Positive association of free triiodothyronine with pancreatic β‐cell function in people with prediabetes

Oda, Tomoyasu; Taneichi, Haruhito; Takahashi, Kazuma; Togashi, Hirobumi; Hangai, Mari; Nakagawa, Riyuki; Ono, Mikiko; Matsui, Mizue; Sasai, Takayoshi; Nagasawa, Kan; Honma, Hirotoshi; Kajiwara, Takashi; Takebe, Noriko; Ishigaki, Yasushi; Satoh, Jo

doi:10.1111/dme.12589

Cited by 20 publications

(16 citation statements)

References 33 publications

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“…In addition, thyroid dysfunction decreases glucose transport in myocytes and increases insulin resistance in muscle and adipose tissue [18,19]. Moreover, recent studies have demonstrated that FT3 can regulate insulin secretion [20,21]. erefore, FT3 may play an important role in glucose metabolism and insulin secretion.…”

Section: Discussionmentioning

confidence: 99%

Association between Normal Thyroid Hormones and Diabetic Retinopathy in Patients with Type 2 Diabetes

Zou

Tian³

et al. 2020

BioMed Research International

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The relationship between normal thyroid function and type 2 diabetes mellitus (T2DM) has been a particular focus for concern. The present study determined the relationship between thyroid hormone levels and the prevalence of diabetic retinopathy (DR) in T2DM patients. A cross-sectional study (n = 633) was performed in Xi’an, Shaanxi Province, China. Subjects were evaluated for anthropometric measurements, thyroid function, and diabetic retinopathy. Logistic regression models were used to assess the relationships between thyroid hormones and DR. Of 633 patients, 243 (38.4%) patients suffered from DR. The prevalence of DR showed a significantly decreasing trend across the quartiles based on free triiodothyronine (FT3) (FT3 quartile 1 group [FT3-Q1] <4.35 pmol/L, FT3 quartile 2 group [FT3-Q2] 4.35–4.70 pmol/L, FT3 quartile 3 group [FT3-Q3] 4.70–5.08 pmol/L, and FT3 quartile 4 group [FT3-Q4] ≥5.08 pmol/L) (56.7%, 42.5%, 33.1%, 23.8%, P<0.001). In comparison with all participants categorized in FT3-Q1, the multivariable adjusted odds ratios (95% confidence interval) of DR in FT3-Q2, FT3-Q3, and FT3-Q4 were 0.587 (0.340–1.012), 0.458 (0.258–0.813), and 0.368 (0.201–0.673), (P=0.055, P=0.008, P=0.001), respectively. FT3 levels within the normal range are negatively associated with DR in euthyroid patients with type 2 diabetes. Further studies should be aimed at clarifying the relationship between thyroid hormones and T2DM.

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Section: Discussionmentioning

confidence: 99%

Association between Normal Thyroid Hormones and Diabetic Retinopathy in Patients with Type 2 Diabetes

Zou

Tian³

et al. 2020

BioMed Research International

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“…However, regarding human studies, so far there have been few reports connecting T3 levels to pancreatic β cell function in prediabetic and diabetic patients. A multiple linear regression epidemiologic study [ 99 ] showed that free T3 is an independent variable with a positive correlation with all indexes of β cell function in the prediabetes and euthyroid group. In another study [ 100 ], a total of 266 patients with type 2 diabetes and normal thyroid function were recruited in order to study the associations between serum T3, FT3, and acute insulin response (AIR) in type 2 diabetes.…”

Section: Thyroid Hormone Treatment Ameliorates Pancreas Dysfunctiomentioning

confidence: 99%

The Roles of Thyroid and Thyroid Hormone in Pancreas: Physiology and Pathology

Chen

Xie

Shen

et al. 2018

International Journal of Endocrinology

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It is widely accepted that thyroid hormones (THs), secreted from the thyroid, play important roles in energy metabolism. It is also known that THs also alter the functioning of other endocrine glands; however, their effects on pancreatic function have not yet been reviewed. One of the main functions of the pancreas is insulin secretion, which is altered in diabetes. Diabetes, therefore, could be related to thyroid dysfunction. Earlier research on this subject focused on TH regulation of pancreas function (such as insulin secretion) or on insulin function through TH-mediated increase of energy metabolism. Afterwards, epidemiological investigations and animal test research found a link between autoimmune diseases, thyroid dysfunction, and pancreas pathology; however, the underlying mechanisms remain unknown. Furthermore, recent studies have shown that THs also play important roles in pancreas development and on islet pathology, both in diabetes and in pancreatic cancer. Therefore, an overview of the effects of thyroid and THs on pancreas physiology and pathology is presented. The topics contained in this review include a summary of the relationship between autoimmune thyroid dysfunction and autoimmune pancreas lesions and the effects of THs on pancreas development and pancreas pathology (diabetes and pancreatic cancer).

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“…Treatment of hypothyroidism has been revealed to restore insulin sensitivity and the secretion of glucoregulatory hormones [6,48]. The hyperthyroidism is associated with insulin resistance but this high and high-normal thyroid functions are protective to progression of diabetes as the hyperthyroidism causes increased insulin secretion [41,[49][50][51]. In vitro studies suggest that T3 and Thyroid Receptor alfa (TRα) promote proliferation of pancreatic islet cell.…”

Section: *Correspondencementioning

confidence: 99%

“…In vitro studies suggest that T3 and Thyroid Receptor alfa (TRα) promote proliferation of pancreatic islet cell. T3 also stimulates the islet transcription factor Mafa, which contributes to the transition of islets to glucose-responsive insulinsecreting cells, which further improves the insulin secretion in presence of higher free T3 in prediabetics [50][51]. Studies suggest that during hyperthyroidism the release of insulin precursors increases but they are inactive form and due to that insulin degradation rate increases and the half-life of insulin is reduced [52][53].…”

Section: *Correspondencementioning

confidence: 99%

Association of Diabetes Mellitus and Thyroid Disorders: A Metabolic Prospective

Mishra¹,

Relatado-Sotto²,

Panta³

et al. 2017

APJHS

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The prevalence of diabetes has nearly doubled since 1980, mounting from 4.7% to 8.5% in overall adult population. Thyroid disorder is another common endocrine disorder with prevalence of hypothyroidism as much as 4.6% and hyperthyroidism as much as 1.3% in population according to the National Health and Nutrition Examination Survey. These two most common endocrinopathies often co-exist and mutually influence each other. They have complex links of abnormal biochemical pathways, unregulated genetic expression of many genes and hormonal malfunctions. Thyroid hormones affects the regulation of carbohydrate metabolism, lipid metabolism and pancreatic function, and on the other hand, diabetes affects thyroid function tests to variable extents. In this review article we emphasized the epidemiology of diabetes and thyroid disorders, classification of thyroidism, and finally the impact of thyroidism to the various aspects of glucose and lipid metabolism in diabetics.

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Positive association of free triiodothyronine with pancreatic β‐cell function in people with prediabetes

Abstract: Free triiodothyronine is associated with both basal and glucose-stimulated insulin secretion in people with prediabetes who are euthyroid; therefore, the regulation of insulin secretion by thyroid hormones is a potentially novel therapeutic target for the treatment of diabetes.

Cited by 20 publications

References 33 publications

Association between Normal Thyroid Hormones and Diabetic Retinopathy in Patients with Type 2 Diabetes

Association between Normal Thyroid Hormones and Diabetic Retinopathy in Patients with Type 2 Diabetes

The Roles of Thyroid and Thyroid Hormone in Pancreas: Physiology and Pathology

Association of Diabetes Mellitus and Thyroid Disorders: A Metabolic Prospective

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