Positive Modulation Effect of 8-Week Consumption ofKaempferia parvifloraon Health-Related Physical Fitness and Oxidative Status in Healthy Elderly Volunteers

Abstract

Health-related physical fitness declines as the age advances. Oxidative stress is reported to contribute the crucial role on this phenomenon. This condition is also enhanced by antioxidant. Therefore, we aimed to determine the effect of Kaempferia parviflora, a plant reputed for antifatigue, longevity promotion, and antioxidant effects, on health-related quality physical fitness and oxidative status of the healthy elderly volunteers. Total 45 subjects had been randomized to receive placebo or K. parviflora extract at doses of 25 or 90 mg once daily for 8 weeks. They were determined baseline data of physical performance using 30 sec chair stand test, hand grip test, 6 min walk test, and tandem test. Serum oxidative stress markers including malondialdehde (MDA) level and the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) were also assayed. All assessments were performed every 4 weeks throughout the 8-week study period. The results showed that K. parviflora increased performance in 30-second chair stand test and 6 min walk test together with the increased all scavenger enzymes activities and the decreased MDA level. Therefore, K. parviflora can enhance physical fitness partly via the decreased oxidative stress. In conclusion, K. parviflora is the potential health supplement for elderly. However, further study is required.

EVALUATION OF THAI STYLE STRETCHING EXERCISE ON €œRUESI DUD TON” ON PHYSICAL HEALTH AND OXIDATIVE STRESS IN HEALTHY VOLUNTEER

“…MDA was estimated by determining the accumulation of Thiobarbituric Acid Reactive Substances (TBARS) (Wattanathorn et al, 2012) in the nerve homogenate whereas the activities of Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GSH-Px) were determined by recording the ability to inhibit cytochrome C, the rate of decrease in H 2 O 2 and the amount of reduced Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidized per minute respectively (Jittiwat et al, 2009). …”

Enhancement of physical fitness by black ginger extract rich in polymethoxyflavones: a double-blind randomized crossover trial

“…A clinical report demonstrated that KPE effectively increased physical fitness in elderly subjects aged 60 or more [37]. Therefore, KPE may have more prominent effects on physical fitness and fatigue in elderly people and individuals lacking an exercise habit, among whom muscular metabolism has declined.…”

“…anti-inflammatory, antioxidant [18][19][20][21], anticancer [22,23], muscular metabolismenhancing [24], anti-photoaging [25], phosphodiesterase (PDE)5 inhibitory [26], anti-cardiovascular disease [27], and viral protease inhibitory [28] activities). A large number of studies have investigated the bioactivities of black ginger extract (KPE), which is rich in PMFs [24,[29][30][31][32][33][34][35][36][37]. We also reported that PMFs in KPE improved muscular metabolism through AMP-activated protein kinase (AMPK) activation in myocytes [24].…”

“…We also reported that PMFs in KPE improved muscular metabolism through AMP-activated protein kinase (AMPK) activation in myocytes [24]. Furthermore, clinical trials have been conducted on the effects of KPE physical performance in athletes and elderly subjects [36,37].…”

“…The hand grip strength test and 30-second chair stand test were performed according to the methods described in a previous study [37]. In the 5-m tandem walking test, the time to walk 5 m with tandem steps was measured.…”