Positively reinforcing effects of the neurokinin substance P in the basal forebrain: Mediation by its C-terminal sequence

Hasenöhrl, Rüdiger U.; Gerhardt, P.; Huston, Joseph P.

doi:10.1016/0014-4886(92)90063-v

Cited by 38 publications

(10 citation statements)

References 57 publications

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“…2) (Groenewegen and Russchen, 1984; Marksteiner et al, 1992) and at least in part terminate on ventral pallidum cholinergic neurons potentially bearing NK1 receptors (Zaborszky and Cullinan, 1992). SP injected directly into this area induces place preference behavior (Hasenohrl et al, 1992; Hasenohrl et al, 1998a; Hasenohrl et al, 1998b; Nikolaus et al, 1999). …”

Section: Motivation and Reward Pathwaysmentioning

confidence: 99%

“…For example, it had been previously shown that NK1 receptor activation by itself is able to produce conditioned place preference (Hasenohrl et al, 1992; Hasenohrl et al, 1998a; Hasenohrl et al, 1998b; Nikolaus et al, 1999). The effects of SP on major neurotransmitter systems involved in addiction-related behaviors including dopamine, serotonin, norepinephrine and acetylcholine had also been known (reviewed by (Goodman, 2008)).…”

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confidence: 99%

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Neuronal pathways linking substance P to drug addiction and stress

Commons

2010

Brain Research

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Accumulating evidence suggests that the neuropeptide Substance P (SP), and it’s principal receptor neurokinin 1 (NK1), play a specific role in the behavioral response to opioids and stress that may help to initiate and maintain addictive behavior. In animal models, the NK1 receptor is required for opioids to produce their rewarding and motivational effects. SP neurotransmission is also implicated in the behavioral response to stress and in the process of drug sensitization, potentially contributing to vulnerability to addiction or relapse. However, SP neurotransmission only plays a minor role in opioid-mediated antinociception and the development of opioid tolerance. Moreover, the effects of SP on addiction-related behavior are selective for opioids and evidence supporting a role in the response to cocaine or psychostimulants is less compelling. This review will summarize the effects of SP neurotransmission on opioid-dependent behaviors and correlate them with potential contributing neural pathways. Specifically, SP neurotransmission within components of the basal forebrain particularly the nucleus accumbens and ventral pallidum as well as actions within the ascending serotonin system will be emphasized. In addition, cellular or network level interactions between opioids and SP signaling that may underlie the specificity of their relationship will be reviewed.

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Section: Motivation and Reward Pathwaysmentioning

confidence: 99%

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confidence: 99%

Neuronal pathways linking substance P to drug addiction and stress

Commons

2010

Brain Research

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“…One finding of this experiment was that although both SP and vehicle injection led to an increase in cortical ACh, this increase was higher in the vehicle group than in the SP group in both hemispheres, but reached significance only in the ipsilateral hemisphere. Furthermore, NBM injection of 1 ng SP is known to have rewarding effects on the basis of place-preference procedures (Holzhä uer-Oitzl et al, 1988;Hasenöhrl et al, 1992;Boix et al, 1995). There are several possible explanations for this inhibitory effect of SP: 1) Previous studies have shown that frontal cortex ACh release is activated by novelty and conditioned fear (Acquas et al, 1996) and by sensory stimulation which produced freezing (Inglis and Fibiger, 1995), suggesting that ACh release is associated with behavioral responses to "stressful" stimuli.…”

Section: Discussion "Freely Moving" Preparationmentioning

confidence: 99%

“…Third, several in vitro as well as in-vivo studies have shown SP to have neurotrophic and neuroprotective effects (Yankner et al, 1990;Kowall et al, 1991;Mattioli et al, 1992;Sprick et al, 1996), which might be relevant to Alzheimer and Parkinson diseases (Barker, 1996). Fourth, the local administration of SP into the NBM has memory-promoting, reinforcing, and anxiolytic-like effects, with a dose of 1 ng of SP being the most effective (Kafetzopoulos et al, 1986;Holzhä uer-Oitzl et al, 1988;Hasenöhrl et al, 1992Hasenöhrl et al, , 1998a. In search of the possible physiological mechanisms that may underlie these behavioral effects, we have shown that SP injections into the NBM area can increase dopamine release in the NAcc, a brain area that is known to play a critical role in mechanisms of reward.…”

Section: Introductionmentioning

confidence: 99%

Differential modulation of frontal cortex acetylcholine by injection of substance P into the nucleus basalis magnocellularis region in the freely-moving vs. the anesthetized preparation

Silva

Hasenhrl

Tomaz

et al. 2000

Synapse

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In vivo microdialysis was used to assess the effects of unilateral substance P (SP) injection into the nucleus basalis magnocellularis on extracellular levels of acetylcholine (ACh) in the frontal cortex, either in freely moving or urethane‐anesthetized rats. The results show that the neurochemical effects of SP are critically dependent on the choice of the experimental preparation: In the freely‐moving rat, the injection procedure led to behavioral and concurrent bilateral cholinergic activation in the frontal cortex. This cholinergic activation was ipsilaterally reduced by intrabasalis injection of SP (1 ng), indicating that the peptide exerted an inhibitory influence on the neurochemical effect exerted by handling, intracranial needle insertion, and vehicle injection. In the anesthetized preparation, SP had a biphasic dose‐dependent action on cortical ACh: a short‐lasting ipsilateral increase immediately after injection (especially with 1 ng), and a delayed bilateral increase after more than 2 h (10, 100 ng). The procedure of inserting the injection needle moderately increased cortical ACh levels. Methodologically, these data are discussed with respect to the importance of using anesthetized vs. freely moving rats and the effects of intraparenchymal injections. Synapse 38:243–253, 2000. © 2000 Wiley‐Liss, Inc.

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“…In addition, SP has reinforcing effects when injected systemically (Oitzl et al 1990) or into brain regions, where memory promoting effects were observed, i.e. the basal forebrain (Holzh/iuer- Oitzl et al 1988;Hasen6hrl et al 1992;Huston and Oitzl 1989, for review).…”

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confidence: 98%

Mnemogenic effects of injecting RA-octil, a CE-inhibitor derivate, systemically or into the basal forebrain

Gerhardt

Hasenöhrl

Hock³

et al. 1993

Psychopharmacology

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The aim of this study was to investigate the effects of systemically or intracerebrally administered RA-octil, a derivative of the angiotensin converting enzyme (CE)-inhibitor ramipril, on memory and reinforcement and to compare its effectiveness with that of the neurokinin substance P (SP). In the first experiment systemic post-trial application of RA-octil and SP in the rat enhanced habituation, a learning task which does not require motivational treatments. Unlike SP, injection of RA-octil did not have reinforcing effects as measured with a conditioned place preference task. In the second experiment, a facilitation of inhibitory avoidance learning was obtained by injection of RA-octil or SP unilaterally into the basal forebrain immediately after the learning trial. In contrast, a 5 h delayed injection of RA-octil had no effects on learning. The results demonstrate memory-enhancing effects of RA-octil after systemic application as well as after injection into the basal forebrain. Furthermore, the mnemogenic effects of SP after central and peripheral administration were confirmed. Since RA-octil, although being structurally closely related to CE-inhibitors, does not affect plasma CE, yet exhibits mnemogenic effects, it is possible that "cognition-enhancing" actions of CE-inhibitors are dissociable from their action within the renin-angiotensin system.

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Positively reinforcing effects of the neurokinin substance P in the basal forebrain: Mediation by its C-terminal sequence

Cited by 38 publications

References 57 publications

Neuronal pathways linking substance P to drug addiction and stress

Neuronal pathways linking substance P to drug addiction and stress

Differential modulation of frontal cortex acetylcholine by injection of substance P into the nucleus basalis magnocellularis region in the freely-moving vs. the anesthetized preparation

Mnemogenic effects of injecting RA-octil, a CE-inhibitor derivate, systemically or into the basal forebrain

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