Positive chronotropic and inotropic responses to guanosine in the isolated dog atrium

Chiba, Shigetoshi; Kobayashi, Miyoharu; Furukawa, Yoshiko

doi:10.1016/0014-2999(78)90110-3

Cited by 4 publications

(6 citation statements)

References 4 publications

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“…Procaine could increase the force by an adrenergic mechanism (Chiba, 1977), in agreement with the fact that it shifts the plateau to more positive values in ventricular fibers, as norepinephrine does. For this reason, procaine and benzocaine were administered first in the absence and then in the presence of norepinephrine.…”

Section: The Effects Of Local Anesthetics In the Presence Of Norepinesupporting

confidence: 74%

“…A positive inotropic effect of procaine has been reported for canine atrial myocardium (Chiba, 1977) and bullfrog ventricular myocardium (Hatae, 1979). Both Chiba (1977) and Hatae (1979) considered the possibility that the increase in force might have been due to an adrenergic mechanism but came to different conclusions.…”

Section: Discussionmentioning

confidence: 99%

“…Both Chiba (1977) and Hatae (1979) considered the possibility that the increase in force might have been due to an adrenergic mechanism but came to different conclusions. Chiba showed that, with a concentration of propranolol that practically abolished the twitch, both norepinephrine and procaine had little effect on force.…”

Section: Discussionmentioning

confidence: 99%

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Local anesthetics and the role of sodium in the force development by canine ventricular muscle and purkinje fibers.

Vassalle

Bhattacharyya²

1980

Circulation Research

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We studied the effects of the local anesthetics, procaine and benzocaine, on the action potential and force of canine ventricular muscle and Purkinje fibers. In ventricular muscle, procaine often shifted the plateau to a more positive value and increased the force of contraction, whereas benzocaine shortened the action potential and decreased contractile force. In Purkinje fibers, both local anesthetics reduced contractile force and decreased the duration of the action potential markedly. In ventricular muscle fibers norepinephrine potentiated the positive inotropic effect of procaine and changed the effects of benzocaine from a negative to a positive inotropic effect. The potentiating effect of procaine on contraction was eliminated by propranolol. In the presence of norepinephrine (and the absence of propranolol), in Purkinje fibers both anesthetics decreased force but less than in the absence of norepinephrine. In the presence of tetrodotoxin (TTX) and norepinephrine, procaine and benzocaine increased contractile force of muscle fibers. Under the same conditions in Purkinje fibers, procaine increased contractile force and benzocaine decreased it (but less than in the absence of TTX). Administration of veratridine increased contractile force in both ventricular muscle and Purkinje fibers: under these conditions, both local anesthetics decreased contractile force in both tissues. We conclude that: (1) the positive inotropic effects of procaine and benzocaine are mediated through an adrenergic mechanism; (2) the negative inotropic effect is at least in part mediated through a reduction of sodium influx; and (3) the negative inotropic effect is more pronounced in Purkinje fibers because of a larger steady state sodium influx during the plateau.

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Section: The Effects Of Local Anesthetics In the Presence Of Norepinesupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

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Local anesthetics and the role of sodium in the force development by canine ventricular muscle and purkinje fibers.

Vassalle

Bhattacharyya²

1980

Circulation Research

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“…However, the positive chronotropic effect was not dose-dependent because of the concomitant negative chronotropic response. In similar experiments, Chiba (4) suggested that the positive chronotropic response induced by procaine in the isolated canine atrial preparation might be due to a direct stimulation of beta-receptors. However, in the present study the positive responses to procaine and prilocaine disappeared after treatment with propranolol, or in reserpine pretreated dogs.…”

Section: Discussionmentioning

confidence: 90%

“…Although it is well known that lidocaine and other similar local anesthetic agents cause a degree of cardiovascular depression (1), procaine has been reported by several investigators (2)(3)(4) to have excitatory effects. Therefore, there appears to exist qualitative differences among local anesthetic agents in their actions on the cardiovascular system.…”

mentioning

confidence: 99%

Comparison of the chronotropic responses to local anesthetics (procaine, lidocaine, prilocaine, mepivacaine and bupivacaine) of the canine sinus node in situ.

Satoh¹

1981

Jpn.J.Pharmacol

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Abstract-Effectsof local anesthetics (procaine, lidocaine, prilocaine, mepivacaine and bupivacaine) on the sinus node of the nerve-intact dog heart were studied in situ by means of selective perfusion of the sinus node through the sinus node artery. The agents caused a dose-dependent decrease in heart rate and the order of their potency in decreasing the heart rate was as follows, bupivacaine>lidocaine=mepivacaine=prilocaine> procaine. The decrease in heart rate produced by these local anesthetics was not affected by prior administration of atropine. With procaine and prilocaine, the decrease in heart rate was followed by an increase which was inhibited by propranolol given into the sinus node artery or was sup pressed in reserpine-pretreated dogs. Tetrodotoxin also prevented the positive chronotropic effect of procaine. From these results the following conclusion can be drawn: the negative chronotropic effects of these agents are induced mainly by a direct inhibitory action on the sinus node, and partly by blockade of sympathetic tone, and the interaction with the post ganglionic adrenergic nerves plays an important role in the induction of the positive chronotropic responses to procaine and prilocaine.

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Direct chronotropic and inotropic responses to guanosine and five different guanine nucleotides in isolated perfused dog atria

Chiba

Furukawa

Kobayashi

1979

European Journal of Pharmacology

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Positive chronotropic and inotropic responses to guanosine in the isolated dog atrium

Cited by 4 publications

References 4 publications

Local anesthetics and the role of sodium in the force development by canine ventricular muscle and purkinje fibers.

Local anesthetics and the role of sodium in the force development by canine ventricular muscle and purkinje fibers.

Comparison of the chronotropic responses to local anesthetics (procaine, lidocaine, prilocaine, mepivacaine and bupivacaine) of the canine sinus node in situ.

Direct chronotropic and inotropic responses to guanosine and five different guanine nucleotides in isolated perfused dog atria

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