Positivity of dengue, chikungunya, and Zika infections in women in Northeast Brazil post-Zika epidemic

Frota, Cristiane Cunha; Correia, Francisco Gustavo Silveira; Vasconcelos, Lucas Romão Alves; Sousa, Paulo Gleisson Rodrigues de; Ferreira, Marco Levi da Silva; Saraiva, Susy Pereira; Ferreira, Rafael Mota; Romcy, Kalil Andrade Mubarac; Pinheiro, Ronald Feitosa; Oliveira, Roberta Taiane Germano de; Júnior, Francisco Marto Leal Pinheiro; Martins, Adriano Ferreira; Sanhueza-Sanzana, Carlos; Almeida, Rosa Lívia Freitas de; Kendall, Carl; Coêlho, Ivo Castelo Branco; Neto, Roberto da Justa Pires; Aguiar, Ítalo Wesley Oliveira; Kerr, Lígia Regina Franco Sansigolo

doi:10.1080/20477724.2022.2142187

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…In hyperendemic countries for arboviruses such as Colombia, co-infections are often found in patients with febrile syndromes compatible with DENV infection, where arboviral RNA from more than one arbovirus is detected ( 64 , 72 ). Thus, we found co-infections with DENV/ZIKV, DENV/CHIKV, and ZIKV/CHIKV, not to mention co-infections with the three arboviruses.…”

Section: Discussionmentioning

confidence: 99%

High prevalence of dengue, Zika, and chikungunya viruses in blood donors during a dengue outbreak and an endemic period in Colombia

Cáceres Munar,

Urbina,

Ortíz

et al. 2024

Front. Med.

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ObjectiveArboviruses pose a challenge in ensuring the supply of pathogen-free blood components because they are not routinely screened in blood banks, and blood components from infected asymptomatic donors could be transfused. This study aimed to detect and characterize arboviral infections in Colombian blood donors.MethodsIn a cross-sectional study, the prevalence of dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV) viruses and co-infections of blood donors were compared between an epidemic period (November 2019–February 2020, n = 462) and an endemic period (November 2021–August 2022, n = 1,119). Viral RNA from each donor serum was purified, and the viruses were detected using a previously standardized multiplex hemi-nested RT-PCR protocol. Subsequently, donors who tested positive were surveyed 15 days after the detection of the virus to identify clinical characteristics related to the arboviral infection. The prevalences of each virus were presented as percentages and compared between epidemic and endemic periods.ResultsSignificantly higher prevalences were found in the epidemic period compared with the endemic period for DENV (14.5 vs. 1.9%), ZIKV (7.8 vs. 0.3%), CHIKV (8 vs. 3.3%), and co-infections (4.3 vs. 0.2%). The survey response rate of positive donors in the two periods was 83/175 (47%). In total, 57% of the donors surveyed were asymptomatic. Symptomatic donors most frequently reported headache (31%), malaise (13%), arthralgia (10%), and fever/chills (8%).ConclusionThe prevalence observed in epidemic and endemic periods was higher than that reported in other studies in the Americas. The high proportion of asymptomatic cases found, in addition to the mild and nonspecific manifestations among the symptomatic, may limit the effectiveness of the donor selection criteria used to mitigate the risk of transfusion-transmitted arboviruses.

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Section: Discussionmentioning

confidence: 99%

High prevalence of dengue, Zika, and chikungunya viruses in blood donors during a dengue outbreak and an endemic period in Colombia

Cáceres Munar,

Urbina,

Ortíz

et al. 2024

Front. Med.

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Global Prevalence of Zika and Chikungunya Coinfection: A Systematic Review and Meta-Analysis

Ahmed,

Sultana,

Kundu

et al. 2024

Diseases

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Zika virus (ZIKV) and chikungunya virus (CHIKV) are arthropod-borne viruses with significant pathogenicity, posing a substantial health and economic burden on a global scale. Moreover, ZIKV-CHIKV coinfection imposes additional therapeutic challenges as there is no specific treatment for ZIKV or CHIKV infection. While a growing number of studies have documented the ZIKV-CHIKV coinfection, there is currently a lack of conclusive reports on this coinfection. Therefore, we performed a systematic review and meta-analysis to determine the true statistics of ZIKV-CHIKV coinfection in the global human population. Relevant studies were searched for in PubMed, Scopus, and Google Scholar without limitation in terms of language or publication date. A total of 33 studies containing 41,460 participants were included in this meta-analysis. The study protocol was registered with PROSPERO under the registration number CRD42020176409. The pooled prevalence and confidence intervals of ZIKV-CHIKV coinfection were computed using a random-effects model. The study estimated a combined global prevalence rate of 1.0% [95% CI: 0.7–1.2] for the occurrence of ZIKV-CHIKV coinfection. The region of North America (Mexico, Haiti, and Nicaragua) and the country of Haiti demonstrated maximum prevalence rates of 2.8% [95% CI: 1.5–4.1] and 3.5% [95% CI: 0.2–6.8], respectively. Moreover, the prevalence of coinfection was found to be higher in the paediatric group (2.1% [95% CI: 0.0–4.2]) in comparison with the adult group (0.7% [95% CI: 0.2–1.1]). These findings suggest that the occurrence of ZIKV-CHIKV coinfection varies geographically and by age group. The results of this meta-analysis will guide future investigations seeking to understand the underlying reasons for these variations and the causes of coinfection and to develop targeted prevention and control strategies.

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Positivity of dengue, chikungunya, and Zika infections in women in Northeast Brazil post-Zika epidemic

Cited by 2 publications

References 22 publications

High prevalence of dengue, Zika, and chikungunya viruses in blood donors during a dengue outbreak and an endemic period in Colombia

High prevalence of dengue, Zika, and chikungunya viruses in blood donors during a dengue outbreak and an endemic period in Colombia

Global Prevalence of Zika and Chikungunya Coinfection: A Systematic Review and Meta-Analysis

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