Positive postprandial glycaemic and appetite-related effects of wheat breads enriched with either α-cyclodextrin or hydroxytyrosol/α-cyclodextrin inclusion complex

The effect of alpha-cyclodextrin on postprandial glucose excursions, a systematic meta analysis Alpha-cyclodextrin and Blood Glucose

“…The comparisons based on the four subsequent studies (Gentilcore 2011; Sugahara 2016; Bär 2020; Binou 2022a; b), excluding the two studies serving high-fat meals (Jarosz 2013; Lytle 2018) , are consistent with the doseresponse relationship initially observed (Buckley 2006) :…”

“…In the initial (Buckley 2006) and a second study (Binou 2022a; b) , 5g were significant (at P=0.03 and P=0.06, respectively, combined P=0.013 (Fisher 1948) , well below the FCPT cut-off of 0.0175).…”

“…Glucose: there was significant efficacy from at least two studies [14, 22, 23]. Insulin: The reduction in one study [4] was not significant ( P = 0.09).…”

“…Two additional publications were identified. One had glucose profiles only as a secondary outcome (Lytle 2018) , the other was published only after the FDA had made its decision (Binou 2022a; b) .…”

“…5 g / 50 g: In the initial [14] and a second study [22,23], 5 g were significant (at P = 0.03 and P = 0.06, respectively, combined P = 0.013 [8], well below the FCPT cut-off of 0.0175). One of the "10 g" studies (actually: 5 g per 50 g sucrose) is excluded from this meta-analysis because the participants were older (68-76 yr) and consumed a sucrose drink [4], rather than a highcarb meal.…”