Positive Association of Sperm Dysfunction in the Pathogenesis of Recurrent Pregnancy Loss

Kavitha, P; Malini, Suttur S.

doi:10.7860/jcdr/2014/9109.5172

Cited by 12 publications

(4 citation statements)

References 26 publications

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“…Thus, spermatozoa are often considered to be a silent vessel whose sole function is to deliver the haploid paternal genome to the haploid oocyte. The relative perceived insignificance of spermatozoa when compared to the oocyte may, in part, explain the lack of interest to develop sperm tests and the scarcity of relevant clinically validated tests for male factor infertility (Kavitha & Malini 2014).…”

Section: The Paternal Contribution To Infertility Is Frequently Overlmentioning

confidence: 99%

Meiotic nondisjunction and sperm aneuploidy in humans

2018

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Infertility is relatively common affecting approximately 1-in-6 couples. Although the genetic basis of infertility is increasingly being uncovered, the contribution of male infertility often remains unexplained. The leading cause of pregnancy loss and cognitive impairment in humans is chromosome aneuploidy. Sperm aneuploidy is routinely evaluated by fluorescence in situ hybridization. The majority of studies have reported similar findings, namely: (1) all men produce aneuploid sperm; (2) certain chromosomes are more prone to undergo chromosome nondisjunction; (3) infertile men typically have significantly higher levels of sperm aneuploidy compared to controls and (4) the level of aneuploidy is often correlated with the severity of the infertility. Despite this, sperm aneuploidy screening is rarely evaluated in the infertility clinic. Within recent years, there appears to be renewed interest in the clinical relevance of sperm aneuploidy. We shall examine the gender differences in meiosis between the sexes and explore why less emphasis is placed on the paternal contribution to aneuploidy. Increased sperm aneuploidy is often perceived to be modest and not clinically relevant, compared to the female contribution. However, even small increases in sperm aneuploidy may impact fertility and IVF cycle outcomes. Evidence demonstrating the clinical relevance of sperm aneuploidy will be discussed, as well as some of the challenges precluding widespread clinical implementation. Technological developments that may lead to widespread clinical implementation will be discussed. Recommendations will be suggested for specific patient groups that may benefit from sperm aneuploidy screening and whether preimplantation genetic testing for aneuploidy should be discussed with these patients.

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Section: The Paternal Contribution To Infertility Is Frequently Overlmentioning

confidence: 99%

Meiotic nondisjunction and sperm aneuploidy in humans

2018

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“…Despite adequate investigation, 50% of the cases are considered as idiopathic (Practice Committee of the American Society for Reproductive Medicine, 2012). Several authors have described an association between male factor and RPL (Kavitha & Malini, 2014;Ramasamy et al, 2015;Zidi-Jrah et al, 2016); in contrast, other authors reported no association between RPL and semen parameters (Carlini et al, 2017;Eisenberg, Sapra, Kim, Chen, & Buck Louis, 2017). The lack of good quality data establishing a relationship between male infertility and RPL is a possible explanation for the decreased interest in this clinical scenario.…”

Section: Despite Its Advantages Macs Is Yet To Be Certified By the Fmentioning

confidence: 96%

A scientometric analysis of research publications on male infertility and assisted reproductive technology

et al. 2020

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Assisted reproductive technologies (ART) are considered as one of the primary mana gement options to address severe male factor infertility. The purpose of this study was to identify the research trends in the field of male infertility and ART over the past 20 years (2000-2019) by analysing scientometric data (the number of publications per year, authors, author affiliations, journals, countries, type of documents, subject area and number of citations) retrieved using the Scopus database. We used VOS viewer software to generate a network map on international collaborations as well as a heat map of the top scientists in this field. Our results revealed a total of 2,148 publications during this period with Cleveland Clinic Foundation contributing the most (n = 69). The current scientometric analysis showed that the research trend on ART has been stable over the past two decades. Further in-depth analysis revealed that density gradient centrifugation (46%) and intracytoplasmic sperm injection (59.2%) are the most reported techniques for sperm separation and ART, respectively. Additionally, azoospermia was the most studied clinical scenario (60.6%), with majority of articles reporting pregnancy rate (47.25%) as the primary reproductive outcome for ART. This study provides insight into the current focus of research in the area of male infertility and ART as well as the areas that require further research in future.

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“…Тест на гипоосмотическое набухание сперматозои-дов успешно используется у разных видов млекопи-тающих и птиц (свиньи, слоны, обезьяны, крысы, эму [30], буйволы, бараны, жеребцы, собаки [31], быки [32]), причем со схожими значениями осмо-лярности, что свидетельствует об универсальности и информативности HOS-теста при оценке функцио-нального состояния сперматозоидов [33,34] и про-гнозирования их жизнеспособности [35]. Клиниче-ские наблюдения показали высокую корреляцию результатов HOS-теста и ВРТ (искусственная инсе-минация) [36], а также корреляцию результатов HOS-теста и прогноза развития привычного невына-шивания беременности [37], что подтверждает зна-чимость этого исследования при оценке фертильно-сти сперматозоидов. Также HOS-тест показал высо-кую информативность при оценке фертильности сперматозоидов в экспериментальных условиях, мо-делирующих бактериальную контаминацию спермы [38] и различные токсические воздействия [39,40].…”

Section: таблица 4 влияние продуктов секреции клинических изо-лятов unclassified

Toxic effect of Trichomonas vaginalis secretory products on human sperm in vitro

Lutskii¹,

Lutskaya²,

Makhmudov³

2015

Probl. reprod.

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Positive Association of Sperm Dysfunction in the Pathogenesis of Recurrent Pregnancy Loss

Cited by 12 publications

References 26 publications

Meiotic nondisjunction and sperm aneuploidy in humans

Meiotic nondisjunction and sperm aneuploidy in humans

A scientometric analysis of research publications on male infertility and assisted reproductive technology

Toxic effect of Trichomonas vaginalis secretory products on human sperm in vitro

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