“…In the past three decades, a multitude of physicians and scientists dedicated themselves to identify the best PEEP levels for patients under surgeries (Beiderlinden et al, 2003, Berendes et al, 1996, Bensenor et al, 2007, as well as patients with variable diseases, such as ALI or ARDS (Badet et al, 2009, Huh et al, 2009, morbid obesity (Bohm et al, 2009, Erlandsson et al, 2006, chronic obstructive pulmonary disease (COPD) (Glerant et al, 2005, Mancebo et al, 2000, brain-injury (Shapiro andMarshall, 1978, Huynh et al, 2002), including infants (Greenough et al, 1992, Dimitriou et al, 1999. Although different terminologies and endpoints for optimizing PEEP were used (Villar, 2005), most of the approaches tried to obtain the best oxygenation while minimizing VILI as outcome.…”