Positive culture results and longer duration between onset and microincision vitrectomy have adverse effects on post-cataract surgery endophthalmitis outcome

Kung, Wei-Hsun; Lai, Chun-Ting; Lin, Chun-Ju; Bair, Henry; Chen, Huansheng; Lin, Jane-Ming

doi:10.1016/j.jfma.2019.06.010

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…In the current analysis, initial BCVA (logMAR) and time from onset to initial IVAs showed independent positive correlations with the final BCVA (logMAR), which indicates that the severity of the condition at baseline, as well as untimely treatment, are risk factors for poor vision outcomes. These findings were also in accordance with several previous reports [2,8,17,20]. A better initial BCVA indicates the possibility of a shorter disease course, less damage to intraocular tissues, and a greater chance of a good visual outcome.…”

Section: Discussionsupporting

confidence: 92%

Management and Prognosis of Acute Post-Cataract Surgery Endophthalmitis: A 10-Year Retrospective Analysis in Eastern China

Zhang,

Chen,

et al. 2023

Antibiotics

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Acute post-cataract surgery endophthalmitis (APSE) is a serious vision-threatening complication of cataract surgery. Analysis of the management and prognosis in cases of APSE may provide better guidance for future treatment. Fifty-six patients (56 eyes) diagnosed with APSE between 2013 and 2022 were retrospectively reviewed. The incidence of APSE rate was 0.020% (95% CI: 0.011–0.029%). Intraocular cultures were positive in 18 (32.1%) cases, with 21 organisms isolated. Coagulase-negative staphylococci was the predominant isolate (12/21; 57.1%). The time from surgery to the onset of endophthalmitis was 7 days (interquartile range: 3–16) in patients with good best-corrected visual acuity (BCVA) (≥20/70) and 3 days (interquartile range: 1–8) in those with poor BCVA (<20/70). Multivariate linear regression analysis revealed that initial BCVA (logMAR) (p < 0.001), time from onset to initial intravitreal antibiotics (IVAs) (p < 0.001), and positive culture of highly virulent pathogens (p = 0.018) displayed significantly positive associations with the final BCVA (logMAR). Adjunctive use of intravitreal corticosteroids and systemic antibiotics were unrelated to a favorable final BCVA. In conclusion, the severity of the visual condition at baseline, as well as delayed treatment, are risk factors for poor visual outcomes in APSE.

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Section: Discussionsupporting

confidence: 92%

Management and Prognosis of Acute Post-Cataract Surgery Endophthalmitis: A 10-Year Retrospective Analysis in Eastern China

Zhang,

Chen,

et al. 2023

Antibiotics

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“…Smears and microbial cultures from the extracts of anterior chamber or vitreous had long been regarded as standard procedures for pathogen identification in endophthalmitis in the past [ 40 , 41 ]. Yield rates of stains and cultures varied but are generally low [ 40 , 42 , 43 ]. Recently, polymerase chain reaction (PCR) came into view as a promising, rapid, and precise alternative [ 44 , 45 ].…”

Section: Key Question 2: What Is the Optimal Clinical Approach Of Pat...mentioning

confidence: 99%

Literature- and Experience-Based Consensus for Acute Post-operative Endophthalmitis and Endogenous Endophthalmitis in Taiwan

Lee,

Sheu,

Chen

et al. 2023

Ophthalmol Ther

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Clinical practices on acute post-operative and endogenous endophthalmitis (EnE) are highly variable among clinicians due to a lack of up-to-date, high-quality evidential support. An expert consensus is thus much needed. A panel consisting of ten retinal specialists in Taiwan was organized. They evaluated relevant literature and developed key questions regarding acute post-operative and EnE that are cardinal for practice but yet to have conclusive evidence. The panel then attempted to reach consensus on all the key questions accordingly. There were eight key questions proposed and their respective consensus statements were summarized as follows: Gram staining and culture are still the standard procedures for the diagnosis of endophthalmitis. Vitrectomy is recommended to be performed earlier than the timing proposed by the Endophthalmitis Vitrectomy Study (EVS). Routine intracameral antibiotic injection for post-cataract surgery endophthalmitis prophylaxis is not recommended because of potential compounding error hazards and a lack of support from high-quality studies. Routine fundus examination is recommended for all patients with pyogenic liver abscess. In EnE, vitrectomy is recommended if diffused and dense vitritis is present, or if the disease progresses. These consensus statements may work as handy guidance or reference for clinical practices of acute post-operative and EnE.

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Lactobacillus acidophilus Endophthalmitis Postcataract Operation: A Case Report with a Literature Review

Hui

Ren

Wang

et al. 2023

Ocular Immunology and Inflammation

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Positive culture results and longer duration between onset and microincision vitrectomy have adverse effects on post-cataract surgery endophthalmitis outcome

Cited by 5 publications

References 19 publications

Management and Prognosis of Acute Post-Cataract Surgery Endophthalmitis: A 10-Year Retrospective Analysis in Eastern China

Management and Prognosis of Acute Post-Cataract Surgery Endophthalmitis: A 10-Year Retrospective Analysis in Eastern China

Literature- and Experience-Based Consensus for Acute Post-operative Endophthalmitis and Endogenous Endophthalmitis in Taiwan

Lactobacillus acidophilus Endophthalmitis Postcataract Operation: A Case Report with a Literature Review

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