Positive correlation between human exposure to organophosphate esters and gastrointestinal cancer in patients from Wuhan, China

Yang, Li; Fu, Yourong; Hu, Kaiqi; Zhang, Yuanlu; Chen, Jianqiu; Zhang, Shenghu; Zhang, Bin; Liu, Yanhua

doi:10.1016/j.ecoenv.2020.110548

Cited by 30 publications

(15 citation statements)

References 60 publications

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“…Unfortunately, arylamines and other chemicals emitted from the azo dye used in the textile industry do not easily dissipate but evaporate into the air or are absorbed through the skin [55]. Thus, any human contact with synthetic dyes can trigger allergic reactions, skin irritations, and rashes, or at worse cancer [56]. Persistently, textile manufacturers pollute Chinese water bodies by dumping of Azo dyes into rivers.…”

Section: Water Pollution Challenges Facing Chinamentioning

confidence: 99%

Progressing towards Environmental Health Targets in China: An Integrative Review of Achievements in Air and Water Pollution under the “Ecological Civilisation and the Beautiful China” Dream

Antwi

Zhou

et al. 2021

Sustainability

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Despite the positive effect of industrialisation on health and quality of life indicators across the globe, it is also responsible for the release of chemical toxins into the environment. Thus, the pursuit of economic development through industrialisation has equally nurtured numerous environmental disasters with accompanying catastrophic health effects. China is one of the countries with high carbon emissions, but new policy changes have resulted in massive gains in controlling environmental damage while enhancing the environment-related quality of life. This paper combines the six-step integrative review strategy with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) strategy to determine appropriate exclusion and inclusion criteria to explore the available stock of literature. We note that overall pollution in China fell by 10% between 2014 and 2019 whereas the average fine particulate matter (PM2.5) concentration of 93 micrograms per cubic meter reduced by 47% by 2019. Beijing exhibited the top 200 most polluted cities in 2019 after recording the lowest PM2.5 ever. All cities that implemented the 2012 Environmental Air Quality Standards reduced the average concentration of PM2.5 and sulfur dioxide by 42–68% by the end of 2018. Improvements in freshwater quality and a decline in water pollution levels were recorded despite increases in economic growth, urbanisation, energy use, trade openness, and agriculture, all of which are major stimulants of pollution. Deterring environmental tariff, tight ecological inspections, closing down of non-compliant producers, heavy investment in environmental control, and the ambitious five year-plan to revitalise renewable energy goals emanating from China’s ecological civilisation masterplan are responsible for these improvements in air and water pollution. China needs to work more aggressively to consolidate the gains already made in order to quicken the actualisation of the ecological civilisation and beautiful China dream.

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Section: Water Pollution Challenges Facing Chinamentioning

confidence: 99%

Progressing towards Environmental Health Targets in China: An Integrative Review of Achievements in Air and Water Pollution under the “Ecological Civilisation and the Beautiful China” Dream

Antwi

Zhou

et al. 2021

Sustainability

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“…It is thought that there could be a positive correlation between serum TPP level, and gastrointestinal cancer and colorectal cancer. [13]The study con rmed that TPP aggravates the malignancy and progression of prostate cancer cells by inducing cancer cell migration, proliferation as well as increasing the heterogeneity of the cells. However, there is little information available on the potential association between TPP exposure and liver cancer.…”

Section: Discussionmentioning

confidence: 90%

“…In addition, we used transcriptome sequencing and qRT-PCR to compare and verify the gene expression differences in the liver cancer cells. The results showed that exposure of hepatoma cells to 30 ~ 60nM TPP plasma concentration [13] enhanced the proliferation and invasion ability of the cells.…”

Section: Introductionmentioning

confidence: 96%

“…Triphenyl phosphate (TPP) can promote the proliferation and migration of prostate cancer cells and aggravate the progression of prostate cancer [12]. It has been reported that the concentration of OPFRs in blood samples of people with gastrointestinal cancers is nearly 100 times higher than that in normal people (0.3nM), suggesting that the OPFRs might also be risk factors for gastrointestinal cancers [13]. Liver is supposed to be the main accumulation and metabolism tissue for OPFRs [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Low Triphenyl phosphate concentrations fuel proliferation and migration of Hep3B, a hepatocellular carcinoma cell line

Zhou

Zhang

et al. 2022

Preprint

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Organophosphate flame retardants (OPFRs) have been widely used due to their unique properties. The OPFRs are mainly metabolized in the liver. However, whether the OPFRs in human plasma mediate progression of liver cancer remains unclear. Triphenyl phosphate (TPP) is one of the OPFRs that are most detected in environmental matrices. In this study, we performed CCK8, ATP, and EdU analyses to evaluate the effect of TPP (0.025–12.8µM concentration) on proliferation, invasion, and migration of Hep3B, a hepatocellular carcinoma cell line. Tumor-bearing mouses model were used for in vivo validation. The results showed that relative low concentrations (0.025 to 0.1µM) slightly increased cell proliferation and remarkably promoted cell invasion and migration of Hep3B. Animal experiments confirmed that TPP treatment significantly enhanced tumor growth in the xenograft HCC model. To explore the possible molecular mechanisms that might be mediating the actions of TPP on Hep3B, we profiled gene expression in groups treated with or without TPP (0.05 and 0.1µM) using transcriptional sequencing. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment and Protein-Protein Interaction (PPI) analyses demonstrated that pathways affected by differentially expressed genes (DEGs) were mainly in nuclear-transcribed mRNA catabolic processes, cytosolic ribosome and ATPase activity. 0.05 and 0.1µM TPP led to up-regulation of a series of genes including EREG, DNPH1, SAMD9, DUSP5, PFN1, CKB, MICAL2, SCUBE3, and CXCL8, but suppressed the expression of MCC. These genes have been shown to be associated with proliferation and movement of cells. Together, our findings suggest that relatively low concentrations of TPP could fuel the proliferation, invasion, and migration of hepatocellular carcinoma cells. Thus, TPP might be a risk factor in the progression of hepatocellular carcinoma in humans.

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“…The current stock of literature a rm that any human contact with synthetic dyes can trigger allergic reactions, skin irritations and rashes or at worse cancer (Li, Fu et al 2020). A key feature of water pollution in China is the persistent dumping of Azo dyes into rivers by unsuspecting enterprises which contributes to the negative environmental health conditions in China.…”

Section: Water Pollutionmentioning

confidence: 99%

Progressing Towards Environmental Health Targets in China: A Systematic Review of Achievements in Air and Water Pollution under the “Ecological Civilization and the Beautiful China” Dream

Antwi¹

2020

Preprint

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Despite the positive effect of industrialization on health and quality of life indicators across the globe, it is also responsible for the release of chemical toxins into the environment and has nurtured numerous environmental disasters with severe health effects. China alone produces more than a third of carbon emissions in the world and currently has the second highest number of pollution-related deaths, after India. There is no issue that underscores the challenges of environmental crisis in China than the gradual acceptance of the existence of the cancer villages. These are entire towns that have been completely written off as so polluted that simply living there is synonymous with high rate of cancer risk. For years, residents and advocacy groups in villages such as Wuli, Yanglingang, Yangqiao and additional 459 identified cancer villages have waged a desperate war to turn the attention of government to the high risk of stomach, liver, kidney and colon cancer in these areas located near heavy industrial complexes. China responded by promoting an ecological civilization and a beautiful China dream as its sustainability blueprint in 2012. Today, this blueprint has been engraved into the national ideology for socio-economic and political orientation. This review therefore revisits the progress made towards environmental health targets under China’s sustainable development strategy. The study systematic explores the extant works on air and water pollution since the “Ecological Civilization and the Beautiful China” Dream.

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Positive correlation between human exposure to organophosphate esters and gastrointestinal cancer in patients from Wuhan, China

Cited by 30 publications

References 60 publications

Progressing towards Environmental Health Targets in China: An Integrative Review of Achievements in Air and Water Pollution under the “Ecological Civilisation and the Beautiful China” Dream

Progressing towards Environmental Health Targets in China: An Integrative Review of Achievements in Air and Water Pollution under the “Ecological Civilisation and the Beautiful China” Dream

Low Triphenyl phosphate concentrations fuel proliferation and migration of Hep3B, a hepatocellular carcinoma cell line

Progressing Towards Environmental Health Targets in China: A Systematic Review of Achievements in Air and Water Pollution under the “Ecological Civilization and the Beautiful China” Dream

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