Positive expression of KIF20A indicates poor prognosis of glioma patients

Abstract

Glioma patients have a poor overall survival; however, patients can show distinct clinical outcomes due to the high heterogeneity of the tumor, which may be indicated by certain clinicobiological parameters. Kinesin family member 20A (KIF20A), which participates in cytokinesis and intracellular transportation, has been recently reported to be upregulated in pancreatic cancer, breast cancer, and bladder cancer. In the current study, we investigated the expression of KIF20A in gliomas and its significance in predicting the prognosis after surgery. We found that KIF20A positive expression in glioma tissues correlated significantly with Ki67 protein expression and advanced World Health Organization grade. Univariate and multivariate analysis revealed that KIF20A can act as an independent prognostic factor for predicting the overall survival of glioma patients. Moreover, we demonstrated that KIF20A can positively regulate the expression of Ki67 in glioma cell lines. Correspondingly, overexpression of KIF20A can promote cell proliferation and invasion, whereas knockdown of KIF20A can inhibit cell viability and invasion capacity. In vitro study also showed that under the treatment of plumbagin, an anticancer drug, KIF20A expression decreased in a dose-dependent manner. In addition, the overexpression of KIF20A can also increase the drug resistance toward plumbagin, which provided the possibility that KIF20A may contribute to the chemotherapy resistance of gliomas.

Overexpression of KIF20A confers malignant phenotype of lung adenocarcinoma by promoting cell proliferation and inhibiting apoptosis

“…In addition, univariate as well as multivariate Cox regression analyses demonstrated that KIF20A expression can be considered as an independent prognostic factor of OS in patients with LUAD. Our findings were highly consistent with previous studies about the prognostic impact of KIF20A in other cancers …”

“…Using chi‐square test, we analyzed the correlation between KIF20A expression and Ki‐67 in LUAD tissues. Our result showed that KIF20A expression in LUAD was highly positively correlated with Ki‐67 level, bearing similarities with observations from Duan et al who reported that the expression of KIF20A was relevant to Ki67 expression in gliomas. The Pearson's correlation analysis of the two factors in LUAD tissues from TCGA dataset was consistent with our findings, implying that KIF20A could be an indicator of tumor proliferation as well as Ki‐67.…”

“…In 2005, for the first time, the oncogenic properties of KIF20A was confirmed in pancreatic cancer, and downregulating KIF20A could significantly decrease tumor cell proliferation . Then its carcinogenic traits were reported in various cancers, such as nasopharyngeal carcinoma, hepatocarcinoma,pancreatic cancer,melanoma, and glioma . Accordingly, KIF20A was considered a tumor‐associated antigen (TAA), and its overexpression correlated with the oncogenesis and prognosis of cancers.…”

“…6 Then its carcinogenic traits were reported in various cancers, such as nasopharyngeal carcinoma, 7 hepatocarcinoma 8 ,pancreatic cancer 6,9 ,melanoma, 10 and glioma. 11,12 Accordingly, KIF20A was considered a tumor-associated antigen (TAA), and its overexpression correlated with the oncogenesis and prognosis of cancers. Cancer cells overexpressed KIF20A can be recognized by hosts to initiate immune response, thereby KIF20-derived peptides could be used as a novel immunotherapy agent.…”

Novel miRNA-mRNA interactions conserved in essential cancer pathways

“…Moreover CDC20, described as prognostic in colon64 and breast65, has been identified as relevant in KICH and LUAD in our study. Finally NCAPG and KIF20A genes of prognostic value in gliomas6667 were found relevant here in LUAD. We also identified a few novel associations in lung tumours (LUAD), for instance CENPK has not previously been associated with this cancer type, even though the gene had already been associated to ovarian cancer68.…”