28 patients receiving 131 I treatment after resection of recurrent tumor, PET/CT detected additional lesions in 46%, and treatment was changed in 43%. Assessing a subgroup of stage T3-T4N1 patients with tumor size . 2.0 cm, among 258 patients undergoing 131 I ablation after total thyroidectomy, we found that 25% had additional positive PET/CT results, and treatment changed for 17%. In contrast, 8% of stage T3-T4N1 patients with tumor size # 2.0 cm, 6% of stage T1-T2N1 patients, and 3% of stage T3-T4N0 patients had additional positive PET/CT findings. Conclusion: 18 F-FDG PET/CT performed concurrently with 131 I therapy detected additional lesions in 14% of DTC patients and was particularly helpful for detecting additional lesions in patients undergoing 131 I therapy after resection of recurrent tumor or in stage T3-T4N1 patients with tumor size . 2.0 cm.

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Positron emission tomography and positron emission tomography‐CT evaluation for recurrent papillary thyroid carcinoma: Meta‐analysis and literature review

Abstract: PET and PET/CT are useful modalities in surveillance of papillary thyroid carcinoma. To our knowledge, this is the first study to examine papillary thyroid carcinoma independently of other subtypes of well-differentiated thyroid carcinoma.

Cited by 42 publications

References 21 publications

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Thyroglobulin levels and thyroglobulin doubling time independently predict a positive 18F-FDG PET/CT scan in patients with biochemical recurrence of differentiated thyroid carcinoma

Clinical Utility of ¹⁸F-FDG PET/CT Concurrent with ¹³¹I Therapy in Intermediate–to–High-Risk Patients with Differentiated Thyroid Cancer: Dual-Center Experience with 286 Patients

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Positron emission tomography and positron emission tomography‐CT evaluation for recurrent papillary thyroid carcinoma: Meta‐analysis and literature review

Abstract: PET and PET/CT are useful modalities in surveillance of papillary thyroid carcinoma. To our knowledge, this is the first study to examine papillary thyroid carcinoma independently of other subtypes of well-differentiated thyroid carcinoma.

Cited by 42 publications

References 21 publications

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Thyroglobulin levels and thyroglobulin doubling time independently predict a positive 18F-FDG PET/CT scan in patients with biochemical recurrence of differentiated thyroid carcinoma

Clinical Utility of 18F-FDG PET/CT Concurrent with 131I Therapy in Intermediate–to–High-Risk Patients with Differentiated Thyroid Cancer: Dual-Center Experience with 286 Patients

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Clinical Utility of ¹⁸F-FDG PET/CT Concurrent with ¹³¹I Therapy in Intermediate–to–High-Risk Patients with Differentiated Thyroid Cancer: Dual-Center Experience with 286 Patients