Positive QuantiFERON test and the severity of COVID-19 disease: A prospective study

Gupta, Ajay Kumar; Sural, Sumit; Gupta, Ayush; Rousa, Shashank; Koner, Bidhan Chandra; Bhalotra, Anju; Chawla, Rohit

doi:10.1016/j.ijtb.2020.12.013

Cited by 12 publications

(33 citation statements)

References 23 publications

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“…A "positive IGRA" is indicative of active or prior Mtb infection; an "indeterminate IGRA" can stem from either an insufficient response to the positive control, or too high a background response to the negative control. Consistent with our present animal model study, Gupta et al observed that a cohort of 20 asymptomatic COVID patients were more likely to have a positive IGRA than 20 severely ill COVID patients [31], suggesting those with prior TB exposure are less likely to develop symptoms following CoV2 infection. Equally interesting are elevated rates of indeterminate IGRA in hospitalized COVID patients, due to too low IFNγ levels in the positive control blood collection tubes [32,33].…”

Section: Plos Pathogenssupporting

confidence: 91%

Mice infected with Mycobacterium tuberculosis are resistant to acute disease caused by secondary infection with SARS-CoV-2

Mejia¹,

Gloag²,

Li³

et al. 2022

PLoS Pathog

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Mycobacterium tuberculosis (Mtb) and SARS-CoV-2 (CoV2) are the leading causes of death due to infectious disease. Although Mtb and CoV2 both cause serious and sometimes fatal respiratory infections, the effect of Mtb infection and its associated immune response on secondary infection with CoV2 is unknown. To address this question we applied two mouse models of COVID19, using mice which were chronically infected with Mtb. In both model systems, Mtb-infected mice were resistant to the pathological consequences of secondary CoV2 infection, and CoV2 infection did not affect Mtb burdens. Single cell RNA sequencing of coinfected and monoinfected lungs demonstrated the resistance of Mtb-infected mice is associated with expansion of T and B cell subsets upon viral challenge. Collectively, these data demonstrate that Mtb infection conditions the lung environment in a manner that is not conducive to CoV2 survival.

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Section: Plos Pathogenssupporting

confidence: 91%

Mice infected with Mycobacterium tuberculosis are resistant to acute disease caused by secondary infection with SARS-CoV-2

Mejia¹,

Gloag²,

Li³

et al. 2022

PLoS Pathog

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“…Several studies have shown an increased number of indeterminate QFT assay results in patients hospitalized because of SARS-CoV-2 [16,17,[21][22][23][24][25]. Patients with an indeterminate response are those with compromised immune responses and inadequate ability to be activated by a mitogen control [21,24].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, indeterminate results of the QFT assay could predict mortality in COVID-19 patients [21]. In a recent work on a limited number of subjects, it has been shown that patients with severe COVID-19 had a decreased IFN-γ production after mitogen stimulation compared to asymptomatic COVID-19 patients and healthy donors, in an endemic area for tuberculosis [25].…”

Section: Introductionmentioning

confidence: 99%

In Patients with Severe COVID-19, the Profound Decrease in the Peripheral Blood T-Cell Subsets Is Correlated with an Increase of QuantiFERON-TB Gold Plus Indeterminate Rates and Reflecting a Reduced Interferon-Gamma Production

Imeneo

Alessio

Lorenzo

et al. 2022

Life

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Increased rates of indeterminate QuantiFERON-TB Gold Plus Assay (QFT-Plus) were demonstrated in patients hospitalized with Coronavirus Disease (COVID)-19. We aimed to define the prevalence and characteristics of hospitalized COVID-19 patients with indeterminate QFT-Plus. A retrospective study was performed including hospitalized COVID-19 patients, stratified in survivors and non-survivors, non-severe and severe according to the maximal oxygen supply required. Statistical analysis was performed using JASP ver0.14.1 and GraphPad Prism ver8.2.1. A total of 420 patients were included, median age: 65 years, males: 66.4%. The QFT-Plus was indeterminate in 22.1% of patients. Increased rate of indeterminate QFT-Plus was found in non-survivors (p = 0.013) and in severe COVID-19 patients (p < 0.001). Considering the Mitogen-Nil condition of the QFT-Plus, an impaired production of interferon-gamma (IFN-γ) was found in non-survivors (p < 0.001) and in severe COVID-19 patients (p < 0.001). A positive correlation between IFN-γ levels in the Mitogen-Nil condition and the absolute counts of CD3+ (p < 0.001), CD4+ (p < 0.001), and CD8+ (p < 0.001) T-lymphocytes was found. At the multivariable analysis, CD3+ T-cell absolute counts and CD4/CD8 ratio were confirmed as independent predictors of indeterminate results at the QFT-Plus. Our study confirmed the increased rate of indeterminate QFT-Plus in COVID-19 patients, mainly depending on the peripheral blood T-lymphocyte depletion found in the most severe cases.

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“…Additionally, the detection of IgM against the receptor-binding domain (RBD) of S protein by the rapid test kit was found to be less effective, but IgG detection was reported as an effective diagnostic tool for SARS-CoV-2 infection [6]. Furthermore, research conducted by the biochemistry department, MAMC also came up with a conclusion that the exposed population in an endemic area of tuberculosis and typhoid is likely to withstand COVID -19 better with a reduced mortality [7].…”

Section: Significant Role Of the Biochemistry Departmentmentioning

confidence: 99%

The Challenges During the COVID-19 Waves in India – from an Intensivists Experience

Wadhawan¹,

Husain²,

SC³

et al. 2023

Act Scie Micro

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The unprecedented rise in cases during the second wave of COVID-19 in India unembellished life-threatening consequences as demand-supply gaps were increased many folds. It led to a significant constraint on the existing medical supplies. Additionally, an unprecedented rise in mortality was observed in the unvaccinated young and middle-aged population. An evidence-based observation and experience including the challenges faced by intensivists as to why the second wave was more dangerous than the first one, could help in identifying the potential areas to target with future control strategies.

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Positive QuantiFERON test and the severity of COVID-19 disease: A prospective study

Cited by 12 publications

References 23 publications

Mice infected with Mycobacterium tuberculosis are resistant to acute disease caused by secondary infection with SARS-CoV-2

Mice infected with Mycobacterium tuberculosis are resistant to acute disease caused by secondary infection with SARS-CoV-2

In Patients with Severe COVID-19, the Profound Decrease in the Peripheral Blood T-Cell Subsets Is Correlated with an Increase of QuantiFERON-TB Gold Plus Indeterminate Rates and Reflecting a Reduced Interferon-Gamma Production

The Challenges During the COVID-19 Waves in India – from an Intensivists Experience

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