Key words Solutions, boundary value problems, lower and upper solutions, Nagumo condition, fixed point theorem MSC (2010) 34B15, 34B18We consider the boundary value problem u, u , . . . , u (n −1) = 0, t ∈ (0, 1),where n ≥ 2 and m ≥ 1 are integers, tj ∈ [0, 1] for j = 1, . . . , m, and f and gi , i = 0, . . . , n − 1, are continuous. We obtain sufficient conditions for the existence of a solution of the above problem based on the existence of lower and upper solutions. Explicit conditions are also found for the existence of a solution of the problem. The differential equation has dependence on all lower order derivatives of the unknown function, and the boundary conditions cover many multi-point boundary conditions studied in the literature. Schauder's fixed point theorem and appropriate Nagumo conditions are employed in the analysis. Examples are given to illustrate the results.