We establish the existence of a positive solution for semilinear elliptic equation in exterior domains −∆u + V (x)u = f (u), in Ω ⊆ R N (P V) where N ≥ 2, Ω is an open subset of R N and R N \ Ω is bounded and not empty but there is no restriction on its size, nor any symmetry assumption. The nonlinear term f is a non homogeneous, asymptotically linear or superlinear function at infinity. Moreover, the potential V is a positive function, not necessarily symmetric. The existence of a solution is established in situations where this problem does not have a ground state.