Positive correlation between the expression of hEag1 and HIF-1α in breast cancers: an observational study

Lai, Qingxuan; Wang, Ting; Guo, Qisen; Zhang, Yuxiang; Wang, Youxin; Li, Yuan; Ling, Rui; He, Yihua; Wang, Wei

doi:10.1136/bmjopen-2014-005049

Cited by 16 publications

(14 citation statements)

References 38 publications

(64 reference statements)

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“…The expression of HIF-1a has been correlated to K v 10.1 level in breast cancer tissues. 142 These data are in agreement with those obtained in cell lines, showing that K v 10.1 expression increases HIF-1a levels and thus VEGF secretion, inducing tumor vascularization. 73,97 Resistance to hypoxic condition could also be enhanced by the overexpression of the K 2P channel KCNK9 in human breast and small-cell lung tumors.…”

supporting

confidence: 90%

Potassium and Sodium Channels and the Warburg Effect: Biophysical Regulation of Cancer Metabolism

et al. 2019

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Ion channels are progressively emerging as a novel class of membrane proteins expressed in several types of human cancers and regulating the different aspects of cancer cell behavior. The metabolism of cancer cells, usually composed by a variable proportion of respiration, glycolysis, and glutaminolysis, leads to the excessive production of acidic metabolic products. The presence of these acidic metabolites inside the cells results in intracellular acidosis, and hinders survival and proliferation. For this reason, tumor cells activate mechanisms of pH control that produce a constitutive increase in intracellular pH (pH i) that is more acidic than the extracellular pH (pH e). This condition forms a perfect microenvironment for metastatic progression and may be permissive for some of the acquired characteristics of tumors. Recent analyses have revealed complex interconnections between oncogenic activation, ion channels, hypoxia signaling and metabolic pathways that are dysregulated in cancer. Here, we summarize the molecular mechanisms of the Warburg effect and hypoxia and their association. Moreover, we discuss the recent findings concerning the involvement of ion channels in various aspects of the Warburg effect and hypoxia, focusing on the role of Na + and K + channels in hypoxic and metabolic reprogramming in cancer.

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supporting

confidence: 90%

Potassium and Sodium Channels and the Warburg Effect: Biophysical Regulation of Cancer Metabolism

et al. 2019

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“…Kv10.1 expression is mostly restricted to the central nervous system under healthy conditions. However, noticeable Kv10.1 levels are detected in clinical tumors from several different origins, including neuroblastomas [56], glioblastomas and derived brain metastasis [21], breast cancer [57,58], colon and gastric cancers [59,60], or osteosarcomas [61,62]. This evidence supports Kv10.1 as a potential marker for several cancers, such as cervical and colon cancer.…”

Section: Kv Channels and Cancermentioning

confidence: 65%

Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation

Serrano-Novillo

Capera

Colomer-Molera

et al. 2019

Cancers

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Voltage-gated potassium channels (Kv) are the largest group of ion channels. Kv are involved in controlling the resting potential and action potential duration in the heart and brain. Additionally, these proteins participate in cell cycle progression as well as in several other important features in mammalian cell physiology, such as activation, differentiation, apoptosis, and cell volume control. Therefore, Kv remarkably participate in the cell function by balancing responses. The implication of Kv in physiological and pathophysiological cell growth is the subject of study, as Kv are proposed as therapeutic targets for tumor regression. Though it is widely accepted that Kv channels control proliferation by allowing cell cycle progression, their role is controversial. Kv expression is altered in many cancers, and their participation, as well as their use as tumor markers, is worthy of effort. There is an ever-growing list of Kv that remodel during tumorigenesis. This review focuses on the actual knowledge of Kv channel expression and their relationship with neoplastic proliferation. In this work, we provide an update of what is currently known about these proteins, thereby paving the way for a more precise understanding of the participation of Kv during cancer development.

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“…The authors have demonstrated that blocking hEag1 with astemizole or silencing induces the breast cancer depolarization and consequently reduces the calcium influx and the cell migration without any influence on the cell proliferation [97]. These data are clinically valuable as hEAG1 are overexpressed in invasive ductal carcinoma breast cancer or metastatic lymph nodes [97,132] and their co-expression with HIF-1α is correlated with tumor size, lymph node status, and tumor stage [132], and the possibility of pharmacologically blocking these channels might represent a promising therapy. Moreover, astemizole may be used to pharmacologically discriminate hEAG from the related hERG potassium channels in MCF-7 breast cancer cells [133].…”

Section: Heag1 Channels As Pharmacological Targets In Breast Cancermentioning

confidence: 99%

Alterations in Calcium Signaling Pathways in Breast Cancer

Dumitru¹,

Toader²,

Creţoiu³

et al. 2018

Calcium and Signal Transduction

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Breast cancer is the second most common cancer in women and the fifth cause contributing to death due to the cancer condition. It is essential to deeply understand the complex cellular mechanisms leading to this disease. There are multiple connections between calcium homeostasis alterations and breast cancer in the literature, but no consensus links the mechanism to the disease prognosis. Among the cells contributing to the breast cancer are the breast telocytes, which connect through gap junctions to other cells, including cancer cells and myoepithelial cells. Multiple proteins (i.e., voltage-gated calcium channels, transient receptor potential channels, STIM and Orai proteins, ether à go-go potassium channels, calcium-activated potassium channels, calcium-activated chloride channels, muscarinic acetylcholine receptors, etc.) coupled with calcium signaling pathways undergo functional and/or expression changes associated with breast cancer development and progression, and might represent promising pharmacological targets. Unraveling the mechanisms of altered calcium homeostasis in various breast cells due to the cancer condition might contribute to personalized therapeutic approaches.

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Positive correlation between the expression of hEag1 and HIF-1α in breast cancers: an observational study

Cited by 16 publications

References 38 publications

Potassium and Sodium Channels and the Warburg Effect: Biophysical Regulation of Cancer Metabolism

Potassium and Sodium Channels and the Warburg Effect: Biophysical Regulation of Cancer Metabolism

Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation

Alterations in Calcium Signaling Pathways in Breast Cancer

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