Positive Findings on an Early Autoantibody Panel in Sjögren's Syndrome Often Predate Positive Findings on Classic Tests: Comment on the Article by Theander et al

Lichtbroun, Alan S.

doi:10.1002/art.39705

Cited by 1 publication

(1 citation statement)

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“…In some diseases, autoantibodies develop before clinical manifestations of autoimmune disease appear; examples include Sjögren’s syndrome (SS), autoimmune hepatitis, multiple sclerosis, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and primary biliary cirrhosis. The roles of autoantibodies in the pathology of these diseases are different; indeed, these antibodies can have diverse effects against the same antigen depending on the target epitope [ 2 , 7 , 8 , 9 , 10 , 11 ]. Some autoantibodies in the sera of autoimmune disease patients exert various functions; for example, they act as pathogenic molecules that mimic hormone stimulation of receptors, block neural transmission by binding to receptors, affect signaling pathways, lyse cells, and induce inflammation at the site of autoantibody binding [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Functional Roles and Applications of Immunoglobulins in Neurodegenerative Disease

Sim

Park

2020

IJMS

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Natural autoantibodies, immunoglobulins (Igs) that target self-proteins, are common in the plasma of healthy individuals; some of the autoantibodies play pathogenic roles in systemic or tissue-specific autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. Recently, the field of autoantibody-associated diseases has expanded to encompass neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), with related studies examining the functions of Igs in the central nervous system (CNS). Recent evidence suggests that Igs have various effects in the CNS; these effects are associated with the prevention of neurodegeneration, as well as induction. Here, we summarize the functional roles of Igs with respect to neurodegenerative disease (AD and PD), focusing on the target antigens and effector cell types. In addition, we review the current knowledge about the roles of these antibodies as diagnostic markers and immunotherapies.

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