Positive Immunolabelling for Feline Infectious Peritonitis in an African Lion (Panthera leo) with Bilateral Panuveitis

Mwase, M.; Shimada, Kazumi; Mumba, Chisoni; Yabe, John; Squarre, David; Madarame, Hiroo

doi:10.1016/j.jcpa.2014.12.006

Cited by 12 publications

(10 citation statements)

References 9 publications

(11 reference statements)

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“…Besides its diagnostic use, IHC has also been applied to detect FCoV antigen in macrophages in unusual tissues or non-domestic felids. As such, FCoV antigen was detected in the skin of two cats with atypical skin lesions caused by FIP [120,121], in the penile tissue of a male cat [122], in different tissues obtained from a mountain lion [123] and in ocular tissues from a lion [124].…”

Section: Detection Of Fcov Antigen In Macrophages By Immunostainingmentioning

confidence: 99%

Diagnosis of Feline Infectious Peritonitis: A Review of the Current Literature

Felten

Hartmann

2019

Viruses

115

164

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Feline infectious peritonitis (FIP) is a fatal disease that poses several challenges for veterinarians: clinical signs and laboratory changes are non-specific, and there are two pathotypes of the etiologic agent feline coronavirus (FCoV), sometimes referred to as feline enteric coronavirus (FECV) and feline infectious peritonitis virus (FIPV) that vary fundamentally in their virulence, but are indistinguishable by a number of diagnostic methods. This review focuses on all important steps every veterinary practitioner has to deal with and new diagnostic tests that can be considered when encountering a cat with suspected FIP with the aim to establish a definitive diagnosis. It gives an overview on all available direct and indirect diagnostic tests and their sensitivity and specificity reported in the literature in different sample material. By providing summarized data for sensitivity and specificity of each diagnostic test and each sample material, which can easily be accessed in tables, this review can help to facilitate the interpretation of different diagnostic tests and raise awareness of their advantages and limitations. Additionally, diagnostic trees depict recommended diagnostic steps that should be performed in cats suspected of having FIP based on their clinical signs or clinicopathologic abnormalities. These steps can easily be followed in clinical practice.

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Section: Detection Of Fcov Antigen In Macrophages By Immunostainingmentioning

confidence: 99%

Diagnosis of Feline Infectious Peritonitis: A Review of the Current Literature

Felten

Hartmann

2019

Viruses

115

164

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“…60 Bilateral panuveitis due to FCoV has been reported in lions and sphinx cats, and macrophages with FCoV were identified via immunohistochemistry. 4,5 Murine hepatitis coronavirus (MHV) is also a betacoronavirus and has been found to be the etiology of eye disease in experimental mouse models. Following intraocular inoculation of the virus, early retinal vasculitis (1-7 days) can ensue and is later followed by retinal degeneration (10-14 days).…”

Section: Ophthalmic Findings In Other Human Coronaviruses and Animal mentioning

confidence: 99%

“…Other members of the Coronaviridae family have been shown to cause ophthalmic disease, including retinal pathology. In animals, feline coronavirus (FCoV) can cause uveitis, scleritis, and retinitis in cats, 4,5 and murine hepatitis coronavirus (MHV) can cause retinal vasculitis and degeneration in mice. [6][7][8][9] Human coronavirus NL63 (HCoV-NL63) can cause conjunctivitis in humans, and the closely related SARS-CoV has been found in the tears of infected patients.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 and the Eye: Implications for the Retina Specialist From Human Coronavirus Outbreaks and Animal Models

Kennedy

Shantha

et al. 2020

Journal of VitreoRetinal Diseases

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Purpose: The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has escalated rapidly since December 2019. Understanding the ophthalmic manifestations in patients and animal models of the novel coronavirus may have implications for disease surveillance. Recognition of the potential for viral transmission through tear film has ramifications for patients, physicians, and the public. Methods: Information from relevant published journal articles was surveyed using a computerized PubMed search and public health websites. We summarize knowledge of ophthalmic manifestations of SARS-CoV-2 infection in patients and animal models, risk-mitigation measures for patients and providers, and implications for retina specialists. Results: SARS-CoV-2 is efficiently transmitted among humans, and although the clinical course is mild in most infected patients, severe complications including pneumonia, acute respiratory distress syndrome, and death can ensue, most often in elderly patients and individuals with comorbidities. Conjunctivitis occurs in a minority of patients with COVID-19, and SARS-CoV-2 RNA has been identified primarily with conjunctivitis. Uveitis has been observed in animal models of coronavirus infection, and cotton-wool spots have been reported recently. Conclusions: SARS-CoV-2 and other coronaviruses have been rarely associated with conjunctivitis. Identification of SARS-CoV and SARS-CoV-2 RNA in the tear film of patients and its highly efficient transmission via respiratory aerosols supports eye protection, mask, and gloves as part of infection prevention and control recommendations for retina specialists. Disease surveillance during the COVID-19 pandemic may also include ongoing evaluation for uveitis and retinal disease given prior findings from animal models and a recent report of retinal manifestations.

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“…It has the morphology, structure, and biological characteristics of the Coronavirus genus. Within the species Feline infectious peritonitis virus, two types have been identified: the feline infectious peritonitis virus itself (VPIF) and CEF feline enteric coronavirus) which produce the dominant peritonitis symptoms in the cat of enteritis [1][2][3][4][5].…”

mentioning

confidence: 99%