Positive Health Benefits of Saponins from Edible Legumes: Phytochemistry and Pharmacology

Kareem, Ozaifa; Ali, Tabasum; Dar, Lateef Ahmad; Mir, Suhail Ahmad; Rashid, Rumaisa; Nazli, Naqshab; Gulzar, Tawseef; Bader, Ghulam Nabi

doi:10.1007/978-981-16-4959-2_8

Cited by 10 publications

(7 citation statements)

References 102 publications

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“…Natural compounds known as saponins can be found in a variety of plants, especially in legume seeds and roots, herbs, vegetables, and fruits [ 49 ]. Their name is derived from their ability to form soapy lathers when mixed with water.…”

Section: Discussionmentioning

confidence: 99%

Saponin-Derived Silver Nanoparticles from Phoenix dactylifera (Ajwa Dates) Exhibit Broad-Spectrum Bioactivities Combating Bacterial Infections

Adnan,

Siddiqui,

Ashraf

et al. 2023

Antibiotics

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The emergence of antibiotic resistance poses a serious threat to humankind, emphasizing the need for alternative antimicrobial agents. This study focuses on investigating the antibacterial, antibiofilm, and anti-quorum-sensing (anti-QS) activities of saponin-derived silver nanoparticles (AgNPs-S) obtained from Ajwa dates (Phoenix dactylifera L.). The design and synthesis of these novel nanoparticles were explored in the context of developing alternative strategies to combat bacterial infections. The Ajwa date saponin extract was used as a reducing and stabilizing agent to synthesize AgNPs-S, which was characterized using various analytical techniques, including UV–Vis spectroscopy, Fourier transform infrared (FTIR) spectroscopy, and transmission electron microscopy (TEM). The biosynthesized AgNPs-S exhibited potent antibacterial activity against both Gram-positive and Gram-negative bacteria due to their capability to disrupt bacterial cell membranes and the leakage of nucleic acid and protein contents. The AgNPs-S effectively inhibited biofilm formation and quorum-sensing (QS) activity by interfering with QS signaling molecules, which play a pivotal role in bacterial virulence and pathogenicity. Furthermore, the AgNPs-S demonstrated significant antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals and cytotoxicity against small lung cancer cells (A549 cells). Overall, the findings of the present study provide valuable insights into the potential use of these nanoparticles as alternative therapeutic agents for the design and development of novel antibiotics. Further investigations are warranted to elucidate the possible mechanism involved and safety concerns when it is used in vivo, paving the way for future therapeutic applications in combating bacterial infections and overcoming antibiotic resistance.

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Section: Discussionmentioning

confidence: 99%

Saponin-Derived Silver Nanoparticles from Phoenix dactylifera (Ajwa Dates) Exhibit Broad-Spectrum Bioactivities Combating Bacterial Infections

Adnan,

Siddiqui,

Ashraf

et al. 2023

Antibiotics

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“…Saponins froth in aqueous solutions and have a characteristic bitter flavor, which can affect the taste of food when present in large quantities 60 . Saponins cause hemolysis, vomiting, and nausea, and prevents cholesterol absorption, leading to hypercholesterolemia 61 .…”

Section: Phytochemical Composition the Five Extracts Of P Ostreatusmentioning

confidence: 99%

Comparative antioxidant activity and phytochemical content of five extracts of Pleurotus ostreatus (oyster mushroom)

Effiong,

Umeokwochi,

Afolabi

et al. 2024

Sci Rep

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Reactive oxygen species reacts with numerous molecules in the body system causing oxidative damage, which requires antioxidants to ameliorate. Pleurotus ostreatus, a highly nutritious edible mushroom, has been reported to be rich in bioactive compounds. This study evaluated the comparative antioxidant activity and phytochemical contents of five extracts of P. ostreatus: aqueous (AE), chloroform (CE), ethanol (EE), methanol (ME) and n-hexane (HE). The phytochemical composition and antioxidant activity of the extracts were determined using standard in-vitro antioxidant assay methods. Results showed that the extracts contained alkaloids, tannins, saponins, flavonoids, terpenoids, phenolics, cardiac glycosides, carbohydrates, anthrocyanins, and betacyanins in varied amounts. CE had the highest flavonoid content (104.83 ± 29.46 mg/100 g); AE gave the highest phenol content of 24.14 ± 0.02 mg/100 g; tannin was highest in EE (25.12 ± 0.06 mg/100 g); HE had highest amounts of alkaloids (187.60 ± 0.28 mg/100 g) and saponins (0.16 ± 0.00 mg/100 g). Antioxidant analyses revealed that CE had the best hydroxyl radical activity of 250% at 100 µg/ml and ferric cyanide reducing power of 8495 µg/ml; ME gave the maximum DPPH activity (87.67%) and hydrogen peroxide scavenging activity (65.58%) at 500 µg/ml; EE had the highest nitric oxide radical inhibition of 65.81% at 500 µg/ml and ascorbate peroxidase activity of 1.60 (iU/l). AE had the best total antioxidant capacity (5.27 µg/ml GAE at 500 µg/ml) and ferrous iron chelating activity (99.23% at 100 µg/ml) while HE gave the highest guaiacol peroxidase activity of 0.20(iU/l). The comparative phytochemical and antioxidant characteristics (IC50) of the extracts followed the order: CE > AE > EE > ME > HE. Overall, chloroform was the best extraction solvent for P. ostreatus. The high content of phenolic compounds, flavonoids, and alkaloids in P. ostreatus makes it a rich source of antioxidants and potential candidate for the development of new therapies for a variety of oxidative stress-related disorders.

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“…Saponins reduce lipids in the blood, the risk of cancer and the body's response to insulin. A diet high in saponin can stop tooth decay and platelet clumping, treat hypercalciuria in people and cure acute lead poisoning 54 .…”

Section: Quantitative Analysis Of Secondary Metabolitesmentioning

confidence: 99%

Phytochemical Analysis of Amorphophallus paeoniifolius (Dennst.) Nicolson and Its Standardisation by HPLC and HPTLC

Bhuvaneswari

Sivasubramanian

2023

Orient. J. Chem

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Elephant foot yams (Amorphophallus paeoniifolius (Denst.) Nicolson) are an important part of the diet in many parts of Asia. This study aims to analyse the physiochemical, phytochemicals, and in vitro antioxidant properties of different alcoholic and aqueous extracts. HPTLC and HPCL profile of ethanolic extract tubers of A. paeoniifolius was also investigated. Important secondary metabolites were detected through physicochemical analysis and phytochemical screening. In a laboratory, the antioxidant activity of A. paeoniifolius extracts was evaluated using standard free radical scavenging assays. HPLC testing showed that Gallic Acid, Quercetin, and Rutin could be used to standardise A. paeoniifolius. The study's results showed that it would give information that could be used to identify and verify this medicinal plant correctly and may help prevent its adulteration. The extracts of A. paeoniifolius have the potential to be a powerful antioxidant that can get rid of free radicals. The parameters for characterising A. paeoniifolius described in this paper could be used as a quality control standard for this plant.

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Positive Health Benefits of Saponins from Edible Legumes: Phytochemistry and Pharmacology

Cited by 10 publications

References 102 publications

Saponin-Derived Silver Nanoparticles from Phoenix dactylifera (Ajwa Dates) Exhibit Broad-Spectrum Bioactivities Combating Bacterial Infections

Saponin-Derived Silver Nanoparticles from Phoenix dactylifera (Ajwa Dates) Exhibit Broad-Spectrum Bioactivities Combating Bacterial Infections

Comparative antioxidant activity and phytochemical content of five extracts of Pleurotus ostreatus (oyster mushroom)

Phytochemical Analysis of Amorphophallus paeoniifolius (Dennst.) Nicolson and Its Standardisation by HPLC and HPTLC

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