Positive space acquiring asymmetric membranes for guiding alveolar bone regeneration under infectious conditions

Wang, Bing; Qin, Chuanlan; Liu, Yiming; Zhang, Yu‐Qiu; Feng, Chengmin; Mi, Fanglin; Zhu, Hong

doi:10.1016/j.bioadv.2022.213252

Cited by 4 publications

(6 citation statements)

References 24 publications

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“…This indicates that the PDPA membrane has a distinct effect on guiding regeneration of bone, possibly caused by its fibrosis inhibition and the positive space acquiring effect on bone augmentation for that PDPA membrane for PDPA membrane did not have excellent proliferation promotive effect on osteogenesis related cells as shown in Figure 1(a). 16,22 BP + PDPA membrane + antimicrobial membrane group had the best retentive effect, but the regenerative speed of bone in this group was slower than that of other therapeutic groups. Although the purpose of this design was to make the GBR membrane exert antimicrobial and space acquiring effects at the same time, there was no external infectious source in this calvarial defect model, and thus the antimicrobial function on bone regeneration could not be exerted.…”

Section: Bone Regeneration-guided Effect Of Gbr Materials In the Rat ...mentioning

confidence: 78%

“…13–15 Furthermore, the flexibility of electrospun membranes endows them with excellent encapsulated capacities, making them suitable for application in conjunction with bone substitute filling therapy in guiding alveolar bone regeneration before implantation. 16…”

Section: Introductionmentioning

confidence: 99%

“…[13][14][15] Furthermore, the flexibility of electrospun membranes endows them with excellent encapsulated capacities, making them suitable for application in conjunction with bone substitute filling therapy in guiding alveolar bone regeneration before implantation. 16 However, there are shortcomings in the application of electrospun membranes in guiding alveolar bone regeneration. These shortcomings include poor mechanical properties that cannot maintain bone regeneration spaces, and lack of biofunctions that cannot fully adapt to complex physiological environments, especially with pathogenic bacteria in the oral cavity, such as under periodontitis conditions.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of positive space acquiring membrane and antimicrobial membrane combined with granular bone substitute implantation in guiding oral bone regeneration

Qin,

Ren,

Liu

et al. 2023

J Biomater Appl

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Augmentation of the alveolar bone is important before oral implantation. For large bone defects, it becomes necessary to apply guided bone regeneration (GBR) materials, accompanied by filling defect sites with autologous or allogeneic bone, or bone substitutes such as acellular bone powder. In this study, we tested a granular bone substitute and GBR membrane combination therapy in treating MC3T3-E1 and L929 cells in vitro and rat calvarial and alveolar defects in vivo. The recovery conditions of bone defects were monitored by micro-CT, and 3D reconstruction of the CT images was applied to evaluate the bone augmentation semi-quantitatively. Test GBR materials could support the proliferation of MC3T3-E1 cells, poly (p-dioxanone-co-L-phenylalanine) (PDPA)-based membrane could induce apoptosis of L929 cells. Among GBR membranes applied groups, the regeneration condition of defected calvarial defects of PDPA based membrane applied group was the best and this may be caused by its excellent positive space acquiring effect. However, in a complex bacteriogenic environment, the oral bone regeneration-guided efficacy of the PDPA membrane decreased in the post-repair stage with the aggravation of infections. By contrast, the antimicrobial membrane combined with the PDPA membrane exhibited continually increasing GBR efficacy at the later stage of repair owing to its multifunctional properties, which are infection-inhibiting and positive space acquiring. Therefore, multifunctional GBR membranes are preferable for GBR in complex oral environments, and further research should be conducted to determine their efficacy in other models.

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Section: Bone Regeneration-guided Effect Of Gbr Materials In the Rat ...mentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy of positive space acquiring membrane and antimicrobial membrane combined with granular bone substitute implantation in guiding oral bone regeneration

Qin,

Ren,

Liu

et al. 2023

J Biomater Appl

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“…PDO sutures start to lose their strength within the first few days after surgery and can be completely absorbed by the body within 4–6 months. PDO is also known for its good handling properties and minimal tissue reaction . Additionally, PDO sutures are nonantigenic, which means that they are unlikely to cause an immune response and have minimal tissue reaction, which reduces the risk of infection and wound healing complications .…”

Section: Synthetic Resorbable Membranesmentioning

confidence: 99%

“…PDO is also known for its good handling properties and minimal tissue reaction . Additionally, PDO sutures are nonantigenic, which means that they are unlikely to cause an immune response and have minimal tissue reaction, which reduces the risk of infection and wound healing complications . PDO has a good balance of mechanical and degradation properties, meaning it has good strength while also breaking down at a suitable rate, making it a promising option for GBR .…”

Section: Synthetic Resorbable Membranesmentioning

confidence: 99%

Resorbable Membranes for Guided Bone Regeneration: Critical Features, Potentials, and Limitations

et al. 2023

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Lack of horizontal and vertical bone at the site of an implant can lead to significant clinical problems that need to be addressed before implant treatment can take place. Guided bone regeneration (GBR) is a commonly used surgical procedure that employs a barrier membrane to encourage the growth of new bone tissue in areas where bone has been lost due to injury or disease. It is a promising approach to achieve desired repair in bone tissue and is widely accepted and used in approximately 40% of patients with bone defects. In this Review, we provide a comprehensive examination of recent advances in resorbable membranes for GBR including natural materials such as chitosan, collagen, silk fibroin, along with synthetic materials such as polyglycolic acid (PGA), polycaprolactone (PCL), polyethylene glycol (PEG), and their copolymers. In addition, the properties of these materials including foreign body reaction, mechanical stability, antibacterial property, and growth factor delivery performance will be compared and discussed. Finally, future directions for resorbable membrane development and potential clinical applications will be highlighted.

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A Janus, robust, biodegradable bacterial cellulose/Ti3C2Tx MXene bilayer membranes for guided bone regeneration

Zhou,

Zhao,

Zha

et al. 2024

Biomaterials Advances

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Positive space acquiring asymmetric membranes for guiding alveolar bone regeneration under infectious conditions

Cited by 4 publications

References 24 publications

Efficacy of positive space acquiring membrane and antimicrobial membrane combined with granular bone substitute implantation in guiding oral bone regeneration

Efficacy of positive space acquiring membrane and antimicrobial membrane combined with granular bone substitute implantation in guiding oral bone regeneration

Resorbable Membranes for Guided Bone Regeneration: Critical Features, Potentials, and Limitations

A Janus, robust, biodegradable bacterial cellulose/Ti3C2Tx MXene bilayer membranes for guided bone regeneration

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