Positive predictive values of sonographic features of solid thyroid nodule

Hong, Yoo Jin; Son, Eun Ju; Kim, Min Jung; Kwak, Jin Young; Hong, Soon Won; Chang, Hang Seok

doi:10.1016/j.clinimag.2008.10.034

Cited by 72 publications

(75 citation statements)

References 23 publications

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“…Howarth suggested a malignant risk of less than 5% for TIRADS 3,5%to10% for TIRADS4b and greater than 80% for TIRADS5.Our findings were within this range suggested by Hogarth [8], Russ et al [17] and Moifo et al [16]. Another study conducted by Hong et al [18] concluded that the three sonographic features that are meaningful findings in the diagnosis of thyroid malignancy were the presence of microcacifications,marked hypogenecity and a taller than wide shape. In a multimeter Korean retrospective study, the ultrasound features that were statistically significant for malignancy were hypoechogenicity, marked hypoechogenicity,nonparametric orientation, microlobulated or spiculated margin, an ill defined margins and the presence of microcalcifications.…”

Section: Discussion:-supporting

confidence: 82%

Correlation of Tirads [Thyroid Imaging Reporting and Data System] and Histopathological Findings in Evaluation of Thyroid Nodules.

Bhatnagar¹,

Mohi²,

Kaur³

et al. 2017

IJAR

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Purpose: Ultrasound [US] is an excellent noninvasive modality to evaluate thyroid nodules.Aim of our study was to characterize the thyroid nodules according to grey scale sonographic features into high suspicious ,probably benign, benign aspects and normal thyroid using TIRADS scoring system and to characterize the thyroid nodule according to the sonographic features into a specific TIRADS stage and correlate the results with the histopathological examination findings wherever possible. Material And Methods: The prospective study was carried out on 60 patients referred to Department of Radiodiagnosis, Rajindra Hospital,Patiala. All the patients were subjected to detailed history taking,clinical examination and routine laboratory investigations.All thyroid nodules were characterized according to the internal component[solid, mixed or cystic], the margins, echogenicity [hyperechoic, Isoechoic,hypoechoic, marked hypoehoic], evidence of calcification [microcalcification if less than 3mm and macrocalcification if more than 3mm with acoustic shadowing]and the shape[taller than wide if greater in anteroposterior dimension than in its transverse dimension and wider than tall]. Using the Modified Russ Classification, each nodule was classified into TIRADS categories [1,2,3,4A,4B and 5] based on ultrasound features.The patients were referred to Department of Pathology, Government Medical College Patiala and FNAC was done. The US findings were correlated with FNAC and data was analyzed statistically. Results: Based on various ultrasound characteristics of thyroid nodules,TIRADS score was given to each thyroid nodule and then FNAC was done.The results of histopathology were correlated with ultrasound features and statistical analysis was done calculating sensitivity, specificity,positive predictive value and negative predictive value for each feature.The sensitivity and specificity for Irregular contours were 44.4% and 94.12%,for taller than wide were 22.22% and 100%,for microcalcification were33.3.3% and 94.12%,for marked hypoechogenicity was 78 and 70.89% and for solid consistency were89 and 70.5%.The risk of malignancy was found to increase from TIRADS3 to TIRADS5 in this study. All the cases [100%] of TIRADS 5 turned out to be malignant on histopathology. Conclusion: Radiologists should be aware of usefulness of specific ultrasound features of thyroid nodules like Irregular contours, tallerCorresponding Author:-Simmi Bhatnagar.

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Section: Discussion:-supporting

confidence: 82%

Correlation of Tirads [Thyroid Imaging Reporting and Data System] and Histopathological Findings in Evaluation of Thyroid Nodules.

Bhatnagar¹,

Mohi²,

Kaur³

et al. 2017

IJAR

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“…Similarly, in a long term study from Boston, Yassa et al found no difference in cancer rates in nodules between 1cm and greater than 3cm 31 . Similar results have been produced from other parts of the world 32,33 . A study from Seoul looking at sub cm nodules actually found a higher rate of malignancy in the smaller nodules 34 .…”

Section: Sizesupporting

confidence: 87%

“…In fact, many authors looking at newer ultrasound features only review solid nodules and exclude cystic lesions altogether 32,33 . In an older paper from 2001, Koike et al from Japan showed that 81.8% of all malignant nodules were completely solid 37 and in 2007, a Korean study of 1036 patients demonstrated that 98.4% of papillary cancers and 82.6% of follicular cancers were solid 38 .…”

Section: 1solid/cysticmentioning

confidence: 99%

Pre-operative diagnosis of thyroid cancer: Clinical, radiological and pathological correlation

Cairncross¹,

Panieri²

2013

S Afr J Surg

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“…Of these, 235 studies were retrieved for further investigation, and 41 studies (14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54) met the final selection criteria and were included in the analysis. All 41 studies were observational studies published in peer-reviewed journals between 1989 and 2012.…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

DIAGNOSIS IN ENDOCRINOLOGY: Quantification of cancer risk of each clinical and ultrasonographic suspicious feature of thyroid nodules: a systematic review and meta-analysis

Campanella

Ianni

Rota

et al. 2014

European Journal of Endocrinology

106

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Objective: In order to quantify the risk of malignancy of clinical and ultrasonographic features of thyroid nodules (TNs), we did a systematic review and meta-analysis of published studies. Methods: We did a literature search in MEDLINE for studies published from 1st January 1989 until 31st December 2012. Studies were considered eligible if they investigated the association between at least one clinical/ultrasonographic feature and the risk of malignancy, did not have exclusion criteria for the detected nodules, had histologically confirmed the diagnoses of malignancy, and had a univariable analysis available. Two reviewers independently extracted data on study characteristics and outcomes. Results: The meta-analysis included 41 studies, for a total of 29 678 TN. A higher risk of malignancy expressed in odds ratio (OR) was found for the following: nodule height greater than width (OR: 10.15), absent halo sign (OR: 7.14), microcalcifications (OR: 6.76), irregular margins (OR: 6.12), hypoechogenicity (OR: 5.07), solid nodule structure (OR: 4.69), intranodular vascularization (OR: 3.76), family history of thyroid carcinoma (OR: 2.29), nodule size R4 cm (OR: 1.63), single nodule (OR: 1.43), history of head/neck irradiation (OR: 1.29), and male gender (OR: 1.22). Interestingly, meta-regression analysis showed a higher risk of malignancy for hypoechoic nodules in iodine-sufficient than in iodine-deficient geographical areas. Conclusions: The current meta-analysis verified and weighed out each suspicious clinical and ultrasonographic TN feature. The highest risk was found for nodule height greater than width, absent halo sign, and microcalcifications for ultrasonographic features and family history of thyroid carcinoma for clinical features. A meta-analysis-derived grading system of TN malignancy risk, validated on a large prospective cohort, could be a useful tool in TN diagnostic work-up.

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Positive predictive values of sonographic features of solid thyroid nodule

Cited by 72 publications

References 23 publications

Correlation of Tirads [Thyroid Imaging Reporting and Data System] and Histopathological Findings in Evaluation of Thyroid Nodules.

Correlation of Tirads [Thyroid Imaging Reporting and Data System] and Histopathological Findings in Evaluation of Thyroid Nodules.

Pre-operative diagnosis of thyroid cancer: Clinical, radiological and pathological correlation

DIAGNOSIS IN ENDOCRINOLOGY: Quantification of cancer risk of each clinical and ultrasonographic suspicious feature of thyroid nodules: a systematic review and meta-analysis

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