Positivity and prevalence of human papillomavirus among a large population of women in southeastern China

Abstract

Objective To formulate strategies for prevention of cervical cancer, we investigated the prevalence of human papillomavirus (HPV) infection and the age-specific distribution among female participants in southeastern China. Methods From January 2016 to July 2018, 36,871 women from Meizhou People’s Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University were enrolled in this prospective study. HPV genotypes were detected using Luminex technology. Results HPV infection was observed in 18.34% of the participants, and 79.98% were infected with high-risk HPVs. The five most prevalent genotypes were HPV52 (18.18%), HPV16 (16.06%), HPV58 (11.37%), HPV53 (8.82%), and HPV39 (6.42%). The 9-valent HPV vaccine efficiently reduced the HPV infection rate by more than 10%, which is twofold the rate of other vaccines. Most HPV infections were observed in women age 40 to 49 years, and those age 30 to 59 years accounted for 79.62% of positive patients. Conclusion Our findings regarding HPV genotypes and the age-specific distribution of HPV infection in the study area will contribute to the development of cervical cancer screening programs and vaccine strategies.

Prevalence characteristics of cervical human papillomavirus (HPV) infection in the Zhoupu District, Shanghai City, China

“…In the 59,541 outpatient women, the overall prevalence of HPV was 17.92% and the HR-HPV prevalence was 15.56%. Compared with similar studies in China, the prevalence in our study was higher than that in Xinjiang (14.02%) [11], Urumqi (16.74%) [12], Zhejiang (17.6%) [13], and Nanjing KingMed Diagnostics (17.7%) [14], but lower than that in Meizhou (18.34%) [15], Wuhan (18.6%) [13], Beijing (20.16%) [4], Guangdong (21.06%) [16] Shandong (28.4%) [17], and three cities (Xuzhou, Nanjing and Suzhou) of Jiangsu Province (26.92%) [18]. Different HPV prevalence rates may be a combination of different economic levels, cultural diversity, geographic locations, and survey periods.…”

“…Analysis of HPV prevalence indicates that the most common HR-HPV genotypes in outpatient women are HPV 52,16,58,53 and 39. These are the same common genotypes as Meizhou [15]. This is similar to other studies conducted in China.…”

Current Updates on Cancer-Causing Types of Human Papillomaviruses (HPVs) in East, Southeast, and South Asia

“…The overall HPV-positive detection rate in normal women ranges from 7.2% (Malaysia) to 41.7% (Hong Kong). The HPV genotypes commonly detected in these regions are HPV16, 18, 52, 58, 31, 33, 35, 39, 45, 51, 56, 59, 68, 6, 11, 42, 43, and 81 [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ].…”

“…As China is a geographically wide country, we collated studies on the distribution of HPV genotypes according to traditional geographical regions: East, South, Southwest, Northwest, Central, North, and Northeast China. In general, the most prevalent hrHPV genotypes detected in normal uterine cervixes were found to be HPV16, 52, and 58, followed by HPV18, 31,33,35,39,45,51,56,59, and 68 [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][38][39][40][41][42][43][44][45]63]. The most commonly detected low-risk Human Papillomavirus (lrHPV) types were found to be HPV6, 11, and 81.…”

“…The most commonly detected low-risk Human Papillomavirus (lrHPV) types were found to be HPV6, 11, and 81. Based on age groups, HPV detection rate was shown to be the highest among women of age >55, followed by 30-55 years old, and <30 years old [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][38][39][40][41][42][43][44][45]63].…”