Positive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles

Cunningham, Charles H.; Arai, Takayasu; Yang, Phillip C.; McConnell, Michael V.; Pauly, John M.; Conolly, Steven M.

doi:10.1002/mrm.20477

Cited by 386 publications

(343 citation statements)

References 22 publications

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“…Magnetic NPs, with both nanoscale size and magnetism, offer exciting opportunities for a wide range of applications, including data storage [175], magnetic fluids [176,177], catalysis [178], magnetic resonance imaging [179,180], and biomedicine [181,182]. In last decades, various approaches have been developed to synthesize magnetic NPs, among them, the representatives are co-precipitation, thermal decomposition and/or reduction, micelle synthesis, hydrothermal synthesis, and laser pyrolysis techniques [183].…”

Section: Magnetic Materialsmentioning

confidence: 99%

A review of plasma–liquid interactions for nanomaterial synthesis

Chen¹,

Li²,

Li³

2015

J. Phys. D: Appl. Phys.

290

225

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Over the past decades, a new branch of plasma research, the nanomaterial (NM) synthesis by plasma-liquid interactions (PLIs), is rapidly rising, mainly due to the recently developed various plasma sources operated from low to atmospheric pressures. The PLIs provide novel plasma-liquid interfaces where many physical and chemical processes take place. By exploiting these physical and chemical processes, various NMs ranging from noble metal nanoparticles to graphene nanosheets can be easily synthesized. The currently rapid development and increasingly wide utilization of the PLI method naturally lead to an urgent requirement for presenting a general review. This paper reviews the current status of research on plasma-liquid 2 interactions for nanomaterial syntheses. Focus is on the comprehensive understanding of the synthesis process and perceptive opinions on the present issues and future challenges in this subject.

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Section: Magnetic Materialsmentioning

confidence: 99%

A review of plasma–liquid interactions for nanomaterial synthesis

Chen¹,

Li²,

Li³

2015

J. Phys. D: Appl. Phys.

290

225

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“…The location of the divalent cations (Ni 2+ ) in the crystal structure is almost homologous to the magnetic properties of the nickel ferrite. However, nickel ferrite shows super-paramagnetic nature and it has diverse applications such as gas-sensor, magnetic fluids, catalysts, magnetic storage systems, photomagnetic materials, site-specific drug delivery, magnetic resonance imaging and microwave devices [3][4][5][6][7] . Various methods such as hydrothermal method 8 , co-precipitation method 9 , gelassistant hydrothermal route 10 , thermolysis 11 , wet chemical co-precipitation technique 12 , self-propagating 13 , have been developed to prepare nanocrystallite nickel ferrite.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Nickel ferrite Nanoparticles via Co-precipitation Method

2018

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Nickel ferrite (NiFe 2 O 4 ) nanoparticles were synthesized using co-precipitation method. The X-ray diffraction (XRD) pattern was used to determine the structure of NiFe 2 O 4 nanoparticles. The presence of NiFe 2 O 4 nanoparticles was confirmed by the FT-IR spectrum. The details of the surface morphology of NiFe 2 O 4 nanoparticles were obtained by Scanning Electron Microscopic analysis. The particle size of the NiFe 2 O 4 nanoparticles could be determined by means of Transmission Electron Microscopy. This work aimed at the investigation of the dielectric properties such as the dielectric loss and the dielectric constant of NiFe 2 O 4 nanoparticles at varied frequencies and temperatures. In addition, the magnetic properties of the NiFe 2 O 4 nanoparticles were studied.

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“…In MRI, magnetic materials such as gadolinium chelates and magnetic nanoparticles are often used (21)(22)(23) to enhance image contrast. The magnetic nanoparticles are passivated by biocompatible coatings such as dextrin, citrate, polystyrene/divinylbenzene, and elemental gold.…”

mentioning

confidence: 99%

Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles

Bouchard

Anwar

Liu

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

170

127

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Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.dual-modality imaging ͉ ferromagnetic nanoparticle ͉ molecular imaging ͉ MRI contrast ͉ photoacoustic tomography W e have synthesized nanoparticles for dual-modality (1-7)MRI and photoacoustic tomography (PAT). The incorporation of MRI and PAT into a single probe offers the unique possibility of combining the complementary strategies of contrastbased volume imaging and edge detection. Our nanoconstruct consists of zero-valence ferromagnetic cobalt (Co) particles (8) with a gold (Au) coating for biocompatibility and a unique shape rendering increased optical absorption over a broad range of frequencies (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). This research theme follows the rapid developments in nanotechnology, diagnostic radiology, and targeted molecular imaging (20), whereby nanoparticulate contrast agents, with the desirable properties of high chemical specificity, biocompatibility, and a reasonable half-life, are administered within a specific region of interest. In nanoparticle-based imaging studies, higher particle concentrations lead to better signal-to-noise contrasts, but this also poses a tradeoff with the toxicity. Therefore, one of the most important parameters when developing particle-based contrast is the safest and lowest nanoparticle concentration that offers sufficient contrast sensitivity.In MRI, magnetic materials such as gadolinium chelates and magnetic nanoparticles are often used (21-23) to enhance image contrast. The magnetic nanoparticles are passivated by biocompatible coatings such as dextrin, citrate, polystyrene/divinylbenzene, and elemental gold. These coatings also detoxify the particles, resulting in enhanced lifetimes in vivo. Typical examples of magnetic nanoparticulate core-shell configurations include magnetitedextrin, magnetite-silica (24) and iron-gold (25).Laser-based PAT (9-19) is a hybrid imaging modality [see supporting information (SI) Fig. S1]. It uses a pulsed laser source to illuminate a biological sample. Light absorption by the tissue results in a transient temperature rise on the order of 10 mK. The rapid thermoelastic expansion excites ultrasonic waves that are measured by using broadband ultrasonic transducers conformally arranged around the sample. Finally, a modif...

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Positive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles

Cited by 386 publications

References 22 publications

A review of plasma–liquid interactions for nanomaterial synthesis

A review of plasma–liquid interactions for nanomaterial synthesis

Preparation and Characterization of Nickel ferrite Nanoparticles via Co-precipitation Method

Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles

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