Positive correlation between interleukin-1 receptor antagonist gene 86bp VNTR polymorphism and colorectal cancer susceptibility: a case-control study

Association between the Interleukin-1 Receptor Antagonist (IL1RN) Variable Number of Tandem Repeats (VNTR) Polymorphism and Lymphoma

“…In that same study, IL1RN levels were higher in the serum from patients with lung and colorectal cancer, gynecological carcinoma, and HL (as compared to serum from control subjects), which implies a critical role for this protein in the formation and development of tumors 19 . In contrast, Ibrahimi et al showed that 1/2 and 2/4 genotypes of IL1RN are correlated with colorectal cancer (CRC) susceptibility, and that allele 2 of IL-1RN is associated with CRC risk 20 . Furthermore, no significant differences in IL-1RA gene polymorphism were reported between hepatocellular carcinoma patients and control subjects 21 .…”

“…A growing body of evidence strongly suggests that chronic inflammation may be a potential risk factor for a variety of cancers. Cytokines play important roles in inflammation and immune responses, and can influence cancer susceptibility as well 20 . IL-1 is a key inflammatory cytokine that has been shown to induce tumor growth, angiogenesis, invasiveness and metastasis in various cancers 24 .…”

Genome-wide characterization of human minisatellite VNTRs: population-specific alleles and gene expression differences

“…For example, VNTR polymorphisms may play a role in neurogenesis and account for "human-specific cognitive traits" (37). Furthermore, minisatellite VNTRs have been associated with a variety of diseases (43,44,45), including cancer (46,47,48,49,50), neurodegenerative disorders (51) such as Alzheimer's c 2020 The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.…”

“…For example, VNTR polymorphisms may play a role in neurogenesis and account for “human-specific cognitive traits” (37). Furthermore, minisatellite VNTRs have been associated with a variety of diseases (43, 44, 45), including cancer (46, 47, 48, 49, 50), neurodegenerative disorders (51) such as Alzheimer’s disease (39, 52, 53) and Huntington’s disease (36, 54), and other psychiatric conditions, such as PTSD (55), ADHD (56, 57), depression (58), and addiction (59).…”

“…Furthermore, minisatellite VNTRs have been associated with a variety of diseases (53, 54, 55), including neurodegenerative disorders such as Alzheimer’s disease (36, 56, 57) and Huntington’s disease (28, 58), and other psychiatric conditions, such as PTSD (59), ADHD (60, 61), depression (62), and addiction (63). VNTRs have been shown to be risk factors in various cancers (64,65,66,67,68,69,70,71,72,73,74) and have been linked to cancer prognosis and outcome (75,76,77,78,79,80). Commercial cancer diagnosis kits using minisatellite VNTRs have been introduced (81) and it has been proposed that VNTRs associated with cancers be used for targeted sequencing in personalized therapies (82, 83, 84).…”