Positive immunological reaction of gut cells from orally immunized animals demonstrated by passive cutaneous anaphylaxis

Levanon, Y; Raettig, H; Rossetini, S. M. O.

doi:10.1007/bf02153798

Cited by 6 publications

(1 citation statement)

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“…On the other hand, Felsenfeld et al (5) have shown that in vervet monkeys orally immunized with V/br/o choleras, antibody-producing cells were more numerous in the mesenteric lymph nodes than in the spleen. Using the method of passive cutaneous anaphylaxis, Levanon et al (39) obtained evidence that suspensions of intestinal cells from guinea pigs orally immunized with heat-killed Salmonella typkiraurium were able to sensitize nonimmunized animals to the antigen.…”

Section: Role Of the Intestinal Mucosa In The Antibodymentioning

confidence: 99%

ANTIBODIES OF THE IgA TYPE IN INTESTINAL PLASMA CELLS OF GERMFREE MICE AFTER ORAL OR PARENTERAL IMMUNIZATION WITH FERRITIN

Crabbé

Nash

Bazin

et al. 1969

The Journal of Experimental Medicine

190

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In adult germfree C3H mice immunized with horse spleen ferritin, either subcutaneously or intraperitoneally, plasma cells containing specific antibodies were found in lymph nodes and spleen and, in smaller numbers, also in the lamina propria of the intestine. In extraintestinal sites, these antiferritin-containing plasma cells were mainly of the IgM class after a single stimulation, and of the IgG1 class after repeated stimulation. In the intestine, all the anti-ferritin-containing cells appeared to be of the IgA class. Circulating antibodies, after repeated stimulation, were for the major part IgG1 and IgG2. In germfree mice given ferritin in their drinking water, antiferritin-containing cells were abundant in the intestinal mucosa, much less numerous in the mesenteric lymph nodes, and extremely scarce in other lymphoid tissues. All these cells, whatever their location, appeared to belong exclusively to the IgA class. Similarly, all the circulating antibody in these animals was found to be IgA. These findings illustrate the role of the gut as a site of antibody synthesis, as well as its selective commitment to the production of antibodies of the IgA class.

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Section: Role Of the Intestinal Mucosa In The Antibodymentioning

confidence: 99%