Positive patch test in vancomycin allergy

Drug patch testing in systemic cutaneous drug allergy

“…In a CADR due to vancomycin, prick tests as well as intradermal tests done with glycopeptide antibiotics remained negative even on delayed readings while drug patch tests were positive with specific results (20 negative controls) (Bernedo et al, 2001). This case emphasizes that delayed reactions to IDT are not sufficient to investigate a CADR due to delayed hypersensitivity to drugs, but that drug patch tests have also to be performed as they can be positive while IDT remain negative.…”

“…Miscellaneous drugs have been reported as yielding CADR with positive drug patch tests (Barbaud et al, 1998b;Barbaud, 2003): acyclovir and valaciclovir (Lammintausta et al, 2001;Vernassiere et al, 2003), allylisopropylacetylurea in a FDE (Sakakibara et al, 2001), captopril (Barbaud et al, 1998b), cefcapene pivoxil (Kawada et al, 2001), celecoxib (Britschgi et al, 2001;Verbeiren et al, 2002), clobazam (Machet et al, 1992), codeine diluted at 1 and 5% in petrolatum (two negative controls) (Estrada et al, 2001), co-trimoxazole (Klein et al, 1995), cyamemazine (Barbaud et al, 1998b), diazepam (Felix and Comaish, 1974), diclofenac (Jonker and Bruynzeel, 2003;Romano et al, 1994), enoxoparin (Barbaud et al, 1998b), estrogens (Gonçalo et al, 1999), fluoroquinolones (Barbaud et al, 1998b;Rodriguez-Morales et al, 2001), fusafungine (Barbaud et al, 1998b), isoniazide at 50% in petrolatum (10 negative controls) (Rebello et al, 2001), Lamisil ® (Barbaud et al, 1998b), meprobamate (Barbaud et al, 2001a), metamizole at 1 and 10% in petrolatum (Gonzalo-Garijo et al, 2001;Quinones Estevez, 2001), mexiletine hydrochloride diluted at 10 and 20% in petrolatum (Sasaki et al, 2001), nystatin at 10% in petrolatum (10 negative controls) (Barranco et al, 2001), paracetamol (acetaminophen) (Mashiah and Brenner, 2003) and vancomycin at 0.005% in water (Bernedo et al, 2001).…”

A Case of Hypersensitivity Syndrome to Both Vancomycin and Teicoplanin

“…Only one report showed positive patch tests for both vancomycin and teicoplanin in a patient with hypersensitivity to vancomycin. However, teicoplanin was not used and its potential hypersensitivity was not determined (12). Our case clinically suggested a possible cross-reactivity between these glycopeptide antibiotics in the hypersensitivity syndrome.…”

Patch testing and sensitization to multiple drugs

“…DRESS elicited by rifampicin and vancomycin was recently reported (23), but prick tests remained negative in that patient. Positive patch test reactions to vancomycin have been described (24), but > 40 drugs have been associated with DRESS (25). Our patient also developed positive reactions to metronidazole.…”