Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: A meta-analysis

Karssemeijer, Esther G.A.; Aaronson, Justine A.; Bossers, Willem; Smits, Tara; Rikkert, Marcel G M Olde; Kessels, Roy P. C.

doi:10.1016/j.arr.2017.09.003

Cited by 355 publications

(293 citation statements)

References 55 publications

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“…However, there is a gap in the literature regarding the relationship between exercise, cognition, and brain network connectivity, which the current study attempts to address. Meta-analysis, cross-sectional studies, and randomized controlled trials confirm aerobic activity improves neurological function and cognitive outcomes for aging populations and is negatively correlated with subjective cognitive impairment (SCI), MCI, and Alzheimer's disease [36][37][38][39][40]. In the current study, patients noted their physical activity on a daily protocol tracking form.…”

Section: Physical Exercisementioning

confidence: 91%

Feasibility of a Functional Medicine Approach to Slowing Clinical Cognitive Decline in Patients over Age 55: A Multiple Case Study Report

James¹,

Moore²,

Carpenter³

et al. 2019

obm icm

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Background: The current study examined a multifaceted anti-neuroinflammatory intervention that included physical exercise, mental exercise, grain-free/sugar-free diet, anti-inflammatory nutritional supplements, sleep optimization, and stress management within the context of a functional medicine practice for five patients with varying levels of cognitive impairment. Methods: In a prospective chart review, we examined impact measures including assessment of (1) cognitive skills, (2) brain connectivity, and (3) daily functioning. Results: Three of the five patients were no longer classified as cognitively impaired, while a fourth patient improved from moderately-to-severely impaired to mildly impaired. Patients

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Section: Physical Exercisementioning

confidence: 91%

Feasibility of a Functional Medicine Approach to Slowing Clinical Cognitive Decline in Patients over Age 55: A Multiple Case Study Report

James¹,

Moore²,

Carpenter³

et al. 2019

obm icm

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“…The role of physical activity (PA) is gaining attention in this group of people because of the evidence that shows the positive effects of it on healthy older adults, such as the prevention of some diseases including type 2 diabetes, strokes, hypertension and some types of cancer [9]. Furthermore, there are also bene cial effects of PA on unhealthy elders with dementia [10], depression [11], mild cognitive impairment (MCI) [12,13], and Alzheimer's [14] or Parkinson's disease [15].…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: A Systematic Review of the Literature Regarding Physical, Cognitive and Emotional Outcomes in Older Adults Practitioners of Physical Exercise

Araque-Martínez¹,

Artés-Rodríguez²,

Casimiro-Andújar³

et al. 2020

Preprint

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Background: This systematic review provides an overview about those papers with a specific physical exercise intervention aimed to improve physical, cognitive and/or emotional outcomes in healthy older people aged 60 or over. Studies with no intervention whose sample were active healthy older adults were also included.Methods: An exhaustive literature search was done through two databases, including studies from January 2000 to July 2020. Results: Of the 2006 identified records, 66 met the inclusion criteria and were selected. Results from the review showed a wide variety of older adults and lengths of the interventions, from five weeks (the shortest one) to five years. Aerobic exercise, either isolated or combined with strength performance, was also the most common type of exercise recognized in this systematic review.Conclusions: Findings also suggest that the number of studies with all, physical, cognitive and emotional outcomes have been increasing during recent years in healthy older adults.

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“…In a 12-week intervention for people with MCI involving diet, omega-3 supplements, physical activity, cognitive stimulation, neurofeedback and meditation, 84% significantly improved cognitive function and 53% showed hippocampal growth [26]. The multimodal approach may thus be effective for improving cognitive function [27] and for maintaining or improving cognitive health [28], for persons with mild cognitive impairment (MCI) or dementia [29]. However, randomly assigned interventions to treat memory complaints with a multidomain intervention and polyunsaturated fatty acids, either alone or in combination, revealed no significant effects on cognitive decline over 3 years [30], which may support arguments for a personalised approach.…”

Section: Dementia Prevention -Current Evidence On Multimodal Non-pharmentioning

confidence: 99%

Personalised Medicine for Dementia: Collaborative Research of Multimodal Non-pharmacological Treatment with the UK National Health Service (NHS)

Chalfont¹,

Simpson²,

Davies³

et al. 2019

obm geriatr

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The dominant narrative around dementia argues that progression cannot be halted or reversed. However, evidence on multimodal non-pharmacological treatments formulated around a 'personalised medicine' approach challenges this view. This paper reviews the current evidence for dementia prevention utilising such treatments and explains the logic of applying personalised medicine. The functional medicine treatment approach to 'root cause' analysis is presented as currently practiced with patients experiencing cognitive decline. We report six case reports including in-depth practitioner evaluations, recommendations and follow-ups. We cover the various presentations of memory and concentration problems and the screening process with advanced functional testing. The case reports appear in a table, followed by 11 key points, insights and findings. To our knowledge, this is the first paper reporting practitioner case reports documenting improvements in symptoms of memory

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Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: A meta-analysis

Cited by 355 publications

References 55 publications

Feasibility of a Functional Medicine Approach to Slowing Clinical Cognitive Decline in Patients over Age 55: A Multiple Case Study Report

Feasibility of a Functional Medicine Approach to Slowing Clinical Cognitive Decline in Patients over Age 55: A Multiple Case Study Report

WITHDRAWN: A Systematic Review of the Literature Regarding Physical, Cognitive and Emotional Outcomes in Older Adults Practitioners of Physical Exercise

Personalised Medicine for Dementia: Collaborative Research of Multimodal Non-pharmacological Treatment with the UK National Health Service (NHS)

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