Positron emission tomographic scanning in the diagnosis and staging of non–small cell lung cancer 2 cm in size or less

Abstract

Positron emission tomographic scanning has no demonstrable benefit in the diagnosis, staging, or prognosis of patients with tumors of 2 cm or less in size.

Accuracy of PET/CT with FDG in mediastinal lymph node staging of patients with NSCLC

“…Due to this reason and in accordance with other authors we agree on the necessity to confirm PET positive findings with a biopsy [16][17][18][19][20][21][22][23][24]. Therefore, even if PET/CT is more accurate than CT and other preoperative exams in detecting distant and local metastases, both the published literature and our experience underline the continued need for tissue confirmation of a positive PET/CT result.…”

“…Sensitivity, specificity, positive and negative In Table 5 [20][21][22][23][24][25][26][27][28][29], we compared our results with the data showed in the literature analyzing the number of patients, the number of dissected lymph node stations and the sensitivity, specificity, positive and negative predictive values and accuracy, on a per-patient and on a pernodal station analysis (when possible).…”

Long-term survival results of non-small cell lung cancer patients with complete pathological response after neoadjuvant therapy

“…[27][28][29][30][31] In particular, distant recurrences are a serious problem in the postoperative period in patients with complete or near complete response after oncological treatments. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] In the current study, recurrence developed in one patient in the pT 0 tumor group, which was a distant recurrence. Four of the eight recurrences in the pT 1 tumor group were distant and one was both local and distant.…”

“…[32,33] However, due to its limited resolution in detecting a limited number of living tumor cells and relatively low metabolic signal of small tumors, the efficacy of PET decreases. [15][16][17] In addition, its success in defining complete or near complete response is more limited in patients who received oncological treatment before surgery compared to those who did not. [34] Cerfolio et al [35] reported the positive predictive value of PET as 100% and negative predictive value as 67% (one out of three patients was a false negative) after chemotherapy.…”

“…When compared with other conventional methods, positron emission tomography/ computed tomography (PET/CT), which is more likely to produce metabolic information than anatomical information, has been considered to be the most appropriate imaging method; however, its efficacy is limited due to the inadequacy of detecting the small amount of living tumor cells. [15][16][17] In patients who were unresectable or non-operable in the initial evaluation with complete or nearly complete response after chemotherapy and/or radiotherapy, surgical treatment may be performed to particularly avoid local recurrence unless living tumor cells were present.…”