Positive Q fever skin test after vaccination

Parker, Neil R

doi:10.5694/j.1326-5377.2004.tb05780.x

Cited by 2 publications

(2 citation statements)

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“…Of the five cases (including our case) for which clinical history was available, three had a temporal association between influenza vaccination and Q fever vaccination, followed by the development of the non‐necrotising granuloma. The indurated lesion at the separate Q fever skin‐test site on the volar forearm, found in two other patients 5 as well as ours, supports the notion of a systemic immune reaction rather than simply a local reaction at the vaccination site. The Naranjo score in this case was 7, indicating a “probable” adverse drug reaction.…”

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confidence: 88%

“…Development of non‐necrotising granulomas following Q fever vaccination is uncommon, with only six cases previously described 3 . ‐ 5 To explore the possibility of a causal association between influenza vaccination, Q fever vaccination, and development of a granuloma, we traced four of these six patients with Q fever granuloma by contacting the authors of the previous reports. One patient had been vaccinated against influenza 2 months before the time of Q fever vaccination, and another had influenza vaccination afterwards (as in our case).…”

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confidence: 99%

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A rare granulomatous reaction to Q fever vaccination following influenza vaccination

Burnett

2010

Medical Journal of Australia

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Section: Boxsupporting

confidence: 88%

Section: Boxmentioning

confidence: 99%

A rare granulomatous reaction to Q fever vaccination following influenza vaccination

Burnett

2010

Medical Journal of Australia

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Control strategies for Q fever based on results of pre‐vaccination screening in Victoria, 1988 to 2001

Greig

Patel

Clements

et al. 2005

Australian and New Zealand Journal of Public Health

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Objective: Data from Q fever prevaccination screening were analysed to determine the level of agreement between the two tests of immunity and between disease or vaccination history and immunity, trends in proportion of participants immune to Q fever, and the annual risk of infection. Method: Data from nearly 10,000 screening episodes between July 1988 and June 2001 on Victorian workers at high risk were assessed. Results: Most participants were male (86%) and employed in Victorian abattoirs (81%). Agreement between results of tests for immunity was ‘fair’ (k=0.52). Selfreported history of vaccination or infection was a poor predictor of immunity. The proportion of positive blood and skin tests increased with years of exposure to animals/meat, but decreased over the 13‐year period with shorter exposures. Hence the percentage requiring vaccination increased from 50% in 1998 to 90% in 2001. The average annual risk of infection among abattoir workers was 45.0 per 1,000 (95% CI 42.3–47.6), and 62.6 per 1,000 (95% CI 57.5–67.7) over the first 10 years of exposure. Conclusions: This is the first Australian study to estimate the annual risk of Q fever infection in abattoir workers. The study confirmed previous findings of poor agreement between screening tests and predictive value of history of vaccination/exposure. Up to 90% of new entrants in high‐risk workplaces will be susceptible to Q fever and require vaccination. Implications: Systematic post‐marketing surveillance is needed to monitor adverse events to the vaccine, duration of protection and possible reasons for vaccine failures.

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Positive Q fever skin test after vaccination

Cited by 2 publications

References 1 publication

A rare granulomatous reaction to Q fever vaccination following influenza vaccination

A rare granulomatous reaction to Q fever vaccination following influenza vaccination

Control strategies for Q fever based on results of pre‐vaccination screening in Victoria, 1988 to 2001

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