Generalized monotone method together with coupled lower and upper solutions yield monotone sequences which converge uniformly and monotonically to coupled minimal and maximal solutions of the nonlinear problem under consideration. In this work, we have developed generalized monotone method for sequential Caputo fractional boundary value problem with mixed boundary conditions which are in terms of Caputo fractional derivative. For that purpose, we have obtained a representation form for the corresponding linear Caputo sequential boundary value problem in terms of the Green's function. In addition, we have obtained a linear comparison result for the linear sequential differential inequalities with linear mixed boundary conditions. The comparison result is useful in proving the monotonicity of the iterates as well as the uniqueness of the solution of the nonlinear sequential boundary value problem. Our method yields the integer results as a special case. Some numerical examples for the linear sequential Caputo fractional boundary value problems have also been presented.